Impact of donor CYP3A5 genotype on pharmacokinetics of tacrolimus in South African paediatric liver transplant patients
Background. In the paediatric liver transplant programme in Johannesburg, South Africa (SA), tacrolimus is the calcineurin inhibitor of choice, comprising an essential component of the immunosuppression regimen. It is characterised by a narrow therapeutic index and wide interpatient variability...
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Main Authors: | C Wheeler, C Masimirembwa, B Mthembu, J Botha, J Scholefield, J Fabian |
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Format: | Article |
Language: | English |
Published: |
South African Medical Association
2024-04-01
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Series: | South African Medical Journal |
Subjects: | |
Online Access: | https://samajournals.co.za/index.php/samj/article/view/1367 |
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