Does the COVID-19 XBB Omicron subvariant signal the beginning of the end of the pandemic?
All pandemic viruses have eventually adapted to human hosts so that they become more transmissible and less virulent. The XBB Omicron subvariant is rapidly becoming the dominant strain of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) in Singapore from October 2022 and is one of severa...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer – Medknow Publications
2024-12-01
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| Series: | Singapore Medical Journal |
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| Online Access: | https://journals.lww.com/10.4103/singaporemedj.SMJ-2022-180 |
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| _version_ | 1823863746780463104 |
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| author | Jinghao Nicholas Ngiam Abdurrahmaan Al-Mubaarak Sebastian Maurer-Stroh Paul Anantharajah Tambyah |
| author_facet | Jinghao Nicholas Ngiam Abdurrahmaan Al-Mubaarak Sebastian Maurer-Stroh Paul Anantharajah Tambyah |
| author_sort | Jinghao Nicholas Ngiam |
| collection | DOAJ |
| description | All pandemic viruses have eventually adapted to human hosts so that they become more transmissible and less virulent. The XBB Omicron subvariant is rapidly becoming the dominant strain of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) in Singapore from October 2022 and is one of several variants circulating globally with the potential to dominate autumn/winter waves in different countries. The XBB Omicron subvariant has demonstrated increased transmissibility through an apparent propensity for immune evasion. This is to be expected in the natural evolution of a virus in a population highly vaccinated with a vaccine targeting the spike protein of the original Wuhan strain of the virus. This review explores the important implications of the rising prevalence of the SARS-CoV-2 Omicron subvariant for public health in Singapore and beyond. |
| format | Article |
| id | doaj-art-2b8a4c5652964dacbe80da3fa83cbedd |
| institution | Kabale University |
| issn | 0037-5675 2737-5935 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wolters Kluwer – Medknow Publications |
| record_format | Article |
| series | Singapore Medical Journal |
| spelling | doaj-art-2b8a4c5652964dacbe80da3fa83cbedd2025-02-09T10:28:25ZengWolters Kluwer – Medknow PublicationsSingapore Medical Journal0037-56752737-59352024-12-01651265866410.4103/singaporemedj.SMJ-2022-180Does the COVID-19 XBB Omicron subvariant signal the beginning of the end of the pandemic?Jinghao Nicholas NgiamAbdurrahmaan Al-MubaarakSebastian Maurer-StrohPaul Anantharajah TambyahAll pandemic viruses have eventually adapted to human hosts so that they become more transmissible and less virulent. The XBB Omicron subvariant is rapidly becoming the dominant strain of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) in Singapore from October 2022 and is one of several variants circulating globally with the potential to dominate autumn/winter waves in different countries. The XBB Omicron subvariant has demonstrated increased transmissibility through an apparent propensity for immune evasion. This is to be expected in the natural evolution of a virus in a population highly vaccinated with a vaccine targeting the spike protein of the original Wuhan strain of the virus. This review explores the important implications of the rising prevalence of the SARS-CoV-2 Omicron subvariant for public health in Singapore and beyond.https://journals.lww.com/10.4103/singaporemedj.SMJ-2022-180covid-19omicronsingaporesubvariantxbb |
| spellingShingle | Jinghao Nicholas Ngiam Abdurrahmaan Al-Mubaarak Sebastian Maurer-Stroh Paul Anantharajah Tambyah Does the COVID-19 XBB Omicron subvariant signal the beginning of the end of the pandemic? Singapore Medical Journal covid-19 omicron singapore subvariant xbb |
| title | Does the COVID-19 XBB Omicron subvariant signal the beginning of the end of the pandemic? |
| title_full | Does the COVID-19 XBB Omicron subvariant signal the beginning of the end of the pandemic? |
| title_fullStr | Does the COVID-19 XBB Omicron subvariant signal the beginning of the end of the pandemic? |
| title_full_unstemmed | Does the COVID-19 XBB Omicron subvariant signal the beginning of the end of the pandemic? |
| title_short | Does the COVID-19 XBB Omicron subvariant signal the beginning of the end of the pandemic? |
| title_sort | does the covid 19 xbb omicron subvariant signal the beginning of the end of the pandemic |
| topic | covid-19 omicron singapore subvariant xbb |
| url | https://journals.lww.com/10.4103/singaporemedj.SMJ-2022-180 |
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