Pregnancy after kidney and liver transplantation
Pregnancy in kidney and liver transplant recipients presents unique challenges and risks for both maternal and fetal health. This article examines the management of pregnancy in kidney and liver transplant recipients, focusing on pre-pregnancy counselling, trimester-specific care, the teratogen...
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| Format: | Article |
| Language: | English |
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South African Medical Association
2024-04-01
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| Series: | South African Medical Journal |
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| Online Access: | https://samajournals.co.za/index.php/samj/article/view/1240 |
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| author | A Wise N E Diana B Bobat R T Saggers S Bhoora S Budhram L Chauke V G Lala A Mahomed D Mokgoko M Seabi B Moore S Naidoo R B Nyakoe N Odell G Paget L Wium J Zamparini |
| author_facet | A Wise N E Diana B Bobat R T Saggers S Bhoora S Budhram L Chauke V G Lala A Mahomed D Mokgoko M Seabi B Moore S Naidoo R B Nyakoe N Odell G Paget L Wium J Zamparini |
| author_sort | A Wise |
| collection | DOAJ |
| description |
Pregnancy in kidney and liver transplant recipients presents unique challenges and risks for both maternal and fetal health. This article examines the management of pregnancy in kidney and liver transplant recipients, focusing on pre-pregnancy counselling, trimester-specific care, the teratogenic effects of immunosuppressive drugs, and the role of the multidisciplinary team. While South African (SA) data on this topic are limited, the Transplant Pregnancy Registry International has provided valuable insights. Despite the increased risk of maternal and fetal complications, the overall risk of graft loss during pregnancy is low. Graft survival rates are comparable between pregnant and non- pregnant transplant recipients, except for pregnancies occurring within 1 year of transplantation. By addressing the complexities of managing pregnant women with kidney or liver transplants, this article underscores the importance of tailored care and the involvement of various medical specialists. It also explores the safety of and potential complications associated with specific immunosuppressive therapies during pregnancy. Further research is needed to enhance our understanding and optimise the management of these high-risk pregnancies in SA.
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| format | Article |
| id | doaj-art-34cd26b757a841539dd5c8e5be34a281 |
| institution | Kabale University |
| issn | 0256-9574 2078-5135 |
| language | English |
| publishDate | 2024-04-01 |
| publisher | South African Medical Association |
| record_format | Article |
| series | South African Medical Journal |
| spelling | doaj-art-34cd26b757a841539dd5c8e5be34a2812025-02-10T12:26:15ZengSouth African Medical AssociationSouth African Medical Journal0256-95742078-51352024-04-011143b10.7196/SAMJ.2024.v114i3b.1240Pregnancy after kidney and liver transplantationA Wise0https://orcid.org/0000-0001-5182-9060N E Diana1https://orcid.org/0000-0001-6461-8609B Bobat2https://orcid.org/0000-0001-7575-397XR T Saggers3https://orcid.org/0000-0001-6593-8049S Bhoora4https://orcid.org/0000-0003-1804-2690S Budhram5https://orcid.org/0000-0002-5747-1714L Chauke6https://orcid.org/0000-0001-7051-6959V G Lala7https://orcid.org/0000-0003-2543-7025A Mahomed8https://orcid.org/0000-0002-0560-014XD Mokgoko9https://orcid.org/0000-0002-2413-739XM Seabi10https://orcid.org/0000-0002-7841-6466B Moore11https://orcid.org/0009-0007-1224-7552S Naidoo12https://orcid.org/0000-0001-5878-0247R B Nyakoe13https://orcid.org/0000-0002-2618-3111N Odell14https://orcid.org/0009-0006-7545-5175G Paget15https://orcid.org/0000-0002-8274-1157L Wium16https://orcid.org/0000-0001-7949-7651J Zamparini17https://orcid.org/0000-0002-1365-5650Department of Obstetrics and Gynaecology, Rahima Moosa Mother and Child Hospital and Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South AfricaDivision of Nephrology, Department of Internal Medicine, Charlotte Maxeke Johannesburg Academic Hospital and Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South AfricaDepartment of Gastroenterology and Hepatology, Wits Donald Gordon Medical Centre, Johannesburg, South AfricaDepartment of Paediatrics and Child Health, Charlotte Maxeke Johannesburg Academic Hospital and Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South AfricaDivision of Maternal Critical