Matrix metalloproteinase-3 is a potent prognostic factor associated with cell proliferation and migration in prostate cancer
Prostate cancer is a common malignancy in men around the world, and it is crucial to explore novel biomarkers to improve its treatment. Prostate cancer cells typically invade the surrounding stroma, and remodeling of the extracellular matrix (ECM) is a crucial step in the progress of prostate cancer...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-03-01
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| Series: | Experimental and Molecular Pathology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0014480025000036 |
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| author | Ai Sato Kiyoshi Takagi Mio Yamaguchi-Tanaka Jotaro Okushima Yuto Yamazaki Akihiro Ito Takashi Suzuki |
| author_facet | Ai Sato Kiyoshi Takagi Mio Yamaguchi-Tanaka Jotaro Okushima Yuto Yamazaki Akihiro Ito Takashi Suzuki |
| author_sort | Ai Sato |
| collection | DOAJ |
| description | Prostate cancer is a common malignancy in men around the world, and it is crucial to explore novel biomarkers to improve its treatment. Prostate cancer cells typically invade the surrounding stroma, and remodeling of the extracellular matrix (ECM) is a crucial step in the progress of prostate cancer. Matrix metalloproteinase-3 (MMP3) is an enzyme that degrades several ECM components and is implicated in human malignancies. However, the clinical and biological significance of MMP3 has not been well elucidated.We therefore immunolocalized MMP3 in prostate cancer tissues (n = 117) and demonstrated that MMP3 immunoreactivity was correlated with aggressive phenotype of prostate cancer, including higher proliferation/invasion ability, and shorter disease-free survival. In addition, subsequent in vitro analysis revealed that overexpression of MMP3 significantly increased the proliferative and migratory abilities of PC-3 and DU-145 prostate cancer cell lines, depending on conditioned media from WMPY-1 prostate stromal cells.It was concluded that MMP3 might contribute to prostate cancer progression by modifying the ECM surrounding prostate cancer cells and could serve as a potent prognostic factor in prostate cancer. |
| format | Article |
| id | doaj-art-2848bfe9b226437eb7268fb0123a6976 |
| institution | Kabale University |
| issn | 1096-0945 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Experimental and Molecular Pathology |
| spelling | doaj-art-2848bfe9b226437eb7268fb0123a69762025-02-11T04:33:28ZengElsevierExperimental and Molecular Pathology1096-09452025-03-01141104954Matrix metalloproteinase-3 is a potent prognostic factor associated with cell proliferation and migration in prostate cancerAi Sato0Kiyoshi Takagi1Mio Yamaguchi-Tanaka2Jotaro Okushima3Yuto Yamazaki4Akihiro Ito5Takashi Suzuki6Departments of Pathology and Histotechnology, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8575, JapanDepartments of Pathology and Histotechnology, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8575, Japan; Corresponding author.Departments of Pathology and Histotechnology, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8575, Japan; Departments of Personalized Medicine Center, 1-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8574, JapanDepartments of Pathology and Histotechnology, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8575, JapanDepartment of Pathology, Tohoku University Hospital, 1-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8574, JapanDepartments of Urology, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8575, JapanDepartments of Pathology and Histotechnology, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8575, Japan; Department of Pathology, Tohoku University Hospital, 1-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8574, Japan; Departments of Anatomic Pathology Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8575, JapanProstate cancer is a common malignancy in men around the world, and it is crucial to explore novel biomarkers to improve its treatment. Prostate cancer cells typically invade the surrounding stroma, and remodeling of the extracellular matrix (ECM) is a crucial step in the progress of prostate cancer. Matrix metalloproteinase-3 (MMP3) is an enzyme that degrades several ECM components and is implicated in human malignancies. However, the clinical and biological significance of MMP3 has not been well elucidated.We therefore immunolocalized MMP3 in prostate cancer tissues (n = 117) and demonstrated that MMP3 immunoreactivity was correlated with aggressive phenotype of prostate cancer, including higher proliferation/invasion ability, and shorter disease-free survival. In addition, subsequent in vitro analysis revealed that overexpression of MMP3 significantly increased the proliferative and migratory abilities of PC-3 and DU-145 prostate cancer cell lines, depending on conditioned media from WMPY-1 prostate stromal cells.It was concluded that MMP3 might contribute to prostate cancer progression by modifying the ECM surrounding prostate cancer cells and could serve as a potent prognostic factor in prostate cancer.http://www.sciencedirect.com/science/article/pii/S0014480025000036Matrix metalloproteinase-3Prostate cancerExtracellular matrixPrognosisImmunohistochemistry |
| spellingShingle | Ai Sato Kiyoshi Takagi Mio Yamaguchi-Tanaka Jotaro Okushima Yuto Yamazaki Akihiro Ito Takashi Suzuki Matrix metalloproteinase-3 is a potent prognostic factor associated with cell proliferation and migration in prostate cancer Experimental and Molecular Pathology Matrix metalloproteinase-3 Prostate cancer Extracellular matrix Prognosis Immunohistochemistry |
| title | Matrix metalloproteinase-3 is a potent prognostic factor associated with cell proliferation and migration in prostate cancer |
| title_full | Matrix metalloproteinase-3 is a potent prognostic factor associated with cell proliferation and migration in prostate cancer |
| title_fullStr | Matrix metalloproteinase-3 is a potent prognostic factor associated with cell proliferation and migration in prostate cancer |
| title_full_unstemmed | Matrix metalloproteinase-3 is a potent prognostic factor associated with cell proliferation and migration in prostate cancer |
| title_short | Matrix metalloproteinase-3 is a potent prognostic factor associated with cell proliferation and migration in prostate cancer |
| title_sort | matrix metalloproteinase 3 is a potent prognostic factor associated with cell proliferation and migration in prostate cancer |
| topic | Matrix metalloproteinase-3 Prostate cancer Extracellular matrix Prognosis Immunohistochemistry |
| url | http://www.sciencedirect.com/science/article/pii/S0014480025000036 |
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