Multi-trace elements-enriched functional drink accelerates gastric ulcer repair via the HGF/c-Met/STAT3 pathway
Heavy alcohol consumption can lead to various gastrointestinal disorders, with gastric ulcers being the most prevalent. In this study, we explored the reparative effects of a functional drink (FD) enriched with trace elements (TEs) on ethanol-induced gastric ulcers in rats and elucidated its underly...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-02-01
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| Series: | Journal of Functional Foods |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464625000167 |
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| author | Yongnan Piao Nuoya Wang Mingji Jin Jianyu Piao Mingfeng Han Zifei Wang Chunhua Quan Jishan Yin Zhonggao Gao Wenxiang Cui Shuangqing Wang Xiuquan Quan |
| author_facet | Yongnan Piao Nuoya Wang Mingji Jin Jianyu Piao Mingfeng Han Zifei Wang Chunhua Quan Jishan Yin Zhonggao Gao Wenxiang Cui Shuangqing Wang Xiuquan Quan |
| author_sort | Yongnan Piao |
| collection | DOAJ |
| description | Heavy alcohol consumption can lead to various gastrointestinal disorders, with gastric ulcers being the most prevalent. In this study, we explored the reparative effects of a functional drink (FD) enriched with trace elements (TEs) on ethanol-induced gastric ulcers in rats and elucidated its underlying mechanism. Rats were administered anhydrous ethanol (5 mL/kg) orally to induce gastric ulcers and were then randomly assigned to a model, an omeprazole (OME, 20 mg/kg), FD with low-dose (FD-L), medium-dose (FD-M), high-dose (FD-H), FD without added TEs (FD without TEs), and an omeprazole+low-dose group (OME + L). FD increased the activities of antioxidant factors (T-SOD, GSH, CAT, and IL-10), and decreased the inflammatory factors levels (TNF-α, IL-6, MDA, COX-2, and iNOS) by promoting the HGF/c-Met/STAT3 pathway. It also effectively regulate the abundance and diversity of intestinal flora. Finally, FD reduced the severity of gastric mucosal injury caused by invasive factors, improved the morphological structure of gastric mucosal cells, enhanced the ability of oxidative stress, and inhibited excessive inflammatory response. In addition, the combination of OME and FD-L did not significantly affect the therapeutic efficacy of OME, but reduced its adverse effects. Ultimately, FD presentation had a pro-healing effect on the ethanol-induced gastric ulcer model. In conclusion, FD has a wide range of developmental prospects and offers an attractive approach and protocol for the treatment of clinical gastric ulcers. |
| format | Article |
| id | doaj-art-2c5a13a2bf354f61ab60b48f925e1a7b |
| institution | Kabale University |
| issn | 1756-4646 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj-art-2c5a13a2bf354f61ab60b48f925e1a7b2025-02-09T04:59:55ZengElsevierJournal of Functional Foods1756-46462025-02-01125106674Multi-trace elements-enriched functional drink accelerates gastric ulcer repair via the HGF/c-Met/STAT3 pathwayYongnan Piao0Nuoya Wang1Mingji Jin2Jianyu Piao3Mingfeng Han4Zifei Wang5Chunhua Quan6Jishan Yin7Zhonggao Gao8Wenxiang Cui9Shuangqing Wang10Xiuquan Quan11Emergency Department, Yanbian Univercity Hospital, Yanji 133000, China; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China; Beijing Key Laboratory of Drug Delivery Technology and Novel Formulations, Department of Pharmaceutics, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, ChinaState Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China; Beijing Key Laboratory of Drug Delivery Technology and Novel Formulations, Department of Pharmaceutics, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, ChinaState Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China; Beijing Key Laboratory of Drug Delivery Technology and Novel Formulations, Department of Pharmaceutics, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, ChinaSchool of Basic Medical Sciences, Capital Medical University, Beijing 100069, ChinaState Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China; Beijing Key Laboratory