Care, Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, Texas, USA; Department of Obstetrics and Gynaecology, Charlotte Maxeke Johannesburg Academic Hospital and Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South AfricaDepartment of Obstetrics and Gynaecology, Tygerberg Hospital and Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South AfricaDepartment of Obstetrics and Gynaecology, Charlotte Maxeke Johannesburg Academic Hospital and Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South AfricaDepartment of Gastroenterology and Hepatology, Wits Donald Gordon Medical Centre, Johannesburg, South Africa; Division of Medical Gastroenterology, Department of Internal Medicine, Charlotte Maxeke Johannesburg Academic Hospital and Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South AfricaDivision of Medical Gastroenterology, Department of Internal Medicine, Charlotte Maxeke Johannesburg Academic Hospital and Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South AfricaDivision of Medical Gastroenterology, Department of Internal Medicine, Charlotte Maxeke Johannesburg Academic Hospital and Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South AfricaDivision of Medical Gastroenterology, Department of Internal Medicine, Charlotte Maxeke Johannesburg Academic Hospital and Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South AfricaPrivate Practice, Netcare Park Lane Hospital, Johannesburg, South AfricaDivision of Nephrology, Department of Internal Medicine, Charlotte Maxeke Johannesburg Academic Hospital and Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South AfricaDepartment of Obstetrics and Gynaecology, Charlotte Maxeke Johannesburg Academic Hospital and Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South AfricaDepartment of Obstetrics and Gynaecology, Charlotte Maxeke Johannesburg Academic Hospital and Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South AfricaDivision of Nephrology, Department of Internal Medicine, Charlotte Maxeke Johannesburg Academic Hospital and Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South AfricaWomen’s Services, King’s College Hospital, London, UKObstetric Internal Medicine Unit, Department of Internal Medicine, Charlotte Maxeke Johannesburg Academic Hospital and Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa Pregnancy in kidney and liver transplant recipients presents unique challenges and risks for both maternal and fetal health. This article examines the management of pregnancy in kidney and liver transplant recipients, focusing on pre-pregnancy counselling, trimester-specific care, the teratogenic effects of immunosuppressive drugs, and the role of the multidisciplinary team. While South African (SA) data on this topic are limited, the Transplant Pregnancy Registry International has provided valuable insights. Despite the increased risk of maternal and fetal complications, the overall risk of graft loss during pregnancy is low. Graft survival rates are comparable between pregnant and non- pregnant transplant recipients, except for pregnancies occurring within 1 year of transplantation. By addressing the complexities of managing pregnant women with kidney or liver transplants, this article underscores the importance of tailored care and the involvement of various medical specialists. It also explores the safety of and potential complications associated with specific immunosuppressive therapies during pregnancy. Further research is needed to enhance our understanding and optimise the management of these high-risk pregnancies in SA. https://samajournals.co.za/index.php/samj/article/view/1240Pregnancyliver transplantkidney transplanthigh-risk obstetrics |
| spellingShingle | A Wise N E Diana B Bobat R T Saggers S Bhoora S Budhram L Chauke V G Lala A Mahomed D Mokgoko M Seabi B Moore S Naidoo R B Nyakoe N Odell G Paget L Wium J Zamparini Pregnancy after kidney and liver transplantation South African Medical Journal Pregnancy liver transplant kidney transplant high-risk obstetrics |
| title | Pregnancy after kidney and liver transplantation |
| title_full | Pregnancy after kidney and liver transplantation |
| title_fullStr | Pregnancy after kidney and liver transplantation |
| title_full_unstemmed | Pregnancy after kidney and liver transplantation |
| title_short | Pregnancy after kidney and liver transplantation |
| title_sort | pregnancy after kidney and liver transplantation |
| topic | Pregnancy liver transplant kidney transplant high-risk obstetrics |
| url | https://samajournals.co.za/index.php/samj/article/view/1240 |
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