Refining α-synuclein seed amplification assays to distinguish Parkinson’s disease from multiple system atrophy

Refining α-synuclein seed amplification assays to distinguish Parkinson’s disease from multiple system atrophy

Abstract Background Parkinson’s disease (PD) and multiple system atrophy (MSA) are two distinct α-synucleinopathies traditionally differentiated through clinical symptoms. Early diagnosis of MSA is problematic, and seed amplification assays (SAAs), such as real-time quaking-induced conversion (RT-Qu...

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Bibliographic Details
Main Authors: James A. Wiseman, Clinton P. Turner, Richard L. M. Faull, Glenda M. Halliday, Birger Victor Dieriks
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Translational Neurodegeneration
Subjects:
α-Synuclein
Parkinson’s disease
Multiple system atrophy
Seed amplification assays
α-Synuclein strains
Conformational variability
Online Access:https://doi.org/10.1186/s40035-025-00469-6
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