of Drug Delivery Technology and Novel Formulations, Department of Pharmaceutics, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, ChinaEmergency Department, Yanbian Univercity Hospital, Yanji 133000, ChinaEmergency Department, Yanbian Univercity Hospital, Yanji 133000, ChinaBeijing JINSHAN Ecological Power element Manufactu Co., Ltd, Beijing 101300, ChinaState Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China; Beijing Key Laboratory of Drug Delivery Technology and Novel Formulations, Department of Pharmaceutics, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, ChinaSchool of Nursing, Yanbian University, Yanji 133000, China; Corresponding authors.State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China; Beijing Key Laboratory of Drug Delivery Technology and Novel Formulations, Department of Pharmaceutics, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China; Corresponding author at: Emergency Department, Yanbian Univercity Hospital, Yanji 133000, China.Emergency Department, Yanbian Univercity Hospital, Yanji 133000, China; Corresponding authors.Heavy alcohol consumption can lead to various gastrointestinal disorders, with gastric ulcers being the most prevalent. In this study, we explored the reparative effects of a functional drink (FD) enriched with trace elements (TEs) on ethanol-induced gastric ulcers in rats and elucidated its underlying mechanism. Rats were administered anhydrous ethanol (5 mL/kg) orally to induce gastric ulcers and were then randomly assigned to a model, an omeprazole (OME, 20 mg/kg), FD with low-dose (FD-L), medium-dose (FD-M), high-dose (FD-H), FD without added TEs (FD without TEs), and an omeprazole+low-dose group (OME + L). FD increased the activities of antioxidant factors (T-SOD, GSH, CAT, and IL-10), and decreased the inflammatory factors levels (TNF-α, IL-6, MDA, COX-2, and iNOS) by promoting the HGF/c-Met/STAT3 pathway. It also effectively regulate the abundance and diversity of intestinal flora. Finally, FD reduced the severity of gastric mucosal injury caused by invasive factors, improved the morphological structure of gastric mucosal cells, enhanced the ability of oxidative stress, and inhibited excessive inflammatory response. In addition, the combination of OME and FD-L did not significantly affect the therapeutic efficacy of OME, but reduced its adverse effects. Ultimately, FD presentation had a pro-healing effect on the ethanol-induced gastric ulcer model. In conclusion, FD has a wide range of developmental prospects and offers an attractive approach and protocol for the treatment of clinical gastric ulcers.http://www.sciencedirect.com/science/article/pii/S1756464625000167Gastric ulcerTrace elementsFunctional drinksOxidative stress |
| spellingShingle | Yongnan Piao Nuoya Wang Mingji Jin Jianyu Piao Mingfeng Han Zifei Wang Chunhua Quan Jishan Yin Zhonggao Gao Wenxiang Cui Shuangqing Wang Xiuquan Quan Multi-trace elements-enriched functional drink accelerates gastric ulcer repair via the HGF/c-Met/STAT3 pathway Journal of Functional Foods Gastric ulcer Trace elements Functional drinks Oxidative stress |
| title | Multi-trace elements-enriched functional drink accelerates gastric ulcer repair via the HGF/c-Met/STAT3 pathway |
| title_full | Multi-trace elements-enriched functional drink accelerates gastric ulcer repair via the HGF/c-Met/STAT3 pathway |
| title_fullStr | Multi-trace elements-enriched functional drink accelerates gastric ulcer repair via the HGF/c-Met/STAT3 pathway |
| title_full_unstemmed | Multi-trace elements-enriched functional drink accelerates gastric ulcer repair via the HGF/c-Met/STAT3 pathway |
| title_short | Multi-trace elements-enriched functional drink accelerates gastric ulcer repair via the HGF/c-Met/STAT3 pathway |
| title_sort | multi trace elements enriched functional drink accelerates gastric ulcer repair via the hgf c met stat3 pathway |
| topic | Gastric ulcer Trace elements Functional drinks Oxidative stress |
| url | http://www.sciencedirect.com/science/article/pii/S1756464625000167 |
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