Correlation of clinically significant prostate cancer sites across multiparametric MRI, prostate biopsy, and whole-mount pathology for optimal prostate biopsy strategy
Abstract Data from patients with suspicious lesions on multiparametric magnetic resonance (mpMRI) and a diagnosis of clinically significant prostate cancer (csPCa) who underwent radical prostatectomy (RP) were collected. The aim was to compare csPCa sites identified through whole-mount pathological...
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Nature Portfolio
2025-02-01
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| Online Access: | https://doi.org/10.1038/s41598-025-88463-w |
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| author | Matteo Pacini Alessandro Zucchi Riccardo Morganti Filippo Dazzi Antonio Luigi Pastore Fabio Maria Valenzi Andrea Fuschi Yazan al Salhi Gianluca Giannarini Vincenzo Ficarra Alchiede Simonato Petar Antonov Pinuccia Faviana Riccardo Bartoletti |
| author_facet | Matteo Pacini Alessandro Zucchi Riccardo Morganti Filippo Dazzi Antonio Luigi Pastore Fabio Maria Valenzi Andrea Fuschi Yazan al Salhi Gianluca Giannarini Vincenzo Ficarra Alchiede Simonato Petar Antonov Pinuccia Faviana Riccardo Bartoletti |
| author_sort | Matteo Pacini |
| collection | DOAJ |
| description | Abstract Data from patients with suspicious lesions on multiparametric magnetic resonance (mpMRI) and a diagnosis of clinically significant prostate cancer (csPCa) who underwent radical prostatectomy (RP) were collected. The aim was to compare csPCa sites identified through whole-mount pathological analysis (WMA) after RP with PI-RADS ≥ 3 lesions identified on mpMRI, and with csPCa foci detected through targeted-biopsy (TB) or combined targeted + systematic biopsy (TSB). A paired Student’s t-test and Pearson correlation analysis were performed to evaluate the agreement between these diagnostic methods. A total of 106 patients were included in the TSB group and 95 in the TB group. The correlation between mpMRI, PB, and WMA was moderate and comparable in both groups. No correlation between PB and WMA was found in the TB group for PI-RADS3 lesions, while a moderate-strong correlation was observed when comparing mpMRI, PB, and WMA for PI-RADS > 3 lesions. About 50% of csPCa sites remained undetected by mpMRI. TSB was able to identify 16.5% more csPCa sites than TB. mpMRI is an accurate method in the diagnosis of PCa, especially for PI-RADS > 3 lesions, although some csPCa sites remained undetected. The use of TSB improved the location agreement between PB and WMA, increasing detection rates up to 79%. |
| format | Article |
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| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Nature Portfolio |
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| spelling | doaj-art-2c9701c1bc484db7af39f86d2d72897d2025-02-09T12:29:44ZengNature PortfolioScientific Reports2045-23222025-02-011511910.1038/s41598-025-88463-wCorrelation of clinically significant prostate cancer sites across multiparametric MRI, prostate biopsy, and whole-mount pathology for optimal prostate biopsy strategyMatteo Pacini0Alessandro Zucchi1Riccardo Morganti2Filippo Dazzi3Antonio Luigi Pastore4Fabio Maria Valenzi5Andrea Fuschi6Yazan al Salhi7Gianluca Giannarini8Vincenzo Ficarra9Alchiede Simonato10Petar Antonov11Pinuccia Faviana12Riccardo Bartoletti13Department of Translational Research and New Technologies in Medicine and Surgery, University of PisaDepartment of Translational Research and New Technologies in Medicine and Surgery, University of PisaAzienda Ospedaliero Universitaria Pisana, UO statisticaDepartment of Translational Research and New Technologies in Medicine and Surgery, University of PisaDepartment of Medical and Surgical Science and Biotechnology, La Sapienza UniversityDepartment of Medical and Surgical Science and Biotechnology, La Sapienza UniversityDepartment of Medical and Surgical Science and Biotechnology, La Sapienza UniversityDepartment of Medical and Surgical