The protective role of GLP-1 in neuro-ophthalmology
Despite recent advancements in the field of neuro-ophthalmology, the rising rates of neurological and ophthalmological conditions, mismatches between supply and demand of clinicians, and an aging population underscore the urgent need to explore new therapeutic approaches within the field. Glucagon-l...
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| Language: | English |
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Open Exploration
2023-08-01
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| Series: | Exploration of Drug Science |
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| Online Access: | https://www.explorationpub.com/uploads/Article/A100815/100815.pdf |
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| author | Sohum Sheth Aashay Patel Marco Foreman Mohammed Mumtaz Akshay Reddy Ramy Sharaf Siddharth Sheth Brandon Lucke-Wold |
| author_facet | Sohum Sheth Aashay Patel Marco Foreman Mohammed Mumtaz Akshay Reddy Ramy Sharaf Siddharth Sheth Brandon Lucke-Wold |
| author_sort | Sohum Sheth |
| collection | DOAJ |
| description | Despite recent advancements in the field of neuro-ophthalmology, the rising rates of neurological and ophthalmological conditions, mismatches between supply and demand of clinicians, and an aging population underscore the urgent need to explore new therapeutic approaches within the field. Glucagon-like peptide 1 receptor agonists (GLP-1RAs), traditionally used in the treatment of type 2 diabetes, are becoming increasingly appreciated for their diverse applications. Recently, GLP-1RAs have been approved for the treatment of obesity and recognized for their cardioprotective effects. Emerging evidence indicates some GLP-1RAs can cross the blood-brain barrier and may have neuroprotective effects. Therefore, this article aims to review the literature on the neurologic and neuro-ophthalmic role of glucagon-like peptide 1 (GLP-1). This article describes GLP-1 peptide characteristics and the mechanisms mediating its known role in increasing insulin, decreasing glucagon, delaying gastric emptying, and promoting satiety. This article identifies the sources and targets of GLP-1 in the brain and review the mechanisms which mediate its neuroprotective effects, as well as implications for Alzheimer’s disease (AD) and Parkinson’s disease (PD). Furthermore, the preclinical works which unravel the effects of GLP-1 in ocular dynamics and the preclinical literature regarding GLP-1RA use in the management of several neuro-ophthalmic conditions, including diabetic retinopathy (DR), glaucoma, and idiopathic intracranial hypertension (IIH) are discussed. |
| format | Article |
| id | doaj-art-34ec04b972624801929cc6112cbce4ed |
| institution | Kabale University |
| issn | 2836-7677 |
| language | English |
| publishDate | 2023-08-01 |
| publisher | Open Exploration |
| record_format | Article |
| series | Exploration of Drug Science |
| spelling | doaj-art-34ec04b972624801929cc6112cbce4ed2025-02-08T05:16:47ZengOpen ExplorationExploration of Drug Science2836-76772023-08-011422123810.37349/eds.2023.00015The protective role of GLP-1 in neuro-ophthalmologySohum Sheth0https://orcid.org/0000-0002-1138-6135Aashay Patel1https://orcid.org/0000-0003-3301-8066Marco Foreman2https://orcid.org/0000-0002-5551-7061Mohammed Mumtaz3https://orcid.org/0000-0002-7333-9756Akshay Reddy4https://orcid.org/0000-0001-9000-9890Ramy Sharaf5https://orcid.org/0000-0001-9942-3852Siddharth Sheth6https://orcid.org/0009-0009-1076-6951Brandon Lucke-Wold7https://orcid.org/0000-0001-6577-4080College of Medicine, University of Florida, Gainesville, FL 32608, USACollege of Medicine, University of Florida, Gainesville, FL 32608, USACollege of Medicine, University of Florida, Gainesville, FL 32608, USACollege of Medicine, University of Florida, Gainesville, FL 32608, USACollege of Medicine, University of Florida, Gainesville, FL 32608, USACollege of Medicine, University of Florida, Gainesville, FL 32608, USACollege of Medicine, University of Florida, Gainesville, FL 32608, USADepartment of Neurosurgery, University of Florida, Gainesville, FL 32608, USADespite recent advancements in the field of neuro-ophthalmology, the rising rates of neurological and ophthalmological conditions, mismatches between supply and demand of clinicians, and an aging population underscore the urgent need to explore new therapeutic approaches within the field. Glucagon-like peptide 1 receptor agonists (GLP-1RAs), traditionally used in the treatment of type 2 diabetes, are becoming increasingly appreciated for their diverse applications. Recently, GLP-1RAs have been approved for the treatment of obesity and recognized for their cardioprotective effects. Emerging evidence indicates some GLP-1RAs can cross the blood-brain barrier and may have neuroprotective effects. Therefore, this article aims to review the literature on the neurologic and neuro-ophthalmic role of glucagon-like peptide 1 (GLP-1). This article describes GLP-1 peptide characteristics and the mechanisms mediating its known role in increasing insulin, decreasing glucagon, delaying gastric emptying, and promoting satiety. This article identifies the sources and targets of GLP-1 in the brain and review the mechanisms which mediate its neuroprotective effects, as well as implications for Alzheimer’s disease (AD) and Parkinson’s disease (PD). Furthermore, the preclinical works which unravel the effects of GLP-1 in ocular dynamics and the preclinical literature regarding GLP-1RA use in the management of several neuro-ophthalmic conditions, including diabetic retinopathy (DR), glaucoma, and idiopathic intracranial hypertension (IIH) are discussed.https://www.explorationpub.com/uploads/Article/A100815/100815.pdfglucagon-like peptide 1incretinsneuro-ophthalmologyneuroprotection |
| spellingShingle | Sohum Sheth Aashay Patel Marco Foreman Mohammed Mumtaz Akshay Reddy Ramy Sharaf Siddharth Sheth Brandon Lucke-Wold The protective role of GLP-1 in neuro-ophthalmology Exploration of Drug Science glucagon-like peptide 1 incretins neuro-ophthalmology neuroprotection |
| title | The protective role of GLP-1 in neuro-ophthalmology |
| title_full | The protective role of GLP-1 in neuro-ophthalmology |
| title_fullStr | The protective role of GLP-1 in neuro-ophthalmology |
| title_full_unstemmed | The protective role of GLP-1 in neuro-ophthalmology |
| title_short | The protective role of GLP-1 in neuro-ophthalmology |
| title_sort | protective role of glp 1 in neuro ophthalmology |
| topic | glucagon-like peptide 1 incretins neuro-ophthalmology neuroprotection |
| url | https://www.explorationpub.com/uploads/Article/A100815/100815.pdf |
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