Pancreatic organogenesis mapped through space and time
Abstract The spatial organization of cells within a tissue is dictated throughout dynamic developmental processes. We sought to understand whether cells geometrically coordinate with one another throughout development to achieve their organization. The pancreas is a complex cellular organ with a par...
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| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2025-01-01
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| Series: | Experimental and Molecular Medicine |
| Online Access: | https://doi.org/10.1038/s12276-024-01384-y |
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| _version_ | 1825197580118654976 |
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| author | Marissa A. Scavuzzo Wojciech J. Szlachcic Matthew C. Hill Natalia M. Ziojla Jessica Teaw Jeffrey C. Carlson Jonathan Tiessen Jolanta Chmielowiec James F. Martin Malgorzata Borowiak |
| author_facet | Marissa A. Scavuzzo Wojciech J. Szlachcic Matthew C. Hill Natalia M. Ziojla Jessica Teaw Jeffrey C. Carlson Jonathan Tiessen Jolanta Chmielowiec James F. Martin Malgorzata Borowiak |
| author_sort | Marissa A. Scavuzzo |
| collection | DOAJ |
| description | Abstract The spatial organization of cells within a tissue is dictated throughout dynamic developmental processes. We sought to understand whether cells geometrically coordinate with one another throughout development to achieve their organization. The pancreas is a complex cellular organ with a particular spatial organization. Signals from the mesenchyme, neurons, and endothelial cells instruct epithelial cell differentiation during pancreatic development. To understand the cellular diversity and spatial organization of the developing pancreatic niche, we mapped the spatial relationships between single cells over time. We found that four transcriptionally unique subtypes of mesenchyme in the developing pancreas spatially coordinate throughout development, with each subtype at fixed locations in space and time in relation to other cells, including beta cells, vasculature, and epithelial cells. Our work provides insight into the mechanisms of pancreatic development by showing that cells are organized in a space and time manner. |
| format | Article |
| id | doaj-art-2b164191956b487d8bb24f6c9139a932 |
| institution | Kabale University |
| issn | 2092-6413 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Experimental and Molecular Medicine |
| spelling | doaj-art-2b164191956b487d8bb24f6c9139a9322025-02-09T12:14:23ZengNature Publishing GroupExperimental and Molecular Medicine2092-64132025-01-0157120422010.1038/s12276-024-01384-yPancreatic organogenesis mapped through space and timeMarissa A. Scavuzzo0Wojciech J. Szlachcic1Matthew C. Hill2Natalia M. Ziojla3Jessica Teaw4Jeffrey C. Carlson5Jonathan Tiessen6Jolanta Chmielowiec7James F. Martin8Malgorzata Borowiak9Program in Developmental Biology, Baylor College of MedicineInstitute of Molecular Biology and Biotechnology, Adam Mickiewicz UniversityProgram in Developmental Biology, Baylor College of MedicineInstitute of Molecular Biology and Biotechnology, Adam Mickiewicz UniversityCenter for Cell and Gene Therapy, Baylor College of Medicine, Texas Children’s Hospital, and Houston Methodist HospitalProgram in Developmental Biology, Baylor College of MedicineProgram in Developmental Biology, Baylor College of MedicineCenter for Cell and Gene Therapy, Baylor College of Medicine, Texas Children’s Hospital, and Houston Methodist HospitalProgram in Developmental Biology, Baylor College of MedicineProgram in Developmental Biology, Baylor College of MedicineAbstract The spatial organization of cells within a tissue is dictated throughout dynamic developmental processes. We sought to understand whether cells geometrically coordinate with one another throughout development to achieve their organization. The pancreas is a complex cellular organ with a particular spatial organization. Signals from the mesenchyme, neurons, and endothelial cells instruct epithelial cell differentiation during pancreatic development. To understand the cellular diversity and spatial organization of the developing pancreatic niche, we mapped the spatial relationships between single cells over time. We found that four transcriptionally unique subtypes of mesenchyme in the developing pancreas spatially coordinate throughout development, with each subtype at fixed locations in space and time in relation to other cells, including beta cells, vasculature, and epithelial cells. Our work provides insight into the mechanisms of pancreatic development by showing that cells are organized in a space and time manner.https://doi.org/10.1038/s12276-024-01384-y |
| spellingShingle | Marissa A. Scavuzzo Wojciech J. Szlachcic Matthew C. Hill Natalia M. Ziojla Jessica Teaw Jeffrey C. Carlson Jonathan Tiessen Jolanta Chmielowiec James F. Martin Malgorzata Borowiak Pancreatic organogenesis mapped through space and time Experimental and Molecular Medicine |
| title | Pancreatic organogenesis mapped through space and time |
| title_full | Pancreatic organogenesis mapped through space and time |
| title_fullStr | Pancreatic organogenesis mapped through space and time |
| title_full_unstemmed | Pancreatic organogenesis mapped through space and time |
| title_short | Pancreatic organogenesis mapped through space and time |
| title_sort | pancreatic organogenesis mapped through space and time |
| url | https://doi.org/10.1038/s12276-024-01384-y |
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