Science and Biotechnology, La Sapienza UniversityUrology Unit, Santa Maria della Misericordia University HospitalDepartment of Clinical and Experimental Medicinel, University of MessinaDepartment of Precision Medicine in Medical, Surgical and Critical Area, University of PalermoDepartment of Urology and General Medicine, Medical University of PlovdivDepartment of Department of Surgery, Medical, Molecular, and Critical Area, University of PisaDepartment of Translational Research and New Technologies in Medicine and Surgery, University of PisaAbstract Data from patients with suspicious lesions on multiparametric magnetic resonance (mpMRI) and a diagnosis of clinically significant prostate cancer (csPCa) who underwent radical prostatectomy (RP) were collected. The aim was to compare csPCa sites identified through whole-mount pathological analysis (WMA) after RP with PI-RADS ≥ 3 lesions identified on mpMRI, and with csPCa foci detected through targeted-biopsy (TB) or combined targeted + systematic biopsy (TSB). A paired Student’s t-test and Pearson correlation analysis were performed to evaluate the agreement between these diagnostic methods. A total of 106 patients were included in the TSB group and 95 in the TB group. The correlation between mpMRI, PB, and WMA was moderate and comparable in both groups. No correlation between PB and WMA was found in the TB group for PI-RADS3 lesions, while a moderate-strong correlation was observed when comparing mpMRI, PB, and WMA for PI-RADS > 3 lesions. About 50% of csPCa sites remained undetected by mpMRI. TSB was able to identify 16.5% more csPCa sites than TB. mpMRI is an accurate method in the diagnosis of PCa, especially for PI-RADS > 3 lesions, although some csPCa sites remained undetected. The use of TSB improved the location agreement between PB and WMA, increasing detection rates up to 79%.https://doi.org/10.1038/s41598-025-88463-wProstate cancer diagnosisMultiparametric magnetic resonanceTargeted fusion prostate biopsySystematic prostate biopsyWhole mount pathological analysis |
| spellingShingle | Matteo Pacini Alessandro Zucchi Riccardo Morganti Filippo Dazzi Antonio Luigi Pastore Fabio Maria Valenzi Andrea Fuschi Yazan al Salhi Gianluca Giannarini Vincenzo Ficarra Alchiede Simonato Petar Antonov Pinuccia Faviana Riccardo Bartoletti Correlation of clinically significant prostate cancer sites across multiparametric MRI, prostate biopsy, and whole-mount pathology for optimal prostate biopsy strategy Scientific Reports Prostate cancer diagnosis Multiparametric magnetic resonance Targeted fusion prostate biopsy Systematic prostate biopsy Whole mount pathological analysis |
| title | Correlation of clinically significant prostate cancer sites across multiparametric MRI, prostate biopsy, and whole-mount pathology for optimal prostate biopsy strategy |
| title_full | Correlation of clinically significant prostate cancer sites across multiparametric MRI, prostate biopsy, and whole-mount pathology for optimal prostate biopsy strategy |
| title_fullStr | Correlation of clinically significant prostate cancer sites across multiparametric MRI, prostate biopsy, and whole-mount pathology for optimal prostate biopsy strategy |
| title_full_unstemmed | Correlation of clinically significant prostate cancer sites across multiparametric MRI, prostate biopsy, and whole-mount pathology for optimal prostate biopsy strategy |
| title_short | Correlation of clinically significant prostate cancer sites across multiparametric MRI, prostate biopsy, and whole-mount pathology for optimal prostate biopsy strategy |
| title_sort | correlation of clinically significant prostate cancer sites across multiparametric mri prostate biopsy and whole mount pathology for optimal prostate biopsy strategy |
| topic | Prostate cancer diagnosis Multiparametric magnetic resonance Targeted fusion prostate biopsy Systematic prostate biopsy Whole mount pathological analysis |
| url | https://doi.org/10.1038/s41598-025-88463-w |
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