Risk factors for postoperative acute kidney injury after cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy: a meta-analysis and systematic review
Abstract Background Acute kidney injury after CRS + HIPEC is a serious postoperative complication, but only a few studies have reported its postoperative risk factors. In addition, there are large discrepancies in the results of available observational studies. Methods We searched The Cochrane Libra...
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BMC
2025-02-01
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| Series: | World Journal of Surgical Oncology |
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| Online Access: | https://doi.org/10.1186/s12957-025-03657-w |
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| author | Dengzhuo Chen Yongli Ma Jinghui Li Liang Wen Linfeng Liu Guosheng Zhang Hongkai Hu Chengzhi Huang Xueqing Yao |
| author_facet | Dengzhuo Chen Yongli Ma Jinghui Li Liang Wen Linfeng Liu Guosheng Zhang Hongkai Hu Chengzhi Huang Xueqing Yao |
| author_sort | Dengzhuo Chen |
| collection | DOAJ |
| description | Abstract Background Acute kidney injury after CRS + HIPEC is a serious postoperative complication, but only a few studies have reported its postoperative risk factors. In addition, there are large discrepancies in the results of available observational studies. Methods We searched The Cochrane Library, Embase, Web of Science,and PubMed to identify observational studies reporting risk factors for AKI after CRS + HIPEC. A meta-analysis was performed to investigate the effect of various preoperative and intraoperative risk factors on AKI after CRS + HIPEC. Results A total of 7 studies were included in this study, comprising 1550 patients who developed AKI after CRS + HIPEC. The results of meta-analysis showed that the significant preoperative risk factors were age, sex, BMI, eGFR, Hb, PCI, diabetes mellitus, and hypertension. IO cisplatin, IO SBP < 100 was identified as an intraoperative risk factor, whereas IO mitomycin emerged as a protective factor for postoperative AKI. In addition, the risk of postoperative AKI varied by primary tumor site, with Appendix being less prone to AKI, while mesothelioma and ovarian, two sites with a greatly elevated risk of postoperative AKI. Conclusions This meta-analysis identified a number of risk factors for postoperative AKI after CRS + HIPEC. By identifying these risk factors, it is more beneficial for clinicians to perform early preoperative interventions and select the most appropriate treatment strategy for their patients, thus minimizing the risk of postoperative AKI. Trial registration PROSPERO CRD42024585269. |
| format | Article |
| id | doaj-art-273486e63f334724897b265aea12e5f4 |
| institution | Kabale University |
| issn | 1477-7819 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMC |
| record_format | Article |
| series | World Journal of Surgical Oncology |
| spelling | doaj-art-273486e63f334724897b265aea12e5f42025-02-09T12:39:52ZengBMCWorld Journal of Surgical Oncology1477-78192025-02-0123112110.1186/s12957-025-03657-wRisk factors for postoperative acute kidney injury after cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy: a meta-analysis and systematic reviewDengzhuo Chen0Yongli Ma1Jinghui Li2Liang Wen3Linfeng Liu4Guosheng Zhang5Hongkai Hu6Chengzhi Huang7Xueqing Yao8Gannan Medical UniversityGanzhou Hospital of Guangdong Provincial People’s Hospital, Ganzhou Municipal HospitalGannan Medical UniversityGannan Medical UniversityGannan Medical UniversityGanzhou Hospital of Guangdong Provincial People’s Hospital, Ganzhou Municipal HospitalGanzhou Hospital of Guangdong Provincial People’s Hospital, Ganzhou Municipal HospitalDepartment of Gastrointestinal Surgery, Department of General Surgery, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical UniversityGannan Medical UniversityAbstract Background Acute kidney injury after CRS + HIPEC is a serious postoperative complication, but only a few studies have reported its postoperative risk factors. In addition, there are large discrepancies in the results of available observational studies. Methods We searched The Cochrane Library, Embase, Web of Science,and PubMed to identify observational studies reporting risk factors for AKI after CRS + HIPEC. A meta-analysis was performed to investigate the effect of various preoperative and intraoperative risk factors on AKI after CRS + HIPEC. Results A total of 7 studies were included in this study, comprising 1550 patients who developed AKI after CRS + HIPEC. The results of meta-analysis showed that the significant preoperative risk factors were age, sex, BMI, eGFR, Hb, PCI, diabetes mellitus, and hypertension. IO cisplatin, IO SBP < 100 was identified as an intraoperative risk factor, whereas IO mitomycin emerged as a protective factor for postoperative AKI. In addition, the risk of postoperative AKI varied by primary tumor site, with Appendix being less prone to AKI, while mesothelioma and ovarian, two sites with a greatly elevated risk of postoperative AKI. Conclusions This meta-analysis identified a number of risk factors for postoperative AKI after CRS + HIPEC. By identifying these risk factors, it is more beneficial for clinicians to perform early preoperative interventions and select the most appropriate treatment strategy for their patients, thus minimizing the risk of postoperative AKI. Trial registration PROSPERO CRD42024585269.https://doi.org/10.1186/s12957-025-03657-wCRSHIPECAKIRisk factors |
| spellingShingle | Dengzhuo Chen Yongli Ma Jinghui Li Liang Wen Linfeng Liu Guosheng Zhang Hongkai Hu Chengzhi Huang Xueqing Yao Risk factors for postoperative acute kidney injury after cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy: a meta-analysis and systematic review World Journal of Surgical Oncology CRS HIPEC AKI Risk factors |
| title | Risk factors for postoperative acute kidney injury after cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy: a meta-analysis and systematic review |
| title_full | Risk factors for postoperative acute kidney injury after cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy: a meta-analysis and systematic review |
| title_fullStr | Risk factors for postoperative acute kidney injury after cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy: a meta-analysis and systematic review |
| title_full_unstemmed | Risk factors for postoperative acute kidney injury after cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy: a meta-analysis and systematic review |
| title_short | Risk factors for postoperative acute kidney injury after cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy: a meta-analysis and systematic review |
| title_sort | risk factors for postoperative acute kidney injury after cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy a meta analysis and systematic review |
| topic | CRS HIPEC AKI Risk factors |
| url | https://doi.org/10.1186/s12957-025-03657-w |
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