Pan-caspase inhibitor protects against noise-induced hearing loss in a rodent model

Pan-caspase inhibitor protects against noise-induced hearing loss in a rodent model

BackgroundDespite the high prevalence of noise-induced hearing loss (NIHL), no effective treatments exist currently. Underlying mechanisms behind NIHL include elevated reactive oxygen species and inflammation, all which ultimately lead to cellular apoptosis. Z-VAD-FMK, an apoptosis inhibitor, has de...

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Bibliographic Details
Main Authors: Maria Fernanda Yepes, Kayla Minesinger, Federica M. Raciti, Maria Camila Salazar, Suhrud M. Rajguru
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-02-01
Series:Frontiers in Neuroscience
Subjects:
NIHL
noise induced hearing loss
cochlea
ABR
auditory brainstem responses
inner ear therapeutics
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2025.1497773/full
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https://www.frontiersin.org/articles/10.3389/fnins.2025.1497773/full

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