Iron depletion in “metabolic fatty liver syndromes”: a strong biological rationale with disappointing liver outcomes
Nonalcoholic fatty liver disease (NAFLD), its more rapidly progressive steatohepatitic variant [nonalcoholic steatohepatitis, (NASH)], and the recently defined metabolic dysfunction-associated fatty liver disease (MAFLD) may be collectively alluded to as “metabolic fatty liver syndromes” (MFLS). MFL...
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Open Exploration
2023-08-01
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| Series: | Exploration of Drug Science |
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| Online Access: | https://www.explorationpub.com/uploads/Article/A100816/100816.pdf |
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| author | Amedeo Lonardo |
| author_facet | Amedeo Lonardo |
| author_sort | Amedeo Lonardo |
| collection | DOAJ |
| description | Nonalcoholic fatty liver disease (NAFLD), its more rapidly progressive steatohepatitic variant [nonalcoholic steatohepatitis, (NASH)], and the recently defined metabolic dysfunction-associated fatty liver disease (MAFLD) may be collectively alluded to as “metabolic fatty liver syndromes” (MFLS). MFLS is a common clinical complaint for which no licensed drug treatment is available and a public health issue posing a heaven burden on healthcare systems. Iron plays a key role in many of the key pathogenic steps concurring in the development and progression of MFLS, notably including genetics, intestinal dysbiosis, adipositis, insulin resistance, metaflammation, oxidative stress and ferroptosis, endoplasmic reticulum stress, and hepatic fibrosis. This notion raises the logical expectation that iron depletion, which can easily be implemented with venesection, might improve several aspects of MFLS. However, few published studies have globally failed to support these expectations. In conclusion, venesection in MFLS exhibits a strong biological rationale and possible metabolic benefits. However, confronted with failures in hepato-histological outcomes, data call for additional studies aimed to reconcile these inconsistencies. |
| format | Article |
| id | doaj-art-2d70ab24afbb43acab46adc19e988c47 |
| institution | Kabale University |
| issn | 2836-7677 |
| language | English |
| publishDate | 2023-08-01 |
| publisher | Open Exploration |
| record_format | Article |
| series | Exploration of Drug Science |
| spelling | doaj-art-2d70ab24afbb43acab46adc19e988c472025-02-08T05:16:47ZengOpen ExplorationExploration of Drug Science2836-76772023-08-011423925210.37349/eds.2023.00016Iron depletion in “metabolic fatty liver syndromes”: a strong biological rationale with disappointing liver outcomesAmedeo Lonardo0https://orcid.org/0000-0001-9886-0698Department of Internal Medicine, Azienda Ospedaliero-Universitaria, 41100 Modena, ItalyNonalcoholic fatty liver disease (NAFLD), its more rapidly progressive steatohepatitic variant [nonalcoholic steatohepatitis, (NASH)], and the recently defined metabolic dysfunction-associated fatty liver disease (MAFLD) may be collectively alluded to as “metabolic fatty liver syndromes” (MFLS). MFLS is a common clinical complaint for which no licensed drug treatment is available and a public health issue posing a heaven burden on healthcare systems. Iron plays a key role in many of the key pathogenic steps concurring in the development and progression of MFLS, notably including genetics, intestinal dysbiosis, adipositis, insulin resistance, metaflammation, oxidative stress and ferroptosis, endoplasmic reticulum stress, and hepatic fibrosis. This notion raises the logical expectation that iron depletion, which can easily be implemented with venesection, might improve several aspects of MFLS. However, few published studies have globally failed to support these expectations. In conclusion, venesection in MFLS exhibits a strong biological rationale and possible metabolic benefits. However, confronted with failures in hepato-histological outcomes, data call for additional studies aimed to reconcile these inconsistencies.https://www.explorationpub.com/uploads/Article/A100816/100816.pdfdysmetabolic hyperferritinemiadysmetabolic iron overload syndromeferroptosisinsulin resistance–associated hepatic iron overloadintestinal dysbiosisiron depletion |
| spellingShingle | Amedeo Lonardo Iron depletion in “metabolic fatty liver syndromes”: a strong biological rationale with disappointing liver outcomes Exploration of Drug Science dysmetabolic hyperferritinemia dysmetabolic iron overload syndrome ferroptosis insulin resistance–associated hepatic iron overload intestinal dysbiosis iron depletion |
| title | Iron depletion in “metabolic fatty liver syndromes”: a strong biological rationale with disappointing liver outcomes |
| title_full | Iron depletion in “metabolic fatty liver syndromes”: a strong biological rationale with disappointing liver outcomes |
| title_fullStr | Iron depletion in “metabolic fatty liver syndromes”: a strong biological rationale with disappointing liver outcomes |
| title_full_unstemmed | Iron depletion in “metabolic fatty liver syndromes”: a strong biological rationale with disappointing liver outcomes |
| title_short | Iron depletion in “metabolic fatty liver syndromes”: a strong biological rationale with disappointing liver outcomes |
| title_sort | iron depletion in metabolic fatty liver syndromes a strong biological rationale with disappointing liver outcomes |
| topic | dysmetabolic hyperferritinemia dysmetabolic iron overload syndrome ferroptosis insulin resistance–associated hepatic iron overload intestinal dysbiosis iron depletion |
| url | https://www.explorationpub.com/uploads/Article/A100816/100816.pdf |
| work_keys_str_mv | AT amedeolonardo irondepletioninmetabolicfattyliversyndromesastrongbiologicalrationalewithdisappointingliveroutcomes |