Pediatric endoscopic retrograde pancreatography expertise in chronic pancreatitis: a single-center analysis
Background and aimChronic pancreatitis (CP) in children has exhibited an annual increase in incidence in recent years. Pediatric CP presents unique clinical features compared to adult cases. Endoscopic retrograde pancreatography (ERP) serves as a valuable and safe tool for diagnosing and treating CP...
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Pediatrics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2025.1491579/full |
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| author | Hongxi Guo Juan Luo Hu Yang Jun Yang Hongqiang Bian Xufei Duan Xin Wang |
| author_facet | Hongxi Guo Juan Luo Hu Yang Jun Yang Hongqiang Bian Xufei Duan Xin Wang |
| author_sort | Hongxi Guo |
| collection | DOAJ |
| description | Background and aimChronic pancreatitis (CP) in children has exhibited an annual increase in incidence in recent years. Pediatric CP presents unique clinical features compared to adult cases. Endoscopic retrograde pancreatography (ERP) serves as a valuable and safe tool for diagnosing and treating CP in adults. However, data on endoscopic treatment of CP in children are still limited.MethodsDemographics, etiology, surgical indications, diagnosis, treatment details, associated complications, and follow-up information were retrospectively studied in consecutive patients (<18 years old) who underwent ERP for CP between January 2020 and October 2024.ResultsA total of 17 children (7 male, 10 female) with a mean age of 10.0 ± 2.7 years were included in the study. A total of 34 endoscopic treatments were conducted. Recurrent abdominal pain was the primary clinical symptom. Imaging predominantly revealed pancreatic duct abnormalities such as tortuous dilatation and the presence of pancreatic duct stones. Notably, 41.2% (7 cases) involved genetic and congenital anatomical variations. Pancreatic duct stent placement was successfully performed in all 17 children (100.0% success rate). Stent replacements occurred on average 2.2 times (range 1–5) at intervals of 3–6 months. Postoperative pancreatitis developed in 2 cases (5.9%, 2/34), and hyperamylasemia occurred in 5 cases (14.7%, 5/34). The postprocedure visual analogue scale (VAS) score for abdominal pain significantly decreased from 6 to 1 (P < 0.001). The annual frequency of pancreatitis episodes showed a significant reduction, decreasing from 2.4 times pre-treatment to 0.6 times post-treatment (P < 0.05). Body mass index (BMI) also showed a significant improvement post-treatment compared to pre-treatment (P < 0.05).ConclusionsERP performed by trained endoscopists utilizing standard adult endoscopes and accessories proved a safe and effective treatment option for pediatric CP, with complication rates comparable to those reported in adult cases. |
| format | Article |
| id | doaj-art-32b7aa02aca440e19221527e87c09461 |
| institution | Kabale University |
| issn | 2296-2360 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Pediatrics |
| spelling | doaj-art-32b7aa02aca440e19221527e87c094612025-02-11T07:00:10ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602025-02-011310.3389/fped.2025.14915791491579Pediatric endoscopic retrograde pancreatography expertise in chronic pancreatitis: a single-center analysisHongxi Guo0Juan Luo1Hu Yang2Jun Yang3Hongqiang Bian4Xufei Duan5Xin Wang6Department of General Surgery, Wuhan Children’s Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, ChinaDepartment of Endocrinology and Metabolism, Wuhan Children’s Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, ChinaDepartment of General Surgery, Wuhan Children’s Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, ChinaDepartment of General Surgery, Wuhan Children’s Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, ChinaDepartment of General Surgery, Wuhan Children’s Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, ChinaDepartment of General Surgery, Wuhan Children’s Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, ChinaDepartment of General Surgery, Wuhan Children’s Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, ChinaBackground and aimChronic pancreatitis (CP) in children has exhibited an annual increase in incidence in recent years. Pediatric CP presents unique clinical features compared to adult cases. Endoscopic retrograde pancreatography (ERP) serves as a valuable and safe tool for diagnosing and treating CP in adults. However, data on endoscopic treatment of CP in children are still limited.MethodsDemographics, etiology, surgical indications, diagnosis, treatment details, associated complications, and follow-up information were retrospectively studied in consecutive patients (<18 years old) who underwent ERP for CP between January 2020 and October 2024.ResultsA total of 17 children (7 male, 10 female) with a mean age of 10.0 ± 2.7 years were included in the study. A total of 34 endoscopic treatments were conducted. Recurrent abdominal pain was the primary clinical symptom. Imaging predominantly revealed pancreatic duct abnormalities such as tortuous dilatation and the presence of pancreatic duct stones. Notably, 41.2% (7 cases) involved genetic and congenital anatomical variations. Pancreatic duct stent placement was successfully performed in all 17 children (100.0% success rate). Stent replacements occurred on average 2.2 times (range 1–5) at intervals of 3–6 months. Postoperative pancreatitis developed in 2 cases (5.9%, 2/34), and hyperamylasemia occurred in 5 cases (14.7%, 5/34). The postprocedure visual analogue scale (VAS) score for abdominal pain significantly decreased from 6 to 1 (P < 0.001). The annual frequency of pancreatitis episodes showed a significant reduction, decreasing from 2.4 times pre-treatment to 0.6 times post-treatment (P < 0.05). Body mass index (BMI) also showed a significant improvement post-treatment compared to pre-treatment (P < 0.05).ConclusionsERP performed by trained endoscopists utilizing standard adult endoscopes and accessories proved a safe and effective treatment option for pediatric CP, with complication rates comparable to those reported in adult cases.https://www.frontiersin.org/articles/10.3389/fped.2025.1491579/fullendoscopic retrograde pancreatography (ERP)childrenchronic pancreatitis (CP)pancreas divisumpseudocyst |
| spellingShingle | Hongxi Guo Juan Luo Hu Yang Jun Yang Hongqiang Bian Xufei Duan Xin Wang Pediatric endoscopic retrograde pancreatography expertise in chronic pancreatitis: a single-center analysis Frontiers in Pediatrics endoscopic retrograde pancreatography (ERP) children chronic pancreatitis (CP) pancreas divisum pseudocyst |
| title | Pediatric endoscopic retrograde pancreatography expertise in chronic pancreatitis: a single-center analysis |
| title_full | Pediatric endoscopic retrograde pancreatography expertise in chronic pancreatitis: a single-center analysis |
| title_fullStr | Pediatric endoscopic retrograde pancreatography expertise in chronic pancreatitis: a single-center analysis |
| title_full_unstemmed | Pediatric endoscopic retrograde pancreatography expertise in chronic pancreatitis: a single-center analysis |
| title_short | Pediatric endoscopic retrograde pancreatography expertise in chronic pancreatitis: a single-center analysis |
| title_sort | pediatric endoscopic retrograde pancreatography expertise in chronic pancreatitis a single center analysis |
| topic | endoscopic retrograde pancreatography (ERP) children chronic pancreatitis (CP) pancreas divisum pseudocyst |
| url | https://www.frontiersin.org/articles/10.3389/fped.2025.1491579/full |
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