Natural products targeting RAS by multiple mechanisms and its therapeutic potential in cancer: An update since 2020
RAS proteins, as pivotal signal transduction molecules, are frequently mutated and hyperactivated in various human cancers, closely associated with tumor cell proliferation, survival, and metastasis. Despite extensive research on RAS targeted therapies, developing effective RAS inhibitors remains a...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-02-01
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| Series: | Pharmacological Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1043661825000027 |
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| author | Yanqing Liu Jie Chen Xiang Li Yu Fan Cheng Peng Xiaochun Ye Yingshuang Wang Xin Xie |
| author_facet | Yanqing Liu Jie Chen Xiang Li Yu Fan Cheng Peng Xiaochun Ye Yingshuang Wang Xin Xie |
| author_sort | Yanqing Liu |
| collection | DOAJ |
| description | RAS proteins, as pivotal signal transduction molecules, are frequently mutated and hyperactivated in various human cancers, closely associated with tumor cell proliferation, survival, and metastasis. Despite extensive research on RAS targeted therapies, developing effective RAS inhibitors remains a significant challenge. Natural products, endowed with unique chemical structures and diverse biological activities through long-term natural selection, have emerged as a vital resource for discovering novel RAS-targeted therapeutic drugs. This review focuses on the latest advancements in targeting RAS with natural products and categorizes these natural products based on their mechanisms of action. Additionally, we discuss the challenges faced by these natural products during clinical translation, including issues related to pharmacokinetics. Strategies such as combination therapy, structural optimization, and drug delivery systems are anticipated to enhance efficacy and overcome these challenges. |
| format | Article |
| id | doaj-art-3312bda3b5c04c0897d26fcdaf4fdc04 |
| institution | Kabale University |
| issn | 1096-1186 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Pharmacological Research |
| spelling | doaj-art-3312bda3b5c04c0897d26fcdaf4fdc042025-02-08T04:59:38ZengElsevierPharmacological Research1096-11862025-02-01212107577Natural products targeting RAS by multiple mechanisms and its therapeutic potential in cancer: An update since 2020Yanqing Liu0Jie Chen1Xiang Li2Yu Fan3Cheng Peng4Xiaochun Ye5Yingshuang Wang6Xin Xie7Department of Pharmacy, the Thirteenth People's Hospital of Chongqing, Chongqing Geriatrics Hospital, Chongqing 400053, China; Corresponding author.State Key Laboratory of Southwestern Chinese Medicine Resources, College of Medical Technology and School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, ChinaState Key Laboratory of Southwestern Chinese Medicine Resources, College of Medical Technology and School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, ChinaState Key Laboratory of Southwestern Chinese Medicine Resources, College of Medical Technology and School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China; Chongqing Key Laboratory of Sichuan-Chongqing Co-construction for Diagnosis and Treatment of Infectious Diseases Integrated Traditional Chinese and Western Medicine, Chongqing 400021, ChinaState Key Laboratory of Southwestern Chinese Medicine Resources, College of Medical Technology and School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, ChinaDepartment of Pharmacy, the Thirteenth People's Hospital of Chongqing, Chongqing Geriatrics Hospital, Chongqing 400053, ChinaState Key Laboratory of Southwestern Chinese Medicine Resources, College of Medical Technology and School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China; Chongqing Key Laboratory of Sichuan-Chongqing Co-construction for Diagnosis and Treatment of Infectious Diseases Integrated Traditional Chinese and Western Medicine, Chongqing 400021, ChinaState Key Laboratory of Southwestern Chinese Medicine Resources, College of Medical Technology and School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China; Chongqing Key Laboratory of Sichuan-Chongqing Co-construction for Diagnosis and Treatment of Infectious Diseases Integrated Traditional Chinese and Western Medicine, Chongqing 400021, China; Corresponding author at: State Key Laboratory of Southwestern Chinese Medicine Resources, College of Medical Technology and School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.RAS proteins, as pivotal signal transduction molecules, are frequently mutated and hyperactivated in various human cancers, closely associated with tumor cell proliferation, survival, and metastasis. Despite extensive research on RAS targeted therapies, developing effective RAS inhibitors remains a significant challenge. Natural products, endowed with unique chemical structures and diverse biological activities through long-term natural selection, have emerged as a vital resource for discovering novel RAS-targeted therapeutic drugs. This review focuses on the latest advancements in targeting RAS with natural products and categorizes these natural products based on their mechanisms of action. Additionally, we discuss the challenges faced by these natural products during clinical translation, including issues related to pharmacokinetics. Strategies such as combination therapy, structural optimization, and drug delivery systems are anticipated to enhance efficacy and overcome these challenges.http://www.sciencedirect.com/science/article/pii/S1043661825000027RASNatural productsCancerTargeted therapy |
| spellingShingle | Yanqing Liu Jie Chen Xiang Li Yu Fan Cheng Peng Xiaochun Ye Yingshuang Wang Xin Xie Natural products targeting RAS by multiple mechanisms and its therapeutic potential in cancer: An update since 2020 Pharmacological Research RAS Natural products Cancer Targeted therapy |
| title | Natural products targeting RAS by multiple mechanisms and its therapeutic potential in cancer: An update since 2020 |
| title_full | Natural products targeting RAS by multiple mechanisms and its therapeutic potential in cancer: An update since 2020 |
| title_fullStr | Natural products targeting RAS by multiple mechanisms and its therapeutic potential in cancer: An update since 2020 |
| title_full_unstemmed | Natural products targeting RAS by multiple mechanisms and its therapeutic potential in cancer: An update since 2020 |
| title_short | Natural products targeting RAS by multiple mechanisms and its therapeutic potential in cancer: An update since 2020 |
| title_sort | natural products targeting ras by multiple mechanisms and its therapeutic potential in cancer an update since 2020 |
| topic | RAS Natural products Cancer Targeted therapy |
| url | http://www.sciencedirect.com/science/article/pii/S1043661825000027 |
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