Advanced glycation end products and risk of mortality in patients with cirrhosis: a prospective cohort study
Abstract The role of diet in reducing the burden of liver disease and mortality attributed to cirrhosis is very imperative. The present study scrutinized the relationship between dietary advanced glycation end products (AGEs) and mortality in patients with cirrhosis. This research was a prospective...
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Nature Portfolio
2025-02-01
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| Online Access: | https://doi.org/10.1038/s41598-025-89433-y |
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| author | Mohsen Shaygan Tabar Maryam Nilghaz Azita Hekmatdoost Fereshteh Pashayee-Khamene Zeinab Mokhtari Sara Karimi Saleheh Ahmadzadeh Mehdi Saberifiroozi Behzad Hatami Zahra Yari |
| author_facet | Mohsen Shaygan Tabar Maryam Nilghaz Azita Hekmatdoost Fereshteh Pashayee-Khamene Zeinab Mokhtari Sara Karimi Saleheh Ahmadzadeh Mehdi Saberifiroozi Behzad Hatami Zahra Yari |
| author_sort | Mohsen Shaygan Tabar |
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| description | Abstract The role of diet in reducing the burden of liver disease and mortality attributed to cirrhosis is very imperative. The present study scrutinized the relationship between dietary advanced glycation end products (AGEs) and mortality in patients with cirrhosis. This research was a prospective cohort study on 166 ambulatory cirrhotic patients who had been diagnosed with cirrhosis for a maximum of six months. Follow-up of patients continued for 5 years until May 2024. To determine the incidence of mortality in the quartiles of dietary AGEs, cox regression models were used with the adjustment of potential confounding variables. Although the first model of the analysis by adjusting the results for age and sex failed to show a significant increase in the risk of mortality in patients (HRQ4 vs. Q1 = 2.64; 95% CI = 0.9–7.5, P trend = 0.075), after adjusting the results for further confounders in the second (HRQ4 vs. Q1 = 3.56; 95% CI = 1.1–11.6, P trend = 0.040) and third (HRQ4 vs. Q1 = 3.3; 95% CI = 1.79–13.7, P trend = 0.048) models, the P trend for the risk of mortality during the quartiles of AGEs became significant. In addition, along with increasing trend of dietary AGEs, the number of deaths increased significantly (P = 0.024). Higher mortality risk was generally attributed to higher dietary AGEs in patients with cirrhosis. |
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| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj-art-384b592c67eb43fa875838ba697277872025-02-09T12:34:08ZengNature PortfolioScientific Reports2045-23222025-02-011511810.1038/s41598-025-89433-yAdvanced glycation end products and risk of mortality in patients with cirrhosis: a prospective cohort studyMohsen Shaygan Tabar0Maryam Nilghaz1Azita Hekmatdoost2Fereshteh Pashayee-Khamene3Zeinab Mokhtari4Sara Karimi5Saleheh Ahmadzadeh6Mehdi Saberifiroozi7Behzad Hatami8Zahra Yari9Student Research Committee, Department of Clinical Nutrition and dietetics, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical SciencesClinical Nutrition and dietetics Department, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical SciencesClinical Nutrition and dietetics Department, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical SciencesStudent Research Committee, Ahvaz Jundishapur University of Medical SciencesNutrition and Food Security Research Center, Isfahan University of Medical SciencesClinical Nutrition and dietetics Department, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical SciencesClinical Nutrition and dietetics Department, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical SciencesLiver and Pancreatobiliary Research Center, Digestive Disease Research Institute, Shariati Hospital, Tehran University of Medical SciencesGastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical SciencesDepartment of Nutrition Research, National Nutrition and Food Technology Research Institute, Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical SciencesAbstract The role of diet in reducing the burden of liver disease and mortality attributed to cirrhosis is very imperative. The present study scrutinized the relationship between dietary advanced glycation end products (AGEs) and mortality in patients with cirrhosis. This research was a prospective cohort study on 166 ambulatory cirrhotic patients who had been diagnosed with cirrhosis for a maximum of six months. Follow-up of patients continued for 5 years until May 2024. To determine the incidence of mortality in the quartiles of dietary AGEs, cox regression models were used with the adjustment of potential confounding variables. Although the first model of the analysis by adjusting the results for age and sex failed to show a significant increase in the risk of mortality in patients (HRQ4 vs. Q1 = 2.64; 95% CI = 0.9–7.5, P trend = 0.075), after adjusting the results for further confounders in the second (HRQ4 vs. Q1 = 3.56; 95% CI = 1.1–11.6, P trend = 0.040) and third (HRQ4 vs. Q1 = 3.3; 95% CI = 1.79–13.7, P trend = 0.048) models, the P trend for the risk of mortality during the quartiles of AGEs became significant. In addition, along with increasing trend of dietary AGEs, the number of deaths increased significantly (P = 0.024). Higher mortality risk was generally attributed to higher dietary AGEs in patients with cirrhosis.https://doi.org/10.1038/s41598-025-89433-yAdvanced glycation end productsAGEsMortalityCirrhosis |
| spellingShingle | Mohsen Shaygan Tabar Maryam Nilghaz Azita Hekmatdoost Fereshteh Pashayee-Khamene Zeinab Mokhtari Sara Karimi Saleheh Ahmadzadeh Mehdi Saberifiroozi Behzad Hatami Zahra Yari Advanced glycation end products and risk of mortality in patients with cirrhosis: a prospective cohort study Scientific Reports Advanced glycation end products AGEs Mortality Cirrhosis |
| title | Advanced glycation end products and risk of mortality in patients with cirrhosis: a prospective cohort study |
| title_full | Advanced glycation end products and risk of mortality in patients with cirrhosis: a prospective cohort study |
| title_fullStr | Advanced glycation end products and risk of mortality in patients with cirrhosis: a prospective cohort study |
| title_full_unstemmed | Advanced glycation end products and risk of mortality in patients with cirrhosis: a prospective cohort study |
| title_short | Advanced glycation end products and risk of mortality in patients with cirrhosis: a prospective cohort study |
| title_sort | advanced glycation end products and risk of mortality in patients with cirrhosis a prospective cohort study |
| topic | Advanced glycation end products AGEs Mortality Cirrhosis |
| url | https://doi.org/10.1038/s41598-025-89433-y |
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