Mycophenolate Mofetil and Clostridium difficile-associated Colitis
Aim. A clinical observation of colitis conditioned by mycophenolate mofetil intake and concomitant Clostridium difficile-associated disease.Key points. Mycophenolate mofetil (MMF) is an active immunosuppressant with side effects affecting gastrointestinal tract (GIT). A 37-yo male patient with type...
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Gastro LLC
2021-12-01
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| Series: | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
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| Online Access: | https://www.gastro-j.ru/jour/article/view/639 |
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| author | A. I. Dolgushina A. A. Selyanina E. A. Mezenceva A. G. Vasilenko L. I. Pozdeeva L. Yu. Zhuravleva E. R. Olevskaya E. A. Fedorova |
| author_facet | A. I. Dolgushina A. A. Selyanina E. A. Mezenceva A. G. Vasilenko L. I. Pozdeeva L. Yu. Zhuravleva E. R. Olevskaya E. A. Fedorova |
| author_sort | A. I. Dolgushina |
| collection | DOAJ |
| description | Aim. A clinical observation of colitis conditioned by mycophenolate mofetil intake and concomitant Clostridium difficile-associated disease.Key points. Mycophenolate mofetil (MMF) is an active immunosuppressant with side effects affecting gastrointestinal tract (GIT). A 37-yo male patient with type 1 diabetes mellitus was admitted at a gastroenterology unit with clinical signs of diarrhoea with haematochezia. A history of diabetic nephropathy and related-donor pre-dialysis kidney transplantation in 2012, since when MMF intake was 2000 mg daily. Catarrhal ulcerative colitis in colonoscopy, C. difficile toxins in pathogen stool panel. Ulcerative, ischaemic colitises and the graft-versus-host disease were ruled out in examination. A positive clinical and endoscopic trend was observed upon MMF withdrawn and start of vancomycin.Conclusion. The case presented illustrates the clinical picture and diagnostic algorithm in MMF-associated colitis. The case-distinctive is association with C. difficile infection. |
| format | Article |
| id | doaj-art-35dc3e2da2ea4652bf08d31bad00b5e0 |
| institution | Kabale University |
| issn | 1382-4376 2658-6673 |
| language | Russian |
| publishDate | 2021-12-01 |
| publisher | Gastro LLC |
| record_format | Article |
| series | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
| spelling | doaj-art-35dc3e2da2ea4652bf08d31bad00b5e02025-02-10T16:14:37ZrusGastro LLCРоссийский журнал гастроэнтерологии, гепатологии, колопроктологии1382-43762658-66732021-12-01314646910.22416/1382-4376-2021-31-4-64-69439Mycophenolate Mofetil and Clostridium difficile-associated ColitisA. I. Dolgushina0A. A. Selyanina1E. A. Mezenceva2A. G. Vasilenko3L. I. Pozdeeva4L. Yu. Zhuravleva5E. R. Olevskaya6E. A. Fedorova7South Ural State Medical UniversitySouth Ural State Medical UniversitySouth Ural State Medical UniversityChelyabinsk Regional Clinical HospitalChelyabinsk Regional Clinical HospitalChelyabinsk Regional Clinical HospitalSouth Ural State Medical University; Chelyabinsk Regional Clinical HospitalChelyabinsk Regional Clinical HospitalAim. A clinical observation of colitis conditioned by mycophenolate mofetil intake and concomitant Clostridium difficile-associated disease.Key points. Mycophenolate mofetil (MMF) is an active immunosuppressant with side effects affecting gastrointestinal tract (GIT). A 37-yo male patient with type 1 diabetes mellitus was admitted at a gastroenterology unit with clinical signs of diarrhoea with haematochezia. A history of diabetic nephropathy and related-donor pre-dialysis kidney transplantation in 2012, since when MMF intake was 2000 mg daily. Catarrhal ulcerative colitis in colonoscopy, C. difficile toxins in pathogen stool panel. Ulcerative, ischaemic colitises and the graft-versus-host disease were ruled out in examination. A positive clinical and endoscopic trend was observed upon MMF withdrawn and start of vancomycin.Conclusion. The case presented illustrates the clinical picture and diagnostic algorithm in MMF-associated colitis. The case-distinctive is association with C. difficile infection.https://www.gastro-j.ru/jour/article/view/639mycophenolate mofetil-associated colitismycophenolate mofetilclostridium difficilec. difficile-associated diseasediarrhoeahaematochezia |
| spellingShingle | A. I. Dolgushina A. A. Selyanina E. A. Mezenceva A. G. Vasilenko L. I. Pozdeeva L. Yu. Zhuravleva E. R. Olevskaya E. A. Fedorova Mycophenolate Mofetil and Clostridium difficile-associated Colitis Российский журнал гастроэнтерологии, гепатологии, колопроктологии mycophenolate mofetil-associated colitis mycophenolate mofetil clostridium difficile c. difficile-associated disease diarrhoea haematochezia |
| title | Mycophenolate Mofetil and Clostridium difficile-associated Colitis |
| title_full | Mycophenolate Mofetil and Clostridium difficile-associated Colitis |
| title_fullStr | Mycophenolate Mofetil and Clostridium difficile-associated Colitis |
| title_full_unstemmed | Mycophenolate Mofetil and Clostridium difficile-associated Colitis |
| title_short | Mycophenolate Mofetil and Clostridium difficile-associated Colitis |
| title_sort | mycophenolate mofetil and clostridium difficile associated colitis |
| topic | mycophenolate mofetil-associated colitis mycophenolate mofetil clostridium difficile c. difficile-associated disease diarrhoea haematochezia |
| url | https://www.gastro-j.ru/jour/article/view/639 |
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