A one-two punch of inflammation and oxidative stress promotes revascularization for diabetic foot ulcers
Patients with diabetic foot ulcers (DFU) suffering from severe lower limb ischemia face the risk of amputation. Concomitant oxidative stress and hyperinflammation commonly manifest within the tissue affected by DFU, exacerbating the deterioration of DFU wounds. One-two punch strategy of anti-oxidati...
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Elsevier
2025-04-01
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| Series: | Materials Today Bio |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590006425001061 |
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| author | Li Chen Yunrong Li Xuanxuan Zhang Lixin Ma Cheng Zhang Huanhuan Chen |
| author_facet | Li Chen Yunrong Li Xuanxuan Zhang Lixin Ma Cheng Zhang Huanhuan Chen |
| author_sort | Li Chen |
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| description | Patients with diabetic foot ulcers (DFU) suffering from severe lower limb ischemia face the risk of amputation. Concomitant oxidative stress and hyperinflammation commonly manifest within the tissue affected by DFU, exacerbating the deterioration of DFU wounds. One-two punch strategy of anti-oxidative damage plus anti-inflammatory is anticipated to tackle the challenge of non-healing diabetic wounds. Here, we introduced a dual-approach treatment strategy involving the probiotic Weissella cibaria (WC) modified with desferrioxamine (DFO). This engineered probiotic, known as WC@DPA, aims to ameliorate oxidative stress within the ischemic microenvironment and stimulate the formation and proliferation of endothelial tubular structures. When applied with chronic wounds and ischemic hindlimb injuries in diabetic mice, WC@DPA gel demonstrated an effective performance in modulating oxidative damage, reducing local vascular inflammation, and facilitating muscle tissue repair and vascular reconstruction. We believe that our engineered probiotic represents a promising therapeutic avenue for managing ischemic injuries associated with DFU. |
| format | Article |
| id | doaj-art-364813441e2f4f00b7f9fe29072b6126 |
| institution | Kabale University |
| issn | 2590-0064 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials Today Bio |
| spelling | doaj-art-364813441e2f4f00b7f9fe29072b61262025-02-07T04:48:10ZengElsevierMaterials Today Bio2590-00642025-04-0131101548A one-two punch of inflammation and oxidative stress promotes revascularization for diabetic foot ulcersLi Chen0Yunrong Li1Xuanxuan Zhang2Lixin Ma3Cheng Zhang4Huanhuan Chen5State Key Laboratory of Biocatalysis and Enzyme Engineering, Hubei Key Laboratory of Industrial Biotechnology, School of Life Sciences, Hubei University, Wuhan, 430062, PR ChinaGuangxi International Zhuang Medicine Hospital Affiliated to Guangxi University of Chinese Medicine, Guangxi, 530201, PR ChinaState Key Laboratory of Biocatalysis and Enzyme Engineering, Hubei Key Laboratory of Industrial Biotechnology, School of Life Sciences, Hubei University, Wuhan, 430062, PR ChinaState Key Laboratory of Biocatalysis and Enzyme Engineering, Hubei Key Laboratory of Industrial Biotechnology, School of Life Sciences, Hubei University, Wuhan, 430062, PR China; Corresponding author.State Key Laboratory of Biocatalysis and Enzyme Engineering, Hubei Key Laboratory of Industrial Biotechnology, School of Life Sciences, Hubei University, Wuhan, 430062, PR China; Corresponding author.State Key Laboratory of Biocatalysis and Enzyme Engineering, Hubei Key Laboratory of Industrial Biotechnology, School of Life Sciences, Hubei University, Wuhan, 430062, PR China; Corresponding author.Patients with diabetic foot ulcers (DFU) suffering from severe lower limb ischemia face the risk of amputation. Concomitant oxidative stress and hyperinflammation commonly manifest within the tissue affected by DFU, exacerbating the deterioration of DFU wounds. One-two punch strategy of anti-oxidative damage plus anti-inflammatory is anticipated to tackle the challenge of non-healing diabetic wounds. Here, we introduced a dual-approach treatment strategy involving the probiotic Weissella cibaria (WC) modified with desferrioxamine (DFO). This engineered probiotic, known as WC@DPA, aims to ameliorate oxidative stress within the ischemic microenvironment and stimulate the formation and proliferation of endothelial tubular structures. When applied with chronic wounds and ischemic hindlimb injuries in diabetic mice, WC@DPA gel demonstrated an effective performance in modulating oxidative damage, reducing local vascular inflammation, and facilitating muscle tissue repair and vascular reconstruction. We believe that our engineered probiotic represents a promising therapeutic avenue for managing ischemic injuries associated with DFU.http://www.sciencedirect.com/science/article/pii/S2590006425001061Engineered living materialsNitric oxideWound healingAngiogenesisAnti-inflammation |
| spellingShingle | Li Chen Yunrong Li Xuanxuan Zhang Lixin Ma Cheng Zhang Huanhuan Chen A one-two punch of inflammation and oxidative stress promotes revascularization for diabetic foot ulcers Materials Today Bio Engineered living materials Nitric oxide Wound healing Angiogenesis Anti-inflammation |
| title | A one-two punch of inflammation and oxidative stress promotes revascularization for diabetic foot ulcers |
| title_full | A one-two punch of inflammation and oxidative stress promotes revascularization for diabetic foot ulcers |
| title_fullStr | A one-two punch of inflammation and oxidative stress promotes revascularization for diabetic foot ulcers |
| title_full_unstemmed | A one-two punch of inflammation and oxidative stress promotes revascularization for diabetic foot ulcers |
| title_short | A one-two punch of inflammation and oxidative stress promotes revascularization for diabetic foot ulcers |
| title_sort | one two punch of inflammation and oxidative stress promotes revascularization for diabetic foot ulcers |
| topic | Engineered living materials Nitric oxide Wound healing Angiogenesis Anti-inflammation |
| url | http://www.sciencedirect.com/science/article/pii/S2590006425001061 |
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