The role of candidate genetic polymorphisms in covid-19 susceptibility and outcomes
Abstract Background This study aims to investigate the association between candidate host genetic polymorphisms and COVID-19 susceptibility, severity, hospitalization, hypoxia, and their combined effect, measured by the polygenic risk score (PRS). Methods Three hundred and seventy-six Lebanese parti...
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BMC
2025-02-01
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| Series: | BMC Medical Genomics |
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| Online Access: | https://doi.org/10.1186/s12920-025-02094-8 |
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| author | Anthony Yazbeck Reem Akika Zainab Awada Nathalie K. Zgheib |
| author_facet | Anthony Yazbeck Reem Akika Zainab Awada Nathalie K. Zgheib |
| author_sort | Anthony Yazbeck |
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| description | Abstract Background This study aims to investigate the association between candidate host genetic polymorphisms and COVID-19 susceptibility, severity, hospitalization, hypoxia, and their combined effect, measured by the polygenic risk score (PRS). Methods Three hundred and seventy-six Lebanese participants, comprising 151 controls and 225 cases, were included. Clinical data were obtained from questionnaires and medical records. DNA isolated from peripheral blood was genotyped for ACE1 rs1799752, ACE2 rs2074192, TMPRSS2 rs75603675 and OAS1 rs107746771 using TaqMan assays, and for TMPRSS2 rs35074065 using Sanger Sequencing. Candidate genetic variants were analyzed in association with COVID-19 susceptibility, severity, hospitalization and hypoxia, using univariate and multivariate models. PRS constructed from the weighted sum of variants was evaluated in association with COVID-19 outcomes. Results In this study, there were no statistically significant differences in the frequencies of candidate variant alleles between cases, controls and within disease outcomes subgroups, after adjustment for confounders. PRS was not associated with COVID-19 susceptibility and hospitalization, it however significantly predicted COVID-19 severity (P = 0.01). Conclusion This study highlights the importance of genetic testing for key host genes involved in COVID-19 life cycle and eventually measuring the PRS which proves to be an important tool for prognosis assessment in vulnerable individuals, potentially enhancing patient care. |
| format | Article |
| id | doaj-art-2cf907f709c84101a4aaaa2200ec33da |
| institution | Kabale University |
| issn | 1755-8794 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMC |
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| series | BMC Medical Genomics |
| spelling | doaj-art-2cf907f709c84101a4aaaa2200ec33da2025-02-09T12:58:54ZengBMCBMC Medical Genomics1755-87942025-02-011811710.1186/s12920-025-02094-8The role of candidate genetic polymorphisms in covid-19 susceptibility and outcomesAnthony Yazbeck0Reem Akika1Zainab Awada2Nathalie K. Zgheib3Faculty of Medicine, American University of BeirutDepartment of Pharmacology and Toxicology, Faculty of Medicine, American University of BeirutResearch Department, Sidra MedicineDepartment of Pharmacology and Toxicology, Faculty of Medicine, American University of BeirutAbstract Background This study aims to investigate the association between candidate host genetic polymorphisms and COVID-19 susceptibility, severity, hospitalization, hypoxia, and their combined effect, measured by the polygenic risk score (PRS). Methods Three hundred and seventy-six Lebanese participants, comprising 151 controls and 225 cases, were included. Clinical data were obtained from questionnaires and medical records. DNA isolated from peripheral blood was genotyped for ACE1 rs1799752, ACE2 rs2074192, TMPRSS2 rs75603675 and OAS1 rs107746771 using TaqMan assays, and for TMPRSS2 rs35074065 using Sanger Sequencing. Candidate genetic variants were analyzed in association with COVID-19 susceptibility, severity, hospitalization and hypoxia, using univariate and multivariate models. PRS constructed from the weighted sum of variants was evaluated in association with COVID-19 outcomes. Results In this study, there were no statistically significant differences in the frequencies of candidate variant alleles between cases, controls and within disease outcomes subgroups, after adjustment for confounders. PRS was not associated with COVID-19 susceptibility and hospitalization, it however significantly predicted COVID-19 severity (P = 0.01). Conclusion This study highlights the importance of genetic testing for key host genes involved in COVID-19 life cycle and eventually measuring the PRS which proves to be an important tool for prognosis assessment in vulnerable individuals, potentially enhancing patient care.https://doi.org/10.1186/s12920-025-02094-8Genetic polymorphismsCOVID-19SusceptibilitySeverityPolygenic risk score |
| spellingShingle | Anthony Yazbeck Reem Akika Zainab Awada Nathalie K. Zgheib The role of candidate genetic polymorphisms in covid-19 susceptibility and outcomes BMC Medical Genomics Genetic polymorphisms COVID-19 Susceptibility Severity Polygenic risk score |
| title | The role of candidate genetic polymorphisms in covid-19 susceptibility and outcomes |
| title_full | The role of candidate genetic polymorphisms in covid-19 susceptibility and outcomes |
| title_fullStr | The role of candidate genetic polymorphisms in covid-19 susceptibility and outcomes |
| title_full_unstemmed | The role of candidate genetic polymorphisms in covid-19 susceptibility and outcomes |
| title_short | The role of candidate genetic polymorphisms in covid-19 susceptibility and outcomes |
| title_sort | role of candidate genetic polymorphisms in covid 19 susceptibility and outcomes |
| topic | Genetic polymorphisms COVID-19 Susceptibility Severity Polygenic risk score |
| url | https://doi.org/10.1186/s12920-025-02094-8 |
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