Efficacy of a simple intravitreal perfluoropropane injection in treating unclosed idiopathic macular holes following vitrectomy
Abstract Background This study aimed to evaluate the efficacy of a simple intravitreal injection of perfluoropropane (C3F8) in treating unclosed idiopathic macular holes (IMHs) in patients who had previously undergone primary pars plana vitrectomy (PPV). Methods This study was a retrospective, obser...
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2025-02-01
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| Online Access: | https://doi.org/10.1186/s12886-024-03839-2 |
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| author | Zexia Dou Jindong Han Shaozhen Zhao |
| author_facet | Zexia Dou Jindong Han Shaozhen Zhao |
| author_sort | Zexia Dou |
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| description | Abstract Background This study aimed to evaluate the efficacy of a simple intravitreal injection of perfluoropropane (C3F8) in treating unclosed idiopathic macular holes (IMHs) in patients who had previously undergone primary pars plana vitrectomy (PPV). Methods This study was a retrospective, observational clinical study. It included patients diagnosed with unclosed IMHs following primary PPV combined with internal limiting membrane peeling and air tamponade. Optical coherence tomography (OCT) performed 1 week after PPV revealed unclosed IMHs with the presence of the ‘cuff’ sign and intraretinal cysts. The following day, these patients received a simple intravitreal C3F8 injection. Comprehensive evaluations, including best-corrected visual acuity (BCVA), indirect ophthalmoscopy, fundus photography, and OCT, were performed before PPV, 1 week after surgery, and at follow-up intervals of 1–3 months after the intravitreal gas injection. Results The minimum linear diameter (MLD) of the macular holes (MHs) 1 week before C3F8 injection was 335.1 ± 74.3 μm. Following C3F8 tamponade, the closure rate of the MHs was 100%. The mean BCVA before C3F8 tamponade was 0.68 ± 0.17 logMAR (20/100) after primary PPV, which improved to 0.48 ± 0.19 logMAR (20/63) after C3F8 tamponade, showing a statistically significant difference (P = 0.01). Conclusions For patients with unclosed MHs after primary PPV, the presence of the ‘cuff’ sign on OCT suggests that retreatment can be effectively achieved through a simple intravitreal gas injection. This approach is straightforward, practical, and effective. |
| format | Article |
| id | doaj-art-2881cc59b598413bb0e7572ac10c5df7 |
| institution | Kabale University |
| issn | 1471-2415 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMC |
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| series | BMC Ophthalmology |
| spelling | doaj-art-2881cc59b598413bb0e7572ac10c5df72025-02-09T12:26:17ZengBMCBMC Ophthalmology1471-24152025-02-012511510.1186/s12886-024-03839-2Efficacy of a simple intravitreal perfluoropropane injection in treating unclosed idiopathic macular holes following vitrectomyZexia Dou0Jindong Han1Shaozhen Zhao2Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye HospitalTianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye HospitalTianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye HospitalAbstract Background This study aimed to evaluate the efficacy of a simple intravitreal injection of perfluoropropane (C3F8) in treating unclosed idiopathic macular holes (IMHs) in patients who had previously undergone primary pars plana vitrectomy (PPV). Methods This study was a retrospective, observational clinical study. It included patients diagnosed with unclosed IMHs following primary PPV combined with internal limiting membrane peeling and air tamponade. Optical coherence tomography (OCT) performed 1 week after PPV revealed unclosed IMHs with the presence of the ‘cuff’ sign and intraretinal cysts. The following day, these patients received a simple intravitreal C3F8 injection. Comprehensive evaluations, including best-corrected visual acuity (BCVA), indirect ophthalmoscopy, fundus photography, and OCT, were performed before PPV, 1 week after surgery, and at follow-up intervals of 1–3 months after the intravitreal gas injection. Results The minimum linear diameter (MLD) of the macular holes (MHs) 1 week before C3F8 injection was 335.1 ± 74.3 μm. Following C3F8 tamponade, the closure rate of the MHs was 100%. The mean BCVA before C3F8 tamponade was 0.68 ± 0.17 logMAR (20/100) after primary PPV, which improved to 0.48 ± 0.19 logMAR (20/63) after C3F8 tamponade, showing a statistically significant difference (P = 0.01). Conclusions For patients with unclosed MHs after primary PPV, the presence of the ‘cuff’ sign on OCT suggests that retreatment can be effectively achieved through a simple intravitreal gas injection. This approach is straightforward, practical, and effective.https://doi.org/10.1186/s12886-024-03839-2Idiopathic macular holeIntravitreal gas injectionLong-acting gas perfluoropropaneC3F8Pars plana vitrectomyPrimary pars plana vitrectomy |
| spellingShingle | Zexia Dou Jindong Han Shaozhen Zhao Efficacy of a simple intravitreal perfluoropropane injection in treating unclosed idiopathic macular holes following vitrectomy BMC Ophthalmology Idiopathic macular hole Intravitreal gas injection Long-acting gas perfluoropropane C3F8 Pars plana vitrectomy Primary pars plana vitrectomy |
| title | Efficacy of a simple intravitreal perfluoropropane injection in treating unclosed idiopathic macular holes following vitrectomy |
| title_full | Efficacy of a simple intravitreal perfluoropropane injection in treating unclosed idiopathic macular holes following vitrectomy |
| title_fullStr | Efficacy of a simple intravitreal perfluoropropane injection in treating unclosed idiopathic macular holes following vitrectomy |
| title_full_unstemmed | Efficacy of a simple intravitreal perfluoropropane injection in treating unclosed idiopathic macular holes following vitrectomy |
| title_short | Efficacy of a simple intravitreal perfluoropropane injection in treating unclosed idiopathic macular holes following vitrectomy |
| title_sort | efficacy of a simple intravitreal perfluoropropane injection in treating unclosed idiopathic macular holes following vitrectomy |
| topic | Idiopathic macular hole Intravitreal gas injection Long-acting gas perfluoropropane C3F8 Pars plana vitrectomy Primary pars plana vitrectomy |
| url | https://doi.org/10.1186/s12886-024-03839-2 |
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