The aging hematopoietic stem cell niche: a mini review
Hematopoietic stem cells (HSCs) undergo a functional decline during aging. The intrinsic characteristics of aged HSCs have been well-described and include a strong myeloid bias, an increase in total number, and a decrease in functionality during transplantation. The impact of the aged bone marrow mi...
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Hematology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/frhem.2025.1525132/full |
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| author | Xin Gao Jing Zhang Jing Zhang Owen J. Tamplin |
| author_facet | Xin Gao Jing Zhang Jing Zhang Owen J. Tamplin |
| author_sort | Xin Gao |
| collection | DOAJ |
| description | Hematopoietic stem cells (HSCs) undergo a functional decline during aging. The intrinsic characteristics of aged HSCs have been well-described and include a strong myeloid bias, an increase in total number, and a decrease in functionality during transplantation. The impact of the aged bone marrow microenvironment, or niche, on HSCs is less well understood. It is critical to understand the changing condition of the niche during aging, and its ability to support HSCs, as this could reveal the very signals and mechanisms needed to improve HSC fitness. Furthermore, heterochronic transplantation provides an approach to test the influence of an aged recipient niche on young donor HSCs, and conversely, of a young recipient niche on aged donor HSCs. Importantly, these experiments demonstrated that donor HSC engraftment is reduced if the recipient niche is aged, and conversely, the young niche can rejuvenate aged donor HSCs. Here we will focus on the interactions between aged HSCs and their microenvironment. We will highlight current controversies, research gaps, and future directions. |
| format | Article |
| id | doaj-art-33c66371a9474f7c8d82dd85e50302d4 |
| institution | Kabale University |
| issn | 2813-3935 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Hematology |
| spelling | doaj-art-33c66371a9474f7c8d82dd85e50302d42025-02-07T06:49:58ZengFrontiers Media S.A.Frontiers in Hematology2813-39352025-02-01410.3389/frhem.2025.15251321525132The aging hematopoietic stem cell niche: a mini reviewXin Gao0Jing Zhang1Jing Zhang2Owen J. Tamplin3Department of Pathology and Laboratory Medicine, Wisconsin Blood Cancer Research Institute, University of Wisconsin-Madison, Madison, WI, United StatesMcArdle Laboratory for Cancer Research, University of Wisconsin-Madison, Madison, WI, United StatesCarbone Cancer Center, University of Wisconsin-Madison, Madison, WI, United StatesDepartment of Cell and Regenerative Biology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, United StatesHematopoietic stem cells (HSCs) undergo a functional decline during aging. The intrinsic characteristics of aged HSCs have been well-described and include a strong myeloid bias, an increase in total number, and a decrease in functionality during transplantation. The impact of the aged bone marrow microenvironment, or niche, on HSCs is less well understood. It is critical to understand the changing condition of the niche during aging, and its ability to support HSCs, as this could reveal the very signals and mechanisms needed to improve HSC fitness. Furthermore, heterochronic transplantation provides an approach to test the influence of an aged recipient niche on young donor HSCs, and conversely, of a young recipient niche on aged donor HSCs. Importantly, these experiments demonstrated that donor HSC engraftment is reduced if the recipient niche is aged, and conversely, the young niche can rejuvenate aged donor HSCs. Here we will focus on the interactions between aged HSCs and their microenvironment. We will highlight current controversies, research gaps, and future directions.https://www.frontiersin.org/articles/10.3389/frhem.2025.1525132/fullaginghematopoietic stem cellsnicheinflammationmicroenvironmentimmune function |
| spellingShingle | Xin Gao Jing Zhang Jing Zhang Owen J. Tamplin The aging hematopoietic stem cell niche: a mini review Frontiers in Hematology aging hematopoietic stem cells niche inflammation microenvironment immune function |
| title | The aging hematopoietic stem cell niche: a mini review |
| title_full | The aging hematopoietic stem cell niche: a mini review |
| title_fullStr | The aging hematopoietic stem cell niche: a mini review |
| title_full_unstemmed | The aging hematopoietic stem cell niche: a mini review |
| title_short | The aging hematopoietic stem cell niche: a mini review |
| title_sort | aging hematopoietic stem cell niche a mini review |
| topic | aging hematopoietic stem cells niche inflammation microenvironment immune function |
| url | https://www.frontiersin.org/articles/10.3389/frhem.2025.1525132/full |
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