Use of a specialized peptide-based enteral formula containing medium-chain triglycerides for enteral tube feeding in children with cerebral palsy and previous tube feeding intolerance on standard enteral formula: a prospective observational TolerUP study

Use of a specialized peptide-based enteral formula containing medium-chain triglycerides for enteral tube feeding in children with cerebral palsy and previous tube feeding intolerance on standard enteral formula: a prospective observational TolerUP study

ObjectiveUse of peptide-based formulas supplemented with medium chain triglycerides (MCTs) is considered a beneficial strategy to decrease the tube-feeding associated gastrointestinal tolerance. In children with cerebral palsy (CP), overall effects of enteral tube feeding as well as the utility of p...

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Main Authors: Aydan Kansu, Gunsel Kutluk, Gonul Caltepe, Cigdem Arikan, Nafiye Urganci, Gokhan Tumgor, Aysel Yuce, Ceyda Tuna Kirsaclioglu, Arzu Meltem Demir, Fatma Demirbas, Merve Usta, Sibel Yavuz, Duygu Demirtas Guner, Ersin Gumus, Buket Dalgic, Yasar Dogan, Nelgin Gerenli, Halil Kocamaz, Fulya Gulerman, Elif Sag, Aysugul Alptekin Sarioglu, Neslihan Eksi Bozbulut, Demet Teker Duztas, Hatice Altug Demirol, Coskun Celtik, Olcay Gungor, Kaan Demiroren, Aysen Uncuoglu Aydogan, Ozlem Bekem, Zeynep Arslan, Murat Cakir, Arzu Ekici, Nihal Uyar Aksu, Cigdem Ecevit, Simge Erdogan
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-02-01
Series:Frontiers in Pediatrics
Subjects:
cerebral palsy
peptide-based formula
gastrointestinal intolerance
anthropometrics
parental satisfaction
Online Access:https://www.frontiersin.org/articles/10.3389/fped.2025.1448507/full
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Summary:ObjectiveUse of peptide-based formulas supplemented with medium chain triglycerides (MCTs) is considered a beneficial strategy to decrease the tube-feeding associated gastrointestinal tolerance. In children with cerebral palsy (CP), overall effects of enteral tube feeding as well as the utility of peptide-based specialized enteral formulas in those with gastrointestinal intolerance have not been extensively studied. This study aimed to evaluate the utility of enteral tube feeding via specialized peptide-based formula containing MCTs in children with CP in terms of gastrointestinal intolerance, anthropometrics, defecation characteristics and parental satisfaction with enteral formula.MethodsChildren with CP who received enteral tube feeding via specialized peptide-based formula containing MCTs were included in this prospective observational study. Anthropometrics (z scores for weight for age [WFA], weight for height [WFH], triceps skinfold thickness [TSFT] and mid-upper arm circumference [MUAC]), gastrointestinal intolerance symptoms, defecation frequency and stool patterns and formula satisfaction were recorded at baseline and during 6-month follow up.ResultsA total of 96 children with CP (mean ± SD age: 5.6 ± 3.2 years, 56.3% were boys) were included. Significant improvements were noted in MUAC, TSFT and WFH z scores at the 6th month visit. The rate of “severe symptoms” and the likelihood of Type-1/Type-2 (constipation) stool pattern were significantly decreased. Majority of parents were satisfied with the study formula.ConclusionOur findings revealed favorable efficacy and safety of using a specialized peptide-based formula containing MCT in provision of enteral tube feeding among children with CP in terms of improved anthropometrics, amelioration of gastrointestinal intolerance symptoms and normalization of bowel movements along with a high parental satisfaction.
ISSN:2296-2360

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