Outcomes after Surgery for Malignant Pancreatic Neuroendocrine Tumors
The aim of the study is to declare the role of surgery in potentially curative malignant pancreatic neuroendocrine tumors, in term of prognosis, survival and complications after the surgical procedures. Does the surgery play a significant role in the best patient’s interest even in metastatic pancre...
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| Format: | Article |
| Language: | English |
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Sulaimani Polytechnic University
2019-08-01
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| Series: | Kurdistan Journal of Applied Research |
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| Online Access: | https://kjar.spu.edu.iq/index.php/kjar/article/view/310 |
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| author | Omar Hama Ghalib Azeez Hawramy Karzan Seerwan Abdullah Barham M.M. Salih Qalandar Hussein A. Kasnazani Dana Taib Gharib Dara Ahmed Mohammed |
| author_facet | Omar Hama Ghalib Azeez Hawramy Karzan Seerwan Abdullah Barham M.M. Salih Qalandar Hussein A. Kasnazani Dana Taib Gharib Dara Ahmed Mohammed |
| author_sort | Omar Hama Ghalib Azeez Hawramy |
| collection | DOAJ |
| description | The aim of the study is to declare the role of surgery in potentially curative malignant pancreatic neuroendocrine tumors, in term of prognosis, survival and complications after the surgical procedures. Does the surgery play a significant role in the best patient’s interest even in metastatic pancreatic neuroendocrine tumors? Clinical and pathological factors that changed the outcomes were also analyzed. It is retrospective, case series study. All patients who were undergoing surgery for malignant pancreatic neuroendocrine tumors from 2013 to 2018. Results show that, sixteen patients were recruited with a mean age at diagnosis of 49.31 years, (ranging from 19-80 years). There were 8 male and 8 female patients. Common symptoms were abdominal pain 12 (75%) of them three cases had clinical jaundice 3 (18.8%) and one case had acute pancreatitis and pancreatic necrosis. One (6.3%) patient had functional tumor, and the rest 15 (93.8%) were nonfunctional tumors; all of the patients were sporadic pancreatic neuroendocrine tumors. Overall morbidity was (43.8%) with no perioperative mortality. The median follow-up period was 23 months, ranging from 5-68 months. Recurrence occurred in four cases with a median disease-free interval of 9.5 moths with grade of differentiation (P-value 0.027), lymph node metastases (P-value 0.027) and tumor stage (P-value 0.017) were associated with recurrent disease. The overall 5 year survival was 81.2% and the disease free survival was (75%) at 5 year, with grade of tumor (P-value 0.001), lymph node metastases (P-value 0.001), invasion of other visceral organs(P-value 0.018) and recurrence (P-value 0.001)were associated with decreased survival. In conclusion, pancreatic neuroendocrine tumors have favorable long-term survival after surgical resections even in the presence of liver metastases depending on the grade of differentiation of tumor and lymph node metastases rather than liver metastases and other factors
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| format | Article |
| id | doaj-art-399efb8c65f54b0db46c30de961aaee6 |
| institution | Kabale University |
| issn | 2411-7684 2411-7706 |
| language | English |
| publishDate | 2019-08-01 |
| publisher | Sulaimani Polytechnic University |
| record_format | Article |
| series | Kurdistan Journal of Applied Research |
| spelling | doaj-art-399efb8c65f54b0db46c30de961aaee62025-02-09T21:00:31ZengSulaimani Polytechnic UniversityKurdistan Journal of Applied Research2411-76842411-77062019-08-014310.24017/science.2019.ICHMS.4310Outcomes after Surgery for Malignant Pancreatic Neuroendocrine TumorsOmar Hama Ghalib Azeez Hawramy0Karzan Seerwan Abdullah1Barham M.M. Salih2Qalandar Hussein A. Kasnazani3Dana Taib Gharib4Dara Ahmed Mohammed5Department of Digestive Surgery, Kurdistan Center for Gastroenterology and Hepatology, Ministry of Health Sulaimani, IraqDepartment of Surgery, College of Medicine, University of Sulaimani Sulaimani, IraqDepartment of Surgery, College of Medicine, University of Sulaimani Sulaimani, IraqDepartment of Digestive Surgery, Kurdistan Center for Gastroenterology and Hepatology, Ministry of Health Sulaimani, IraqDepartment of Gastroenterology and Hepatology , Kurdistan Center for Gastroenterology and Hepatology, Ministry of Health Sulaimani, IraqDepartment of Anatomy and Histology, College of Medicine, University of Sulaimani, Sulaimani, IraqThe aim of the study is to declare the role of surgery in potentially curative malignant pancreatic neuroendocrine tumors, in term of prognosis, survival and complications after the surgical procedures. Does the surgery play a significant role in the best patient’s interest even in metastatic pancreatic neuroendocrine tumors? Clinical and pathological factors that changed the outcomes were also analyzed. It is retrospective, case series study. All patients who were undergoing surgery for malignant pancreatic neuroendocrine tumors from 2013 to 2018. Results show that, sixteen patients were recruited with a mean age at diagnosis of 49.31 years, (ranging from 19-80 years). There were 8 male and 8 female patients. Common symptoms were abdominal pain 12 (75%) of them three cases had clinical jaundice 3 (18.8%) and one case had acute pancreatitis and pancreatic necrosis. One (6.3%) patient had functional tumor, and the rest 15 (93.8%) were nonfunctional tumors; all of the patients were sporadic pancreatic neuroendocrine tumors. Overall morbidity was (43.8%) with no perioperative mortality. The median follow-up period was 23 months, ranging from 5-68 months. Recurrence occurred in four cases with a median disease-free interval of 9.5 moths with grade of differentiation (P-value 0.027), lymph node metastases (P-value 0.027) and tumor stage (P-value 0.017) were associated with recurrent disease. The overall 5 year survival was 81.2% and the disease free survival was (75%) at 5 year, with grade of tumor (P-value 0.001), lymph node metastases (P-value 0.001), invasion of other visceral organs(P-value 0.018) and recurrence (P-value 0.001)were associated with decreased survival. In conclusion, pancreatic neuroendocrine tumors have favorable long-term survival after surgical resections even in the presence of liver metastases depending on the grade of differentiation of tumor and lymph node metastases rather than liver metastases and other factors https://kjar.spu.edu.iq/index.php/kjar/article/view/310Pancreatic, Malignant neuroendocrine tumors, Outcomes, Survival, Recurrence. |
| spellingShingle | Omar Hama Ghalib Azeez Hawramy Karzan Seerwan Abdullah Barham M.M. Salih Qalandar Hussein A. Kasnazani Dana Taib Gharib Dara Ahmed Mohammed Outcomes after Surgery for Malignant Pancreatic Neuroendocrine Tumors Kurdistan Journal of Applied Research Pancreatic, Malignant neuroendocrine tumors, Outcomes, Survival, Recurrence. |
| title | Outcomes after Surgery for Malignant Pancreatic Neuroendocrine Tumors |
| title_full | Outcomes after Surgery for Malignant Pancreatic Neuroendocrine Tumors |
| title_fullStr | Outcomes after Surgery for Malignant Pancreatic Neuroendocrine Tumors |
| title_full_unstemmed | Outcomes after Surgery for Malignant Pancreatic Neuroendocrine Tumors |
| title_short | Outcomes after Surgery for Malignant Pancreatic Neuroendocrine Tumors |
| title_sort | outcomes after surgery for malignant pancreatic neuroendocrine tumors |
| topic | Pancreatic, Malignant neuroendocrine tumors, Outcomes, Survival, Recurrence. |
| url | https://kjar.spu.edu.iq/index.php/kjar/article/view/310 |
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