Ultrasound evaluation of gallbladder wall thickness for predicting severe dengue: a systematic review and meta-analysis
Abstract Background The prevalence of dengue fever (DF), a mosquito-borne viral disease, is rising worldwide. Its severe manifestations like thrombocytopenia and plasma leakage are associated with increased mortality. Ultrasound-detected gallbladder wall thickening (GBWT) has been suggested as a pot...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2025-02-01
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| Series: | The Ultrasound Journal |
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| Online Access: | https://doi.org/10.1186/s13089-025-00417-5 |
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| author | Amirhossein Shahsavand Davoudi Hamid Harandi Reza Samiee Shayan Forghani Keyhan Mohammadi Maryam Shafaati |
| author_facet | Amirhossein Shahsavand Davoudi Hamid Harandi Reza Samiee Shayan Forghani Keyhan Mohammadi Maryam Shafaati |
| author_sort | Amirhossein Shahsavand Davoudi |
| collection | DOAJ |
| description | Abstract Background The prevalence of dengue fever (DF), a mosquito-borne viral disease, is rising worldwide. Its severe manifestations like thrombocytopenia and plasma leakage are associated with increased mortality. Ultrasound-detected gallbladder wall thickening (GBWT) has been suggested as a potential indicator of the severity of the disease. Aims This systematic review and meta-analysis evaluated the predictive value of GBWT in identifying patients at risk for severe dengue. Methods Following the PRISMA 2020 guidelines, we conducted a systematic search of Web of Science, PubMed, Embase, and Scopus. Among the inclusion criteria were original studies that assessed GBWT across various dengue severity categories. Then, we performed a meta-analysis using a random effects model and subgroup analyses based on severity criteria to determine the relationship between GBWT and severe dengue. Results For the meta-analysis, 19 studies qualified for the inclusion criteria. There was a significant association between GBWT and severe dengue, according to the odds ratio (OR) of 2.35 (95% CI 1.88–2.82, p < 0.001). The subgroup analysis revealed consistent results for thrombocytopenia (OR: 2.65) and plasma leakage (OR: 2.26), among other severity criteria. Conclusions A reliable ultrasound indicator, GBWT can help identify patients at risk for severe dengue early on, improving clinical decision-making and patient outcomes. However, the possibility of differential diagnosis requires cautious interpretation. |
| format | Article |
| id | doaj-art-2fb91637ca904d5cabe3f781ba4474a4 |
| institution | Kabale University |
| issn | 2524-8987 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | The Ultrasound Journal |
| spelling | doaj-art-2fb91637ca904d5cabe3f781ba4474a42025-02-09T12:26:28ZengSpringerOpenThe Ultrasound Journal2524-89872025-02-0117111310.1186/s13089-025-00417-5Ultrasound evaluation of gallbladder wall thickness for predicting severe dengue: a systematic review and meta-analysisAmirhossein Shahsavand Davoudi0Hamid Harandi1Reza Samiee2Shayan Forghani3Keyhan Mohammadi4Maryam Shafaati5School of Medicine, Tehran University of Medical SciencesSchool of Medicine, Tehran University of Medical SciencesSchool of Medicine, Tehran University of Medical SciencesSchool of Medicine, Tehran University of Medical SciencesResearch Center for Antibiotic Stewardship and Antimicrobial Resistance, Infectious Diseases Department, Imam Khomeini Hospital Complex, Tehran University of Medical SciencesResearch Center for Antibiotic Stewardship and Antimicrobial Resistance, Infectious Diseases Department, Imam Khomeini Hospital Complex, Tehran University of Medical SciencesAbstract Background The prevalence of dengue fever (DF), a mosquito-borne viral disease, is rising worldwide. Its severe manifestations like thrombocytopenia and plasma leakage are associated with increased mortality. Ultrasound-detected gallbladder wall thickening (GBWT) has been suggested as a potential indicator of the severity of the disease. Aims This systematic review and meta-analysis evaluated the predictive value of GBWT in identifying patients at risk for severe dengue. Methods Following the PRISMA 2020 guidelines, we conducted a systematic search of Web of Science, PubMed, Embase, and Scopus. Among the inclusion criteria were original studies that assessed GBWT across various dengue severity categories. Then, we performed a meta-analysis using a random effects model and subgroup analyses based on severity criteria to determine the relationship between GBWT and severe dengue. Results For the meta-analysis, 19 studies qualified for the inclusion criteria. There was a significant association between GBWT and severe dengue, according to the odds ratio (OR) of 2.35 (95% CI 1.88–2.82, p < 0.001). The subgroup analysis revealed consistent results for thrombocytopenia (OR: 2.65) and plasma leakage (OR: 2.26), among other severity criteria. Conclusions A reliable ultrasound indicator, GBWT can help identify patients at risk for severe dengue early on, improving clinical decision-making and patient outcomes. However, the possibility of differential diagnosis requires cautious interpretation.https://doi.org/10.1186/s13089-025-00417-5Dengue feverSevere dengueGallbladder wall thickening (GBWT)UltrasoundRisk prediction |
| spellingShingle | Amirhossein Shahsavand Davoudi Hamid Harandi Reza Samiee Shayan Forghani Keyhan Mohammadi Maryam Shafaati Ultrasound evaluation of gallbladder wall thickness for predicting severe dengue: a systematic review and meta-analysis The Ultrasound Journal Dengue fever Severe dengue Gallbladder wall thickening (GBWT) Ultrasound Risk prediction |
| title | Ultrasound evaluation of gallbladder wall thickness for predicting severe dengue: a systematic review and meta-analysis |
| title_full | Ultrasound evaluation of gallbladder wall thickness for predicting severe dengue: a systematic review and meta-analysis |
| title_fullStr | Ultrasound evaluation of gallbladder wall thickness for predicting severe dengue: a systematic review and meta-analysis |
| title_full_unstemmed | Ultrasound evaluation of gallbladder wall thickness for predicting severe dengue: a systematic review and meta-analysis |
| title_short | Ultrasound evaluation of gallbladder wall thickness for predicting severe dengue: a systematic review and meta-analysis |
| title_sort | ultrasound evaluation of gallbladder wall thickness for predicting severe dengue a systematic review and meta analysis |
| topic | Dengue fever Severe dengue Gallbladder wall thickening (GBWT) Ultrasound Risk prediction |
| url | https://doi.org/10.1186/s13089-025-00417-5 |
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