Migraine and subsequent chronic kidney disease risk: a nationwide population-based cohort study
Objective We compared the incidence and risk of chronic kidney disease (CKD) between subjects with new-onset migraine and matched controls without migraine in this large-scale retrospective cohort study.Design Population-based cohort study.Setting 8880 subjects with migraine and 503 070 subjects wit...
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2017-12-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/7/12/e018483.full |
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| author | Ming-Ju Wu Chew-Teng Kor Chia-Chu Chang Shuo-Chun Weng Chia-Lin Wu Ping-Fang Chiu Der-Cherng Tarng |
| author_facet | Ming-Ju Wu Chew-Teng Kor Chia-Chu Chang Shuo-Chun Weng Chia-Lin Wu Ping-Fang Chiu Der-Cherng Tarng |
| author_sort | Ming-Ju Wu |
| collection | DOAJ |
| description | Objective We compared the incidence and risk of chronic kidney disease (CKD) between subjects with new-onset migraine and matched controls without migraine in this large-scale retrospective cohort study.Design Population-based cohort study.Setting 8880 subjects with migraine and 503 070 subjects without migraine were enrolled between January 1, 2000 and December 31, 2013, all diagnosed to be without kidney disease. All the participants were registered in the National Health Insurance Research Database.Participants Finally, data from 7156 subjects with migraine and 7156 propensity-score-matched control subjects were analysed.Primary outcome measure We used Cox proportional hazards regression to estimate adjusted HRs for incident CKD; subgroup analyses were performed to assess the interactive effects of migraine with demographics, comorbidities and long-term medications.Results The incidence of CKD was higher in the migraine group than in the control group. The risk of developing CKD was significantly higher in subjects with migraine than without migraine (P=0.031). Subjects with migraine aged <65 years (age 40–64 (adjusted HR (aHR) 1.35; 95% CI 1.05 to 1.73); age <40 (aHR 1.55; 95% CI 1.02 to 2.36)), with ≥1 comorbid diseases (1–2 diseases (aHR 1.30; 95% CI 1.01 to 1.68); ≥3 diseases (aHR 1.45; 95% CI 1.01 to 2.07)), and not receiving anti-migraine agents (aHR 1.26; 95% CI 1.04 to 1.54) were at a higher risk of developing CKD compared with the control subjects. The interaction between migraine and comorbidities was not significant; age, male gender and long-term use of non-steroidal anti-inflammatory drugs (NSAIDs) were independent risk factors for CKD in subjects with migraine.Conclusion Migraine may be an independent risk factor for CKD. Young subjects with migraine, and those with comorbid conditions or without medical control, are likely to be at higher risk for CKD. Ageing, male sex and NSAIDs tend to have an association with CKD in subjects with migraine. |
| format | Article |
| id | doaj-art-3105349b87dd4e4da8ac4fa4a6e8198b |
| institution | Kabale University |
| issn | 2044-6055 |
| language | English |
| publishDate | 2017-12-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-3105349b87dd4e4da8ac4fa4a6e8198b2025-02-09T08:05:15ZengBMJ Publishing GroupBMJ Open2044-60552017-12-0171210.1136/bmjopen-2017-018483Migraine and subsequent chronic kidney disease risk: a nationwide population-based cohort studyMing-Ju Wu0Chew-Teng Kor1Chia-Chu Chang2Shuo-Chun Weng3Chia-Lin Wu4Ping-Fang Chiu5Der-Cherng Tarng61 Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan5 Internal Medicine Research Center, Changhua Christian Hospital, Changhua, Taiwan3 Department of Internal Medicine, Division of Nephrology, Changhua Christian Hospital, Changhua, Taiwan1 Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan1 Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan4 School of Medicine, Chung-Shan Medical University, Taichung, TaiwanDivision of Nephrology, Department of Medicine, Taipei Veterans General Hospital, Taipei, TaiwanObjective We compared the incidence and risk of chronic kidney disease (CKD) between subjects with new-onset migraine and matched controls without migraine in this large-scale retrospective cohort study.Design Population-based cohort study.Setting 8880 subjects with migraine and 503 070 subjects without migraine were enrolled between January 1, 2000 and December 31, 2013, all diagnosed to be without kidney disease. All the participants were registered in the National Health Insurance Research Database.Participants Finally, data from 7156 subjects with migraine and 7156 propensity-score-matched control subjects were analysed.Primary outcome measure We used Cox proportional hazards regression to estimate adjusted HRs for incident CKD; subgroup analyses were performed to assess the interactive effects of migraine with demographics, comorbidities and long-term medications.Results The incidence of CKD was higher in the migraine group than in the control group. The risk of developing CKD was significantly higher in subjects with migraine than without migraine (P=0.031). Subjects with migraine aged <65 years (age 40–64 (adjusted HR (aHR) 1.35; 95% CI 1.05 to 1.73); age <40 (aHR 1.55; 95% CI 1.02 to 2.36)), with ≥1 comorbid diseases (1–2 diseases (aHR 1.30; 95% CI 1.01 to 1.68); ≥3 diseases (aHR 1.45; 95% CI 1.01 to 2.07)), and not receiving anti-migraine agents (aHR 1.26; 95% CI 1.04 to 1.54) were at a higher risk of developing CKD compared with the control subjects. The interaction between migraine and comorbidities was not significant; age, male gender and long-term use of non-steroidal anti-inflammatory drugs (NSAIDs) were independent risk factors for CKD in subjects with migraine.Conclusion Migraine may be an independent risk factor for CKD. Young subjects with migraine, and those with comorbid conditions or without medical control, are likely to be at higher risk for CKD. Ageing, male sex and NSAIDs tend to have an association with CKD in subjects with migraine.https://bmjopen.bmj.com/content/7/12/e018483.full |
| spellingShingle | Ming-Ju Wu Chew-Teng Kor Chia-Chu Chang Shuo-Chun Weng Chia-Lin Wu Ping-Fang Chiu Der-Cherng Tarng Migraine and subsequent chronic kidney disease risk: a nationwide population-based cohort study BMJ Open |
| title | Migraine and subsequent chronic kidney disease risk: a nationwide population-based cohort study |
| title_full | Migraine and subsequent chronic kidney disease risk: a nationwide population-based cohort study |
| title_fullStr | Migraine and subsequent chronic kidney disease risk: a nationwide population-based cohort study |
| title_full_unstemmed | Migraine and subsequent chronic kidney disease risk: a nationwide population-based cohort study |
| title_short | Migraine and subsequent chronic kidney disease risk: a nationwide population-based cohort study |
| title_sort | migraine and subsequent chronic kidney disease risk a nationwide population based cohort study |
| url | https://bmjopen.bmj.com/content/7/12/e018483.full |
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