Positive hepatitis B surface antigen leads to a decrease in ovarian reserve in infertile patients receiving first in vitro fertilization treatment
Abstract Background This study assessed the impact of chronic hepatitis B virus (HBV) infection on ovarian reserve in women. Methods We analyzed data from 38,861 infertile women undergoing their first in vitro fertilization (IVF) treatment (2016–2022), including 1574 HBsAg-positive cases. A control...
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2025-02-01
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| Online Access: | https://doi.org/10.1186/s12916-025-03905-6 |
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| author | Yutao Li Xuejiao Wang Ye Jiang Qun Lv Yi Zhang Yu Wang |
| author_facet | Yutao Li Xuejiao Wang Ye Jiang Qun Lv Yi Zhang Yu Wang |
| author_sort | Yutao Li |
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| description | Abstract Background This study assessed the impact of chronic hepatitis B virus (HBV) infection on ovarian reserve in women. Methods We analyzed data from 38,861 infertile women undergoing their first in vitro fertilization (IVF) treatment (2016–2022), including 1574 HBsAg-positive cases. A control group of 1574 HBsAg-negative women was matched by age and body mass index (BMI). Comparison of clinical characteristics, antral follicle count (AFC), follicle-stimulating hormone (FSH), luteinizing hormone (LH)/FSH ratio, anti-Müllerian hormone (AMH), gonadotropins (Gn) days, total Gn dosage, number of retrieved oocytes, number of mature metaphase II (MII) oocytes, and the proportion of patients with diminished ovarian reserve (DOR; AMH < 1.1 ng/ml) between two groups. Results HBsAg-positive women showed lower basal AFC and AMH, higher basal FSH, received more Gn, and had fewer retrieved and MII oocytes than HBsAg-negative women. No significant differences in ovarian reserve or stimulation outcomes were found between e antigen-positive and e antigen-negative HBV-infected groups. DOR was less prevalent in HBsAg-negative women, and logistic regression indicated a higher DOR risk with HBV infection. Conclusions HBsAg positivity significantly impairs ovarian reserve in women, but e antigen status does not notably affect it among HBV-infected individuals. |
| format | Article |
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| institution | Kabale University |
| issn | 1741-7015 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMC |
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| spelling | doaj-art-2f2facc5dfd84010bf5e21d1df9ab1db2025-02-09T12:40:48ZengBMCBMC Medicine1741-70152025-02-012311710.1186/s12916-025-03905-6Positive hepatitis B surface antigen leads to a decrease in ovarian reserve in infertile patients receiving first in vitro fertilization treatmentYutao Li0Xuejiao Wang1Ye Jiang2Qun Lv3Yi Zhang4Yu Wang5Department of Assisted Reproduction Center, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of ChinaDepartment of Assisted Reproduction Center, Sichuan Jinxin Xinan Women and Children’s HospitalDepartment of Gastroenterology, Chengdu Second People’s HospitalDepartment of Gastroenterology, Chengdu Second People’s HospitalDepartment of Assisted Reproduction Center, Sichuan Jinxin Xinan Women and Children’s HospitalDepartment of Assisted Reproduction Center, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of ChinaAbstract Background This study assessed the impact of chronic hepatitis B virus (HBV) infection on ovarian reserve in women. Methods We analyzed data from 38,861 infertile women undergoing their first in vitro fertilization (IVF) treatment (2016–2022), including 1574 HBsAg-positive cases. A control group of 1574 HBsAg-negative women was matched by age and body mass index (BMI). Comparison of clinical characteristics, antral follicle count (AFC), follicle-stimulating hormone (FSH), luteinizing hormone (LH)/FSH ratio, anti-Müllerian hormone (AMH), gonadotropins (Gn) days, total Gn dosage, number of retrieved oocytes, number of mature metaphase II (MII) oocytes, and the proportion of patients with diminished ovarian reserve (DOR; AMH < 1.1 ng/ml) between two groups. Results HBsAg-positive women showed lower basal AFC and AMH, higher basal FSH, received more Gn, and had fewer retrieved and MII oocytes than HBsAg-negative women. No significant differences in ovarian reserve or stimulation outcomes were found between e antigen-positive and e antigen-negative HBV-infected groups. DOR was less prevalent in HBsAg-negative women, and logistic regression indicated a higher DOR risk with HBV infection. Conclusions HBsAg positivity significantly impairs ovarian reserve in women, but e antigen status does not notably affect it among HBV-infected individuals.https://doi.org/10.1186/s12916-025-03905-6Hepatitis B virusOvarian reserveInfertilityIn vitro fertilizationFemale |
| spellingShingle | Yutao Li Xuejiao Wang Ye Jiang Qun Lv Yi Zhang Yu Wang Positive hepatitis B surface antigen leads to a decrease in ovarian reserve in infertile patients receiving first in vitro fertilization treatment BMC Medicine Hepatitis B virus Ovarian reserve Infertility In vitro fertilization Female |
| title | Positive hepatitis B surface antigen leads to a decrease in ovarian reserve in infertile patients receiving first in vitro fertilization treatment |
| title_full | Positive hepatitis B surface antigen leads to a decrease in ovarian reserve in infertile patients receiving first in vitro fertilization treatment |
| title_fullStr | Positive hepatitis B surface antigen leads to a decrease in ovarian reserve in infertile patients receiving first in vitro fertilization treatment |
| title_full_unstemmed | Positive hepatitis B surface antigen leads to a decrease in ovarian reserve in infertile patients receiving first in vitro fertilization treatment |
| title_short | Positive hepatitis B surface antigen leads to a decrease in ovarian reserve in infertile patients receiving first in vitro fertilization treatment |
| title_sort | positive hepatitis b surface antigen leads to a decrease in ovarian reserve in infertile patients receiving first in vitro fertilization treatment |
| topic | Hepatitis B virus Ovarian reserve Infertility In vitro fertilization Female |
| url | https://doi.org/10.1186/s12916-025-03905-6 |
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