The Relationship Between First-Trimester Aneuploidy Markers and Birth Weight
OBJECTIVE: We aimed to determine the relationship between the first-trimester aneuploidy screeningma and the predicted weight at birth: Small for gestational age and large for gestational age. STUDY DESIGN: 594 low-risk pregnant women with a singleton pregnancy, who underwent first-trimester ane...
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| Format: | Article |
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Medical Network
2021-12-01
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| Series: | Gynecology Obstetrics & Reproductive Medicine |
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| Online Access: | https://gorm.com.tr/index.php/GORM/article/view/1215 |
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| author | Cenk Soysal Hatice Sari Ozlem Erten Ismail Biyik Onur Ince Yasemin Tasci Nadi Keskin |
| author_facet | Cenk Soysal Hatice Sari Ozlem Erten Ismail Biyik Onur Ince Yasemin Tasci Nadi Keskin |
| author_sort | Cenk Soysal |
| collection | DOAJ |
| description |
OBJECTIVE: We aimed to determine the relationship between the first-trimester aneuploidy screeningma and the predicted weight at birth: Small for gestational age and large for gestational age.
STUDY DESIGN: 594 low-risk pregnant women with a singleton pregnancy, who underwent first-trimester aneuploidy screening by measuring nuchal translucency, maternal serum free beta-human chorionic gonadotropin, and pregnancy-associated plasma protein-A were included in the study. Those weighing above the 3rd percentile and below the 10th percentile were defined as small for gestational age, and those over the 90th percentile were defined as large for gestational age.
RESULTS: A total of 594 pregnant women were enrolled. The mean maternal age of the studied group was 28.8±5.5 years. Low maternal serum pregnancy-associated plasma protein-A levels and decreased nuchal translucency measurements were associated with the small for gestational age newborn (p<0.001 and p=0.001, respectively). There is a significant correlation with large for gestational age for newborns only with an increase in maternal serum pregnancy-associated plasma protein-A levels (p=0.001). beta-human chorionic gonadotropin levels were not associated with the birth weight (p=0.735).
CONCLUSION: Maternal serum pregnancy-associated plasma protein-A levels, one of the markers in first-trimester aneuploidy screening, can be used in the prediction of small for gestational age and large for gestational age However, due to its low correlation, it is not a suitable screening test for clinical practice.
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| format | Article |
| id | doaj-art-380b44d7fc1c445aa0b67ff77a643d66 |
| institution | Kabale University |
| issn | 1300-4751 2602-4918 |
| language | English |
| publishDate | 2021-12-01 |
| publisher | Medical Network |
| record_format | Article |
| series | Gynecology Obstetrics & Reproductive Medicine |
| spelling | doaj-art-380b44d7fc1c445aa0b67ff77a643d662025-02-11T21:13:43ZengMedical NetworkGynecology Obstetrics & Reproductive Medicine1300-47512602-49182021-12-0127310.21613/GORM.2021.1215The Relationship Between First-Trimester Aneuploidy Markers and Birth WeightCenk Soysal0Hatice Sari1Ozlem Erten2Ismail Biyik3Onur Ince4Yasemin Tasci5Nadi Keskin6Kütahya Health Sciences UniversityKütahya Health Sciences UniversityKütahya Health Sciences UniversityKütahya Health Sciences UniversityKütahya Health Sciences UniversityKütahya Health Sciences UniversityKütahya Health Sciences University OBJECTIVE: We aimed to determine the relationship between the first-trimester aneuploidy screeningma and the predicted weight at birth: Small for gestational age and large for gestational age. STUDY DESIGN: 594 low-risk pregnant women with a singleton pregnancy, who underwent first-trimester aneuploidy screening by measuring nuchal translucency, maternal serum free beta-human chorionic gonadotropin, and pregnancy-associated plasma protein-A were included in the study. Those weighing above the 3rd percentile and below the 10th percentile were defined as small for gestational age, and those over the 90th percentile were defined as large for gestational age. RESULTS: A total of 594 pregnant women were enrolled. The mean maternal age of the studied group was 28.8±5.5 years. Low maternal serum pregnancy-associated plasma protein-A levels and decreased nuchal translucency measurements were associated with the small for gestational age newborn (p<0.001 and p=0.001, respectively). There is a significant correlation with large for gestational age for newborns only with an increase in maternal serum pregnancy-associated plasma protein-A levels (p=0.001). beta-human chorionic gonadotropin levels were not associated with the birth weight (p=0.735). CONCLUSION: Maternal serum pregnancy-associated plasma protein-A levels, one of the markers in first-trimester aneuploidy screening, can be used in the prediction of small for gestational age and large for gestational age However, due to its low correlation, it is not a suitable screening test for clinical practice. https://gorm.com.tr/index.php/GORM/article/view/1215Birth WeightFree Beta-Human Chorionic GonadotropinLarge for gestational ageNuchal translucencyPregnancy-Associated Plasma Protein-ASmall for gestational age |
| spellingShingle | Cenk Soysal Hatice Sari Ozlem Erten Ismail Biyik Onur Ince Yasemin Tasci Nadi Keskin The Relationship Between First-Trimester Aneuploidy Markers and Birth Weight Gynecology Obstetrics & Reproductive Medicine Birth Weight Free Beta-Human Chorionic Gonadotropin Large for gestational age Nuchal translucency Pregnancy-Associated Plasma Protein-A Small for gestational age |
| title | The Relationship Between First-Trimester Aneuploidy Markers and Birth Weight |
| title_full | The Relationship Between First-Trimester Aneuploidy Markers and Birth Weight |
| title_fullStr | The Relationship Between First-Trimester Aneuploidy Markers and Birth Weight |
| title_full_unstemmed | The Relationship Between First-Trimester Aneuploidy Markers and Birth Weight |
| title_short | The Relationship Between First-Trimester Aneuploidy Markers and Birth Weight |
| title_sort | relationship between first trimester aneuploidy markers and birth weight |
| topic | Birth Weight Free Beta-Human Chorionic Gonadotropin Large for gestational age Nuchal translucency Pregnancy-Associated Plasma Protein-A Small for gestational age |
| url | https://gorm.com.tr/index.php/GORM/article/view/1215 |
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