Causal relationship between educational attainment and the occurrence of venous thromboembolism
Abstract Background The association between educational attainment (EA) and arterial thrombotic disease has been reported, but the causal relationship between EA and venous thromboembolism (VTE) is not clear. We aimed to assess the causal effect of EA on VTE using the two-sample mendelian randomizat...
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BMC
2025-02-01
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| Series: | BMC Medical Genomics |
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| Online Access: | https://doi.org/10.1186/s12920-025-02092-w |
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| author | Sitong Guo Sitao Tan Shiran Qin Dandan Xu Henghai Su Xiaoyu Chen |
| author_facet | Sitong Guo Sitao Tan Shiran Qin Dandan Xu Henghai Su Xiaoyu Chen |
| author_sort | Sitong Guo |
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| description | Abstract Background The association between educational attainment (EA) and arterial thrombotic disease has been reported, but the causal relationship between EA and venous thromboembolism (VTE) is not clear. We aimed to assess the causal effect of EA on VTE using the two-sample mendelian randomization (MR) method. Methods Data mining was conducted on the genome wide association studies (GWAS), with exposure factor EA and outcome factor VTE. Two-sample Mendelian Randomization (TSMR) analysis was conducted, with the results obtained from the random effects inverse variance weighted method (IVW). Use the MR-Egger method for pleiotropy analysis and leave one method for sensitivity analysis to verify the reliability of the data. Results Genetically predicted decreased EA was associated with a decreased risk of VTE in both the FinnGen consortium and UK Biobank (FinnGen-VTE: OR = 0.848; 95% CI 0.776—0.927; P = 2.84 × 10–4; UKB-VTE OR = 0.996; 95% CI 0.994—0.999; P = 0.008) under a multiplicative random-effects IVW model. Results were consistent in all sensitivity analyses and no horizontal pleiotropy was detected. Conclusions The MR technique instructed a potential inverse causative relationship between EA and occurrence of VTE. Therefore, patients with low EA should be more vigilant about the occurrence of VTE. |
| format | Article |
| id | doaj-art-2b0f78e163f44c6fa078e3ead4ad5c0d |
| institution | Kabale University |
| issn | 1755-8794 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMC |
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| series | BMC Medical Genomics |
| spelling | doaj-art-2b0f78e163f44c6fa078e3ead4ad5c0d2025-02-09T12:58:54ZengBMCBMC Medical Genomics1755-87942025-02-011811710.1186/s12920-025-02092-wCausal relationship between educational attainment and the occurrence of venous thromboembolismSitong Guo0Sitao Tan1Shiran Qin2Dandan Xu3Henghai Su4Xiaoyu Chen5Department of Pharmacy, Guangxi Academy of Medical Sciences and the People’s Hospital of Guangxi Zhuang Autonomous RegionDepartment of Pharmacy, Guangxi Academy of Medical Sciences and the People’s Hospital of Guangxi Zhuang Autonomous RegionDepartment of Pharmacy, Guangxi Academy of Medical Sciences and the People’s Hospital of Guangxi Zhuang Autonomous RegionDepartment of Pharmacy, Guangxi Academy of Medical Sciences and the People’s Hospital of Guangxi Zhuang Autonomous RegionDepartment of Pharmacy, Guangxi Academy of Medical Sciences and the People’s Hospital of Guangxi Zhuang Autonomous RegionDepartment of Pharmacy, Guangxi Academy of Medical Sciences and the People’s Hospital of Guangxi Zhuang Autonomous RegionAbstract Background The association between educational attainment (EA) and arterial thrombotic disease has been reported, but the causal relationship between EA and venous thromboembolism (VTE) is not clear. We aimed to assess the causal effect of EA on VTE using the two-sample mendelian randomization (MR) method. Methods Data mining was conducted on the genome wide association studies (GWAS), with exposure factor EA and outcome factor VTE. Two-sample Mendelian Randomization (TSMR) analysis was conducted, with the results obtained from the random effects inverse variance weighted method (IVW). Use the MR-Egger method for pleiotropy analysis and leave one method for sensitivity analysis to verify the reliability of the data. Results Genetically predicted decreased EA was associated with a decreased risk of VTE in both the FinnGen consortium and UK Biobank (FinnGen-VTE: OR = 0.848; 95% CI 0.776—0.927; P = 2.84 × 10–4; UKB-VTE OR = 0.996; 95% CI 0.994—0.999; P = 0.008) under a multiplicative random-effects IVW model. Results were consistent in all sensitivity analyses and no horizontal pleiotropy was detected. Conclusions The MR technique instructed a potential inverse causative relationship between EA and occurrence of VTE. Therefore, patients with low EA should be more vigilant about the occurrence of VTE.https://doi.org/10.1186/s12920-025-02092-wEducational attainmentVenous thromboembolismMendelian randomizationCausal associationRisk factor |
| spellingShingle | Sitong Guo Sitao Tan Shiran Qin Dandan Xu Henghai Su Xiaoyu Chen Causal relationship between educational attainment and the occurrence of venous thromboembolism BMC Medical Genomics Educational attainment Venous thromboembolism Mendelian randomization Causal association Risk factor |
| title | Causal relationship between educational attainment and the occurrence of venous thromboembolism |
| title_full | Causal relationship between educational attainment and the occurrence of venous thromboembolism |
| title_fullStr | Causal relationship between educational attainment and the occurrence of venous thromboembolism |
| title_full_unstemmed | Causal relationship between educational attainment and the occurrence of venous thromboembolism |
| title_short | Causal relationship between educational attainment and the occurrence of venous thromboembolism |
| title_sort | causal relationship between educational attainment and the occurrence of venous thromboembolism |
| topic | Educational attainment Venous thromboembolism Mendelian randomization Causal association Risk factor |
| url | https://doi.org/10.1186/s12920-025-02092-w |
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