Phytochemical composition and antioxidant properties of Canarium odontophyllum (Sarawak Olive): A seasonal fruit from Borneo, East Malaysia
Background: Canarium species are reported rich of polyphenol, alkaloids, flavones, and saponins compounds. Canarium odontophyllum from Borneo's variety, on the other hand is remaining unclear especially on the antioxidant activity towards radicals. Purpose: To investigate phytochemical composit...
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Elsevier
2025-02-01
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| Series: | Phytomedicine Plus |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667031324001775 |
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| author | Gilbert Ringgit Bo Eng Cheong Muhammad Dawood Shah Shafiquzzaman Siddiquee |
| author_facet | Gilbert Ringgit Bo Eng Cheong Muhammad Dawood Shah Shafiquzzaman Siddiquee |
| author_sort | Gilbert Ringgit |
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| description | Background: Canarium species are reported rich of polyphenol, alkaloids, flavones, and saponins compounds. Canarium odontophyllum from Borneo's variety, on the other hand is remaining unclear especially on the antioxidant activity towards radicals. Purpose: To investigate phytochemical composition and antioxidant properties of C. odontophyllum. Methods: Antioxidant properties were evaluated using 2,2-diphenyl-1-picrylhydrazyl-hydrate (DPPH) assay, 2,2′-azino-bis(3-ethylbenzthiazoline-6-sulphonic acid) (ABTS) assay, and ferric-reducing antioxidant power (FRAP) assay with different polarity of extraction solvents (methanol, acetone and hexane). The phytochemical composition was determined by Liquid Chromatography Mass Spectrometry Quadrupole Time of Flight (LCMS-QTOF). Results: Acetone showed the highest scavenging activity in the DPPH (0.0307 mg/ml) and FRAP (3.926 mg/ml) assays, while hexane exhibited the highest activity in the ABTS assay (0.119 mg/ml). The LCMS-QTOF chromatogram identified 22 potential compounds. Among these, the major compounds oleamide (10.49 %) and emmotin A (7.23 %) have previously been reported to exhibit antioxidant activity. Other health-beneficial compounds were also found, such as palmitic amide (2.46 %), deoxymiroestrol (6.23 %), and N-Cyclohexanecarbonylpentadecylamine (48.92 %), which are important in preventing metal corrosion, regulating hormones, and distinguishing between N-palmitoylethanolamine-hydrolyzing acid amidase (NPAA) and fatty acid amide hydrolase (FAAH), respectively. Conclusion: The results indicate that C. odontophyllum shows a promising potential an alternative drug in pharmaceutical developments. |
| format | Article |
| id | doaj-art-28e538a3e013442d8f6f5c866e498509 |
| institution | Kabale University |
| issn | 2667-0313 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Phytomedicine Plus |
| spelling | doaj-art-28e538a3e013442d8f6f5c866e4985092025-02-10T04:35:11ZengElsevierPhytomedicine Plus2667-03132025-02-0151100703Phytochemical composition and antioxidant properties of Canarium odontophyllum (Sarawak Olive): A seasonal fruit from Borneo, East MalaysiaGilbert Ringgit0Bo Eng Cheong1Muhammad Dawood Shah2Shafiquzzaman Siddiquee3Biotechnology Research Institute, Universiti Malaysia Sabah, Jalan UMS, 88400 Kota Kinabalu, Sabah, MalaysiaBiotechnology Research Institute, Universiti Malaysia Sabah, Jalan UMS, 88400 Kota Kinabalu, Sabah, MalaysiaHigher Institute Centre of Excellence, Borneo Research Marine Institute, Universiti Malaysia Sabah, Jalan UMS, 88400 Kota Kinabalu, Sabah, MalaysiaBiotechnology Research Institute, Universiti Malaysia Sabah, Jalan UMS, 88400 Kota Kinabalu, Sabah, Malaysia; Corresponding author.Background: Canarium species are reported rich of polyphenol, alkaloids, flavones, and saponins compounds. Canarium odontophyllum from Borneo's variety, on the other hand is remaining unclear especially on the antioxidant activity towards radicals. Purpose: To investigate phytochemical composition and antioxidant properties of C. odontophyllum. Methods: Antioxidant properties were evaluated using 2,2-diphenyl-1-picrylhydrazyl-hydrate (DPPH) assay, 2,2′-azino-bis(3-ethylbenzthiazoline-6-sulphonic acid) (ABTS) assay, and ferric-reducing antioxidant power (FRAP) assay with different polarity of extraction solvents (methanol, acetone and hexane). The phytochemical composition was determined by Liquid Chromatography Mass Spectrometry Quadrupole Time of Flight (LCMS-QTOF). Results: Acetone showed the highest scavenging activity in the DPPH (0.0307 mg/ml) and FRAP (3.926 mg/ml) assays, while hexane exhibited the highest activity in the ABTS assay (0.119 mg/ml). The LCMS-QTOF chromatogram identified 22 potential compounds. Among these, the major compounds oleamide (10.49 %) and emmotin A (7.23 %) have previously been reported to exhibit antioxidant activity. Other health-beneficial compounds were also found, such as palmitic amide (2.46 %), deoxymiroestrol (6.23 %), and N-Cyclohexanecarbonylpentadecylamine (48.92 %), which are important in preventing metal corrosion, regulating hormones, and distinguishing between N-palmitoylethanolamine-hydrolyzing acid amidase (NPAA) and fatty acid amide hydrolase (FAAH), respectively. Conclusion: The results indicate that C. odontophyllum shows a promising potential an alternative drug in pharmaceutical developments.http://www.sciencedirect.com/science/article/pii/S2667031324001775Canarium odontophyllumBorneo's varietyLCMS Q-TOFDPPHABTSFRAP |
| spellingShingle | Gilbert Ringgit Bo Eng Cheong Muhammad Dawood Shah Shafiquzzaman Siddiquee Phytochemical composition and antioxidant properties of Canarium odontophyllum (Sarawak Olive): A seasonal fruit from Borneo, East Malaysia Phytomedicine Plus Canarium odontophyllum Borneo's variety LCMS Q-TOF DPPH ABTS FRAP |
| title | Phytochemical composition and antioxidant properties of Canarium odontophyllum (Sarawak Olive): A seasonal fruit from Borneo, East Malaysia |
| title_full | Phytochemical composition and antioxidant properties of Canarium odontophyllum (Sarawak Olive): A seasonal fruit from Borneo, East Malaysia |
| title_fullStr | Phytochemical composition and antioxidant properties of Canarium odontophyllum (Sarawak Olive): A seasonal fruit from Borneo, East Malaysia |
| title_full_unstemmed | Phytochemical composition and antioxidant properties of Canarium odontophyllum (Sarawak Olive): A seasonal fruit from Borneo, East Malaysia |
| title_short | Phytochemical composition and antioxidant properties of Canarium odontophyllum (Sarawak Olive): A seasonal fruit from Borneo, East Malaysia |
| title_sort | phytochemical composition and antioxidant properties of canarium odontophyllum sarawak olive a seasonal fruit from borneo east malaysia |
| topic | Canarium odontophyllum Borneo's variety LCMS Q-TOF DPPH ABTS FRAP |
| url | http://www.sciencedirect.com/science/article/pii/S2667031324001775 |
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