Correlation between uric acid levels and bone mineral density in patients with type 2 diabetes mellitus: a systematic review and meta-analysis
PurposeTo explore the controversial relationship between uric acid (UA) levels and bone mineral density (BMD) in patients with type 2 diabetes mellitus (T2DM).Patients and methodsThe PubMed, Embase, and Cochrane Library databases were searched using keywords and related words. Study quality was eval...
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| Format: | Article |
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2025.1415550/full |
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| author | Hang Zhao Cuijuan Qi Yunjia Zhang Luping Ren Shuchun Chen |
| author_facet | Hang Zhao Cuijuan Qi Yunjia Zhang Luping Ren Shuchun Chen |
| author_sort | Hang Zhao |
| collection | DOAJ |
| description | PurposeTo explore the controversial relationship between uric acid (UA) levels and bone mineral density (BMD) in patients with type 2 diabetes mellitus (T2DM).Patients and methodsThe PubMed, Embase, and Cochrane Library databases were searched using keywords and related words. Study quality was evaluated using the Newcastle-Ottawa Scale. Studies retrieved in the literature search were systematically screened to extract information and data based on predefined inclusion and exclusion criteria. RevMan version 5.3 and Stata Release 13.0 were used for statistical analysis. Results are expressed as mean difference (MD) and corresponding 95% confidence interval (CI). Heterogeneity was evaluated using the I2 and Q tests.ResultsThis meta-analysis included 10 studies comprising 5,717 patients with T2DM. Study quality ranged from moderate to high. Results of comparative analyses were as follows: normal BMD versus (vs.) osteoporosis (OP) in females, MD −13.83 μmol/L (95% CI −41.69 to 14.03); I2 = 7%; P=0.30); normal BMD vs. osteopenia in females, MD −12.41 μmol/L (95% CI −37.81 to 12.99; I2 = 0%; P=0.92); normal BMD vs. abnormal BMD (osteopenia/OP), MD −23.82 μmol/L (95% CI −33.50 to −14.13; I2 = 0%; P=0.44); and osteopenia vs. OP, MD −22.35 μmol/L (95% CI −29.55 to −15.15; I2 = 5%; P=0.39). No publication bias was observed.ConclusionCompared with normal BMD, abnormal BMD (osteopenia/OP) was associated with lower UA levels. Compared with osteopenia, OP also showed lower UA.Systematic review registration: |
| format | Article |
| id | doaj-art-35f7bf37eccf47bdb62af8d4d5d54f7b |
| institution | Kabale University |
| issn | 1664-2392 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj-art-35f7bf37eccf47bdb62af8d4d5d54f7b2025-02-07T05:10:34ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922025-02-011610.3389/fendo.2025.14155501415550Correlation between uric acid levels and bone mineral density in patients with type 2 diabetes mellitus: a systematic review and meta-analysisHang ZhaoCuijuan QiYunjia ZhangLuping RenShuchun ChenPurposeTo explore the controversial relationship between uric acid (UA) levels and bone mineral density (BMD) in patients with type 2 diabetes mellitus (T2DM).Patients and methodsThe PubMed, Embase, and Cochrane Library databases were searched using keywords and related words. Study quality was evaluated using the Newcastle-Ottawa Scale. Studies retrieved in the literature search were systematically screened to extract information and data based on predefined inclusion and exclusion criteria. RevMan version 5.3 and Stata Release 13.0 were used for statistical analysis. Results are expressed as mean difference (MD) and corresponding 95% confidence interval (CI). Heterogeneity was evaluated using the I2 and Q tests.ResultsThis meta-analysis included 10 studies comprising 5,717 patients with T2DM. Study quality ranged from moderate to high. Results of comparative analyses were as follows: normal BMD versus (vs.) osteoporosis (OP) in females, MD −13.83 μmol/L (95% CI −41.69 to 14.03); I2 = 7%; P=0.30); normal BMD vs. osteopenia in females, MD −12.41 μmol/L (95% CI −37.81 to 12.99; I2 = 0%; P=0.92); normal BMD vs. abnormal BMD (osteopenia/OP), MD −23.82 μmol/L (95% CI −33.50 to −14.13; I2 = 0%; P=0.44); and osteopenia vs. OP, MD −22.35 μmol/L (95% CI −29.55 to −15.15; I2 = 5%; P=0.39). No publication bias was observed.ConclusionCompared with normal BMD, abnormal BMD (osteopenia/OP) was associated with lower UA levels. Compared with osteopenia, OP also showed lower UA.Systematic review registration:https://www.frontiersin.org/articles/10.3389/fendo.2025.1415550/fulltype 2 diabetesbone mineral densityosteoporosisuric acidbone metabolism |
| spellingShingle | Hang Zhao Cuijuan Qi Yunjia Zhang Luping Ren Shuchun Chen Correlation between uric acid levels and bone mineral density in patients with type 2 diabetes mellitus: a systematic review and meta-analysis Frontiers in Endocrinology type 2 diabetes bone mineral density osteoporosis uric acid bone metabolism |
| title | Correlation between uric acid levels and bone mineral density in patients with type 2 diabetes mellitus: a systematic review and meta-analysis |
| title_full | Correlation between uric acid levels and bone mineral density in patients with type 2 diabetes mellitus: a systematic review and meta-analysis |
| title_fullStr | Correlation between uric acid levels and bone mineral density in patients with type 2 diabetes mellitus: a systematic review and meta-analysis |
| title_full_unstemmed | Correlation between uric acid levels and bone mineral density in patients with type 2 diabetes mellitus: a systematic review and meta-analysis |
| title_short | Correlation between uric acid levels and bone mineral density in patients with type 2 diabetes mellitus: a systematic review and meta-analysis |
| title_sort | correlation between uric acid levels and bone mineral density in patients with type 2 diabetes mellitus a systematic review and meta analysis |
| topic | type 2 diabetes bone mineral density osteoporosis uric acid bone metabolism |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2025.1415550/full |
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