Effect of Metadoxine on Chronic Primary Hepatopathies in Canines: Number of Cases
Objective. To evaluate the effect of Metadoxine on paraclinical, ultrasound, and histopathological findings in canines with primary hepatopathies through a number of cases. Materials and Methods. Seven dogs aged 2 to 14 years with mild to moderate clinical signs of primary hepatopathy, abnormal bil...
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Universidad de Cordoba
2023-09-01
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| Series: | Revista MVZ Cordoba |
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| Online Access: | https://revistamvz.unicordoba.edu.co/article/view/3103 |
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| author | Paula María Bermúdez-Duarte José Alfredo Rivera-Rojas |
| author_facet | Paula María Bermúdez-Duarte José Alfredo Rivera-Rojas |
| author_sort | Paula María Bermúdez-Duarte |
| collection | DOAJ |
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Objective. To evaluate the effect of Metadoxine on paraclinical, ultrasound, and histopathological findings in canines with primary hepatopathies through a number of cases. Materials and Methods. Seven dogs aged 2 to 14 years with mild to moderate clinical signs of primary hepatopathy, abnormal bile acids, increased ALT or ALP values three times above the upper range for 4 weeks, underwent ultrasound evaluation and ultrasound-guided Tru-Cut liver biopsy to confirm hepatopathy according to the histological classification of the WSAVA. Prior to the biopsy, they were required to have fibrinogen >100 mg/dL, platelets >100 cells x 103/µL, and prothrombin time <11.5 seconds. Once the histological diagnosis was confirmed, they received metadoxine at 17±11.35 mg/kg every 12 hours for 4 weeks. Clinical, paraclinical, ultrasound, and histopathological follow-up was conducted at the end of this period. Results. A decrease in the occurrence of vomiting and anorexia was observed (p=0.03), a non-significant increase in ALT and ALP (p=0.84; p=0.43), a reduction in bile acids (p=0.4), and no change in ultrasound score (p=0.42) or histopathological diagnosis (p>0.05). Conclusions. Despite significant limitations, this number of cases provides preliminary observation suggesting that metadoxine may improve the clinical condition of dogs with liver disease without altering paraclinical, ultrasound, or histological variables; additional research with a Randomized Clinical Trial design is needed to propose metadoxine indication protocols for canines with hepatopathies in clinical practice.
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| format | Article |
| id | doaj-art-2b1e88705a4245949436d8b98a0a1c56 |
| institution | Kabale University |
| issn | 0122-0268 1909-0544 |
| language | English |
| publishDate | 2023-09-01 |
| publisher | Universidad de Cordoba |
| record_format | Article |
| series | Revista MVZ Cordoba |
| spelling | doaj-art-2b1e88705a4245949436d8b98a0a1c562025-02-11T17:17:21ZengUniversidad de CordobaRevista MVZ Cordoba0122-02681909-05442023-09-0128310.21897/rmvz.3103Effect of Metadoxine on Chronic Primary Hepatopathies in Canines: Number of CasesPaula María Bermúdez-Duarte0https://orcid.org/0000-0003-2294-3539José Alfredo Rivera-Rojas1Universidad de la Salle, Colombia.Universidad de la Salle, Colombia. Objective. To evaluate the effect of Metadoxine on paraclinical, ultrasound, and histopathological findings in canines with primary hepatopathies through a number of cases. Materials and Methods. Seven dogs aged 2 to 14 years with mild to moderate clinical signs of primary hepatopathy, abnormal bile acids, increased ALT or ALP values three times above the upper range for 4 weeks, underwent ultrasound evaluation and ultrasound-guided Tru-Cut liver biopsy to confirm hepatopathy according to the histological classification of the WSAVA. Prior to the biopsy, they were required to have fibrinogen >100 mg/dL, platelets >100 cells x 103/µL, and prothrombin time <11.5 seconds. Once the histological diagnosis was confirmed, they received metadoxine at 17±11.35 mg/kg every 12 hours for 4 weeks. Clinical, paraclinical, ultrasound, and histopathological follow-up was conducted at the end of this period. Results. A decrease in the occurrence of vomiting and anorexia was observed (p=0.03), a non-significant increase in ALT and ALP (p=0.84; p=0.43), a reduction in bile acids (p=0.4), and no change in ultrasound score (p=0.42) or histopathological diagnosis (p>0.05). Conclusions. Despite significant limitations, this number of cases provides preliminary observation suggesting that metadoxine may improve the clinical condition of dogs with liver disease without altering paraclinical, ultrasound, or histological variables; additional research with a Randomized Clinical Trial design is needed to propose metadoxine indication protocols for canines with hepatopathies in clinical practice. https://revistamvz.unicordoba.edu.co/article/view/3103liver diseasesDogsimage-guided biopsyPyridoxinepyroglutamic acid |
| spellingShingle | Paula María Bermúdez-Duarte José Alfredo Rivera-Rojas Effect of Metadoxine on Chronic Primary Hepatopathies in Canines: Number of Cases Revista MVZ Cordoba liver diseases Dogs image-guided biopsy Pyridoxine pyroglutamic acid |
| title | Effect of Metadoxine on Chronic Primary Hepatopathies in Canines: Number of Cases |
| title_full | Effect of Metadoxine on Chronic Primary Hepatopathies in Canines: Number of Cases |
| title_fullStr | Effect of Metadoxine on Chronic Primary Hepatopathies in Canines: Number of Cases |
| title_full_unstemmed | Effect of Metadoxine on Chronic Primary Hepatopathies in Canines: Number of Cases |
| title_short | Effect of Metadoxine on Chronic Primary Hepatopathies in Canines: Number of Cases |
| title_sort | effect of metadoxine on chronic primary hepatopathies in canines number of cases |
| topic | liver diseases Dogs image-guided biopsy Pyridoxine pyroglutamic acid |
| url | https://revistamvz.unicordoba.edu.co/article/view/3103 |
| work_keys_str_mv | AT paulamariabermudezduarte effectofmetadoxineonchronicprimaryhepatopathiesincaninesnumberofcases AT josealfredoriverarojas effectofmetadoxineonchronicprimaryhepatopathiesincaninesnumberofcases |