Trogocytosis-mediated immune evasion in the tumor microenvironment
Abstract Trogocytosis is a dynamic cellular process characterized by the exchange of the plasma membrane and associated cytosol during cell-to-cell interactions. Unlike phagocytosis, this transfer maintains the surface localization of transferred membrane molecules. For example, CD4 T cells engaging...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2025-01-01
|
| Series: | Experimental and Molecular Medicine |
| Online Access: | https://doi.org/10.1038/s12276-024-01364-2 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1825197578424156160 |
|---|---|
| author | Jeonghyun Kim Soyeon Park Jungseo Kim Yewon Kim Hong Min Yoon Bima Rexa Rayhan Jaekwang Jeong Alfred L. M. Bothwell Jae Hun Shin |
| author_facet | Jeonghyun Kim Soyeon Park Jungseo Kim Yewon Kim Hong Min Yoon Bima Rexa Rayhan Jaekwang Jeong Alfred L. M. Bothwell Jae Hun Shin |
| author_sort | Jeonghyun Kim |
| collection | DOAJ |
| description | Abstract Trogocytosis is a dynamic cellular process characterized by the exchange of the plasma membrane and associated cytosol during cell-to-cell interactions. Unlike phagocytosis, this transfer maintains the surface localization of transferred membrane molecules. For example, CD4 T cells engaging with antigen-presenting cells undergo trogocytosis, which facilitates the transfer of antigen-loaded major histocompatibility complex (MHC) class II molecules from antigen-presenting cells to CD4 T cells. This transfer results in the formation of antigen-loaded MHC class II molecule-dressed CD4 T cells. These “dressed” CD4 T cells subsequently participate in antigen presentation to other CD4 T cells. Additionally, trogocytosis enables the acquisition of immune-regulatory molecules, such as CTLA-4 and Tim3, in recipient cells, thereby modulating their anti-tumor immunity. Concurrently, donor cells undergo plasma membrane loss, and substantial loss can trigger trogocytosis-mediated cell death, termed trogoptosis. This review aims to explore the trogocytosis-mediated transfer of immune regulatory molecules and their implications within the tumor microenvironment to elucidate the underlying mechanisms of immune evasion in cancers. |
| format | Article |
| id | doaj-art-2895f5c0b82a46018aa59945fbe36183 |
| institution | Kabale University |
| issn | 2092-6413 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Experimental and Molecular Medicine |
| spelling | doaj-art-2895f5c0b82a46018aa59945fbe361832025-02-09T12:14:22ZengNature Publishing GroupExperimental and Molecular Medicine2092-64132025-01-0157111210.1038/s12276-024-01364-2Trogocytosis-mediated immune evasion in the tumor microenvironmentJeonghyun Kim0Soyeon Park1Jungseo Kim2Yewon Kim3Hong Min Yoon4Bima Rexa Rayhan5Jaekwang Jeong6Alfred L. M. Bothwell7Jae Hun Shin8Institute of Advanced Bio-Industry Convergence, Yonsei UniversityInstitute of Advanced Bio-Industry Convergence, Yonsei UniversityIntegrative Science and Engineering Division, Underwood International College, Yonsei UniversityIntegrative Science and Engineering Division, Underwood International College, Yonsei UniversityIntegrative Science and Engineering Division, Underwood International College, Yonsei UniversityIntegrative Science and Engineering Division, Underwood International College, Yonsei UniversityInternal Medicine, Yale University School of MedicineDepartment of Pathology, Microbiology and Immunology, University of Nebraska Medical CenterInstitute of Advanced Bio-Industry Convergence, Yonsei UniversityAbstract Trogocytosis is a dynamic cellular process characterized by the exchange of the plasma membrane and associated cytosol during cell-to-cell interactions. Unlike phagocytosis, this transfer maintains the surface localization of transferred membrane molecules. For example, CD4 T cells engaging with antigen-presenting cells undergo trogocytosis, which facilitates the transfer of antigen-loaded major histocompatibility complex (MHC) class II molecules from antigen-presenting cells to CD4 T cells. This transfer results in the formation of antigen-loaded MHC class II molecule-dressed CD4 T cells. These “dressed” CD4 T cells subsequently participate in antigen presentation to other CD4 T cells. Additionally, trogocytosis enables the acquisition of immune-regulatory molecules, such as CTLA-4 and Tim3, in recipient cells, thereby modulating their anti-tumor immunity. Concurrently, donor cells undergo plasma membrane loss, and substantial loss can trigger trogocytosis-mediated cell death, termed trogoptosis. This review aims to explore the trogocytosis-mediated transfer of immune regulatory molecules and their implications within the tumor microenvironment to elucidate the underlying mechanisms of immune evasion in cancers.https://doi.org/10.1038/s12276-024-01364-2 |
| spellingShingle | Jeonghyun Kim Soyeon Park Jungseo Kim Yewon Kim Hong Min Yoon Bima Rexa Rayhan Jaekwang Jeong Alfred L. M. Bothwell Jae Hun Shin Trogocytosis-mediated immune evasion in the tumor microenvironment Experimental and Molecular Medicine |
| title | Trogocytosis-mediated immune evasion in the tumor microenvironment |
| title_full | Trogocytosis-mediated immune evasion in the tumor microenvironment |
| title_fullStr | Trogocytosis-mediated immune evasion in the tumor microenvironment |
| title_full_unstemmed | Trogocytosis-mediated immune evasion in the tumor microenvironment |
| title_short | Trogocytosis-mediated immune evasion in the tumor microenvironment |
| title_sort | trogocytosis mediated immune evasion in the tumor microenvironment |
| url | https://doi.org/10.1038/s12276-024-01364-2 |
| work_keys_str_mv | AT jeonghyunkim trogocytosismediatedimmuneevasioninthetumormicroenvironment AT soyeonpark trogocytosismediatedimmuneevasioninthetumormicroenvironment AT jungseokim trogocytosismediatedimmuneevasioninthetumormicroenvironment AT yewonkim trogocytosismediatedimmuneevasioninthetumormicroenvironment AT hongminyoon trogocytosismediatedimmuneevasioninthetumormicroenvironment AT bimarexarayhan trogocytosismediatedimmuneevasioninthetumormicroenvironment AT jaekwangjeong trogocytosismediatedimmuneevasioninthetumormicroenvironment AT alfredlmbothwell trogocytosismediatedimmuneevasioninthetumormicroenvironment AT jaehunshin trogocytosismediatedimmuneevasioninthetumormicroenvironment |