Enhanced genome editing with a Streptococcus equinus Cas9

Enhanced genome editing with a Streptococcus equinus Cas9

Abstract A large number of SpCas9 orthologs has been computationally identified, but their genome editing potential remains largely unknown. In this study, a GFP-activation assay was used to screen a panel of 18 SpCas9 orthologs, ten of which demonstrated activity in human cells. Notably, these orth...

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Bibliographic Details
Main Authors: Jingtong Liu, Yao Wang, Jingjing Wei, Shengzhou Wang, Miaomiao Li, Zheyong Huang, Sufang Zhang, Huihui Liu, Jinhai Huang, Yongming Wang
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-025-07593-z
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