Neuroimmunology of psoriasis: Possible roles for calcitonin gene-related peptide in its pathogenesis
The nervous system has a complex interplay with the immune system, especially at barrier sites such as the skin. This allows it to play a role in a variety of cutaneous inflammatory disorders such as psoriasis, exerting effects on various immune cells via effector molecules such as neuropeptides. In...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-03-01
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| Series: | Brain, Behavior, & Immunity - Health |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S266635462500016X |
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| _version_ | 1825199403409866752 |
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| author | Joshua Kotlyar Richard D. Granstein |
| author_facet | Joshua Kotlyar Richard D. Granstein |
| author_sort | Joshua Kotlyar |
| collection | DOAJ |
| description | The nervous system has a complex interplay with the immune system, especially at barrier sites such as the skin. This allows it to play a role in a variety of cutaneous inflammatory disorders such as psoriasis, exerting effects on various immune cells via effector molecules such as neuropeptides. In this review, we discuss the role of calcitonin gene-related peptide in modulating the immune system and inflammation, with a focus on psoriasis. |
| format | Article |
| id | doaj-art-37aee791157348199564da046956713d |
| institution | Kabale University |
| issn | 2666-3546 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brain, Behavior, & Immunity - Health |
| spelling | doaj-art-37aee791157348199564da046956713d2025-02-08T05:01:17ZengElsevierBrain, Behavior, & Immunity - Health2666-35462025-03-0144100958Neuroimmunology of psoriasis: Possible roles for calcitonin gene-related peptide in its pathogenesisJoshua Kotlyar0Richard D. Granstein1Israel Englander Department of Dermatology, Weill Cornell Medicine, 1305 York Avenue, WGC9, New York, NY, 10021, USA; SUNY Downstate Health Sciences University College of Medicine, 450 Clarkson Avenue, Brooklyn, NY, 11203, USAIsrael Englander Department of Dermatology, Weill Cornell Medicine, 1305 York Avenue, WGC9, New York, NY, 10021, USA; Corresponding author.The nervous system has a complex interplay with the immune system, especially at barrier sites such as the skin. This allows it to play a role in a variety of cutaneous inflammatory disorders such as psoriasis, exerting effects on various immune cells via effector molecules such as neuropeptides. In this review, we discuss the role of calcitonin gene-related peptide in modulating the immune system and inflammation, with a focus on psoriasis.http://www.sciencedirect.com/science/article/pii/S266635462500016XNeurogenic inflammationCalcitonin gene-related peptideDendritic cellsNociceptorsSkin immunityPsoriasis |
| spellingShingle | Joshua Kotlyar Richard D. Granstein Neuroimmunology of psoriasis: Possible roles for calcitonin gene-related peptide in its pathogenesis Brain, Behavior, & Immunity - Health Neurogenic inflammation Calcitonin gene-related peptide Dendritic cells Nociceptors Skin immunity Psoriasis |
| title | Neuroimmunology of psoriasis: Possible roles for calcitonin gene-related peptide in its pathogenesis |
| title_full | Neuroimmunology of psoriasis: Possible roles for calcitonin gene-related peptide in its pathogenesis |
| title_fullStr | Neuroimmunology of psoriasis: Possible roles for calcitonin gene-related peptide in its pathogenesis |
| title_full_unstemmed | Neuroimmunology of psoriasis: Possible roles for calcitonin gene-related peptide in its pathogenesis |
| title_short | Neuroimmunology of psoriasis: Possible roles for calcitonin gene-related peptide in its pathogenesis |
| title_sort | neuroimmunology of psoriasis possible roles for calcitonin gene related peptide in its pathogenesis |
| topic | Neurogenic inflammation Calcitonin gene-related peptide Dendritic cells Nociceptors Skin immunity Psoriasis |
| url | http://www.sciencedirect.com/science/article/pii/S266635462500016X |
| work_keys_str_mv | AT joshuakotlyar neuroimmunologyofpsoriasispossiblerolesforcalcitoningenerelatedpeptideinitspathogenesis AT richarddgranstein neuroimmunologyofpsoriasispossiblerolesforcalcitoningenerelatedpeptideinitspathogenesis |