Genetic Evidence for Geographic Structure within the Neanderthal Population
PSMC estimates of Neanderthal effective population size (Ne) exhibit a roughly 5-fold decline across the most recent 20~ky before the death of each fossil. To explain this pattern, this article develops new theory relating genetic variation to geographic population structure and local extinction. It...
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2024-07-01
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| Online Access: | https://peercommunityjournal.org/articles/10.24072/pcjournal.448/ |
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| author | Rogers, Alan R. |
| author_facet | Rogers, Alan R. |
| author_sort | Rogers, Alan R. |
| collection | DOAJ |
| description | PSMC estimates of Neanderthal effective population size (Ne) exhibit a roughly 5-fold decline across the most recent 20~ky before the death of each fossil. To explain this pattern, this article develops new theory relating genetic variation to geographic population structure and local extinction. It argues that the observed pattern results from subdivision and gene flow. If two haploid genomes are sampled from the same subpopulation, their recent ancestors are likely to be geographic neighbors and therefore coalesce rapidly. By contrast, remote ancestors are likely to be far apart, and their coalescent rate is lower. Consequently, Ne is larger in the distant past than in the recent past. New theoretical results show that modest rates of extinction cause substantial reductions in heterozygosity, Wright's FST, and Ne.
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| format | Article |
| id | doaj-art-2d825e5794164651b1391efb0ab87ed2 |
| institution | Kabale University |
| issn | 2804-3871 |
| language | English |
| publishDate | 2024-07-01 |
| publisher | Peer Community In |
| record_format | Article |
| series | Peer Community Journal |
| spelling | doaj-art-2d825e5794164651b1391efb0ab87ed22025-02-07T10:17:18ZengPeer Community InPeer Community Journal2804-38712024-07-01410.24072/pcjournal.44810.24072/pcjournal.448Genetic Evidence for Geographic Structure within the Neanderthal Population Rogers, Alan R.0https://orcid.org/0000-0003-3987-3346University of UtahPSMC estimates of Neanderthal effective population size (Ne) exhibit a roughly 5-fold decline across the most recent 20~ky before the death of each fossil. To explain this pattern, this article develops new theory relating genetic variation to geographic population structure and local extinction. It argues that the observed pattern results from subdivision and gene flow. If two haploid genomes are sampled from the same subpopulation, their recent ancestors are likely to be geographic neighbors and therefore coalesce rapidly. By contrast, remote ancestors are likely to be far apart, and their coalescent rate is lower. Consequently, Ne is larger in the distant past than in the recent past. New theoretical results show that modest rates of extinction cause substantial reductions in heterozygosity, Wright's FST, and Ne. https://peercommunityjournal.org/articles/10.24072/pcjournal.448/Neanderthals; ancient DNA; geographic population structure; extinction; population history |
| spellingShingle | Rogers, Alan R. Genetic Evidence for Geographic Structure within the Neanderthal Population Peer Community Journal Neanderthals; ancient DNA; geographic population structure; extinction; population history |
| title | Genetic Evidence for Geographic Structure within the Neanderthal Population
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| title_full | Genetic Evidence for Geographic Structure within the Neanderthal Population
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| title_fullStr | Genetic Evidence for Geographic Structure within the Neanderthal Population
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| title_full_unstemmed | Genetic Evidence for Geographic Structure within the Neanderthal Population
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| title_short | Genetic Evidence for Geographic Structure within the Neanderthal Population
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| title_sort | genetic evidence for geographic structure within the neanderthal population |
| topic | Neanderthals; ancient DNA; geographic population structure; extinction; population history |
| url | https://peercommunityjournal.org/articles/10.24072/pcjournal.448/ |
| work_keys_str_mv | AT rogersalanr geneticevidenceforgeographicstructurewithintheneanderthalpopulation |