Prothrombin complex concentrate for reversal of oral anticoagulants in patients with oral anticoagulation-related critical bleeding: a systematic review of randomised clinical trials

Prothrombin complex concentrate for reversal of oral anticoagulants in patients with oral anticoagulation-related critical bleeding: a systematic review of randomised clinical trials

Abstract Background Swift reversal of oral anticoagulation is deemed essential for the outcome of patients with anticoagulation-related critical bleeding. The aim of this systematic review was to evaluate the benefits and harms of prothrombin complex concentrate (PCC) in patients with oral anticoagu...

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Bibliographic Details
Main Authors: Christian Ovesen, Jan Purrucker, Josefine Grundtvig, Theis Bech Mikkelsen, Christian Gluud, Janus Christian Jakobsen, Hanne Christensen, Thorsten Steiner
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
Subjects:
Prothrombin complex concentrate
Anticoagulants
Vitamin K antagonist
Direct oral anticoagulants
Bleeding
Systematic review
Online Access:https://doi.org/10.1186/s13049-025-01334-1
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