Advances in engineered T cell immunotherapy for autoimmune and other non-oncological diseases
Abstract Adoptive immunotherapy using engineered T cells expressing chimeric antigen receptors has shown remarkable success in treating patients with hematological malignancies. However, realizing broader therapeutic applications of engineered T cells in other diseases requires further exploration i...
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| Format: | Article |
| Language: | English |
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BMC
2025-02-01
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| Series: | Biomarker Research |
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| Online Access: | https://doi.org/10.1186/s40364-025-00736-8 |
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| _version_ | 1823861707647221760 |
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| author | Qiaolin Huang Xiaojian Zhu Yicheng Zhang |
| author_facet | Qiaolin Huang Xiaojian Zhu Yicheng Zhang |
| author_sort | Qiaolin Huang |
| collection | DOAJ |
| description | Abstract Adoptive immunotherapy using engineered T cells expressing chimeric antigen receptors has shown remarkable success in treating patients with hematological malignancies. However, realizing broader therapeutic applications of engineered T cells in other diseases requires further exploration in clinical investigations. In this review, we highlight recent advances in the engineering of T cells in non-oncology areas, including autoimmune and inflammatory diseases, infections, fibrosis, hemophilia, and aging. Chimeric antigen receptor immunotherapy has shown good outcomes in non-oncology areas, but many challenges remain in improving its safety and efficacy and and expanding its application to the treatment of non-oncological diseases. |
| format | Article |
| id | doaj-art-2bc33bd86e0e409b8a663677038b3688 |
| institution | Kabale University |
| issn | 2050-7771 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Biomarker Research |
| spelling | doaj-art-2bc33bd86e0e409b8a663677038b36882025-02-09T12:48:23ZengBMCBiomarker Research2050-77712025-02-0113112210.1186/s40364-025-00736-8Advances in engineered T cell immunotherapy for autoimmune and other non-oncological diseasesQiaolin Huang0Xiaojian Zhu1Yicheng Zhang2Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyAbstract Adoptive immunotherapy using engineered T cells expressing chimeric antigen receptors has shown remarkable success in treating patients with hematological malignancies. However, realizing broader therapeutic applications of engineered T cells in other diseases requires further exploration in clinical investigations. In this review, we highlight recent advances in the engineering of T cells in non-oncology areas, including autoimmune and inflammatory diseases, infections, fibrosis, hemophilia, and aging. Chimeric antigen receptor immunotherapy has shown good outcomes in non-oncology areas, but many challenges remain in improving its safety and efficacy and and expanding its application to the treatment of non-oncological diseases.https://doi.org/10.1186/s40364-025-00736-8Engineering T cellsCAR T cell therapyAutoimmune diseasesFibrosisAging |
| spellingShingle | Qiaolin Huang Xiaojian Zhu Yicheng Zhang Advances in engineered T cell immunotherapy for autoimmune and other non-oncological diseases Biomarker Research Engineering T cells CAR T cell therapy Autoimmune diseases Fibrosis Aging |
| title | Advances in engineered T cell immunotherapy for autoimmune and other non-oncological diseases |
| title_full | Advances in engineered T cell immunotherapy for autoimmune and other non-oncological diseases |
| title_fullStr | Advances in engineered T cell immunotherapy for autoimmune and other non-oncological diseases |
| title_full_unstemmed | Advances in engineered T cell immunotherapy for autoimmune and other non-oncological diseases |
| title_short | Advances in engineered T cell immunotherapy for autoimmune and other non-oncological diseases |
| title_sort | advances in engineered t cell immunotherapy for autoimmune and other non oncological diseases |
| topic | Engineering T cells CAR T cell therapy Autoimmune diseases Fibrosis Aging |
| url | https://doi.org/10.1186/s40364-025-00736-8 |
| work_keys_str_mv | AT qiaolinhuang advancesinengineeredtcellimmunotherapyforautoimmuneandothernononcologicaldiseases AT xiaojianzhu advancesinengineeredtcellimmunotherapyforautoimmuneandothernononcologicaldiseases AT yichengzhang advancesinengineeredtcellimmunotherapyforautoimmuneandothernononcologicaldiseases |