Prevalence of anhedonia in women with deep endometriosis
Abstract Anhedonia, characterized by diminished motivation and pleasure sensitivity, is increasingly recognized as prevalent among patients with chronic pain. Deep Endometriosis (DE), the most severe endophenotype of the disease, is commonly presented with chronic pelvic pain. This cross-sectional s...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-01-01
|
| Series: | Scientific Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1038/s41598-024-84772-8 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1823862644341211136 |
|---|---|
| author | Aida Mallorquí Alessandra Fortuna Emma Segura Gemma Cardona Marta Espinosa Lara Quintas-Marquès Meritxell Gracia Elena Angulo-Antúnez Francisco Carmona María-Angeles Martínez-Zamora |
| author_facet | Aida Mallorquí Alessandra Fortuna Emma Segura Gemma Cardona Marta Espinosa Lara Quintas-Marquès Meritxell Gracia Elena Angulo-Antúnez Francisco Carmona María-Angeles Martínez-Zamora |
| author_sort | Aida Mallorquí |
| collection | DOAJ |
| description | Abstract Anhedonia, characterized by diminished motivation and pleasure sensitivity, is increasingly recognized as prevalent among patients with chronic pain. Deep Endometriosis (DE), the most severe endophenotype of the disease, is commonly presented with chronic pelvic pain. This cross-sectional study reports, for the first time, the prevalence of anhedonia in a sample comprised by 212 premenopausal women with suspected DE referred to a tertiary hospital. Our findings show that 27,8% [95% CI 22.1, 26.5] of DE patients experience abnormal hedonic tone. Severity of DE pain-related symptoms significantly correlated with anhedonia, consistent with previous findings. Chronic pelvic pain emerged as a significant predictor of anhedonia (OR 1.5, 95% CI 1.0–1.22, p < 0.05) with the odds increasing to 2.28 [95% CI 1.12, 4.23] when pain was severe. The most affected areas in DE patients were interests, social interaction and food pleasure. The present results are representative of DE patients under multimodal treatment, limiting generalizability. Overall, our study highlights the impact of chronic pain on hedonic functioning in DE. Therapeutic approaches targeting hedonic capacity in DE patients are crucial for restoring health and well-being. |
| format | Article |
| id | doaj-art-39c7fecd10cf4d7c94ba6c8566683bf0 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-39c7fecd10cf4d7c94ba6c8566683bf02025-02-09T12:28:35ZengNature PortfolioScientific Reports2045-23222025-01-0115111210.1038/s41598-024-84772-8Prevalence of anhedonia in women with deep endometriosisAida Mallorquí0Alessandra Fortuna1Emma Segura2Gemma Cardona3Marta Espinosa4Lara Quintas-Marquès5Meritxell Gracia6Elena Angulo-Antúnez7Francisco Carmona8María-Angeles Martínez-Zamora9Clinical Health Psychology Section, Institute of Neuroscience (ICN), Hospital ClinicGynecology Department Institute Clinic of Gynecology, Obstetrics and Neonatology, Hospital Clinic, Faculty of Medicine, Institut d’Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), University of BarcelonaCognition and Brain Plasticity Unit, Bellvitge Biomedical Research Institute, L’Hospitalet de LlobregatCognition and Brain Plasticity Unit, Bellvitge Biomedical Research Institute, L’Hospitalet de LlobregatClinical Health Psychology Section, Institute of Neuroscience (ICN), Hospital ClinicGynecology Department Institute Clinic of Gynecology, Obstetrics and Neonatology, Hospital Clinic, Faculty of Medicine, Institut d’Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), University of BarcelonaGynecology Department Institute Clinic of Gynecology, Obstetrics and Neonatology, Hospital Clinic, Faculty of Medicine, Institut d’Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), University of BarcelonaClinical Health Psychology Section, Institute of Neuroscience (ICN), Hospital ClinicGynecology Department Institute Clinic of Gynecology, Obstetrics and Neonatology, Hospital Clinic, Faculty of Medicine, Institut d’Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), University of BarcelonaGynecology Department Institute Clinic of Gynecology, Obstetrics and Neonatology, Hospital Clinic, Faculty of Medicine, Institut d’Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), University of BarcelonaAbstract Anhedonia, characterized by diminished motivation and pleasure sensitivity, is increasingly recognized as prevalent among patients with chronic pain. Deep Endometriosis (DE), the most severe endophenotype of the disease, is commonly presented with chronic pelvic pain. This cross-sectional study reports, for the first time, the prevalence of anhedonia in a sample comprised by 212 premenopausal women with suspected DE referred to a tertiary hospital. Our findings show that 27,8% [95% CI 22.1, 26.5] of DE patients experience abnormal hedonic tone. Severity of DE pain-related symptoms significantly correlated with anhedonia, consistent with previous findings. Chronic pelvic pain emerged as a significant predictor of anhedonia (OR 1.5, 95% CI 1.0–1.22, p < 0.05) with the odds increasing to 2.28 [95% CI 1.12, 4.23] when pain was severe. The most affected areas in DE patients were interests, social interaction and food pleasure. The present results are representative of DE patients under multimodal treatment, limiting generalizability. Overall, our study highlights the impact of chronic pain on hedonic functioning in DE. Therapeutic approaches targeting hedonic capacity in DE patients are crucial for restoring health and well-being.https://doi.org/10.1038/s41598-024-84772-8AnhedoniaEndometriosisDeep endometriosisChronic pelvic painChronic painInflammation |
| spellingShingle | Aida Mallorquí Alessandra Fortuna Emma Segura Gemma Cardona Marta Espinosa Lara Quintas-Marquès Meritxell Gracia Elena Angulo-Antúnez Francisco Carmona María-Angeles Martínez-Zamora Prevalence of anhedonia in women with deep endometriosis Scientific Reports Anhedonia Endometriosis Deep endometriosis Chronic pelvic pain Chronic pain Inflammation |
| title | Prevalence of anhedonia in women with deep endometriosis |
| title_full | Prevalence of anhedonia in women with deep endometriosis |
| title_fullStr | Prevalence of anhedonia in women with deep endometriosis |
| title_full_unstemmed | Prevalence of anhedonia in women with deep endometriosis |
| title_short | Prevalence of anhedonia in women with deep endometriosis |
| title_sort | prevalence of anhedonia in women with deep endometriosis |
| topic | Anhedonia Endometriosis Deep endometriosis Chronic pelvic pain Chronic pain Inflammation |
| url | https://doi.org/10.1038/s41598-024-84772-8 |
| work_keys_str_mv | AT aidamallorqui prevalenceofanhedoniainwomenwithdeependometriosis AT alessandrafortuna prevalenceofanhedoniainwomenwithdeependometriosis AT emmasegura prevalenceofanhedoniainwomenwithdeependometriosis AT gemmacardona prevalenceofanhedoniainwomenwithdeependometriosis AT martaespinosa prevalenceofanhedoniainwomenwithdeependometriosis AT laraquintasmarques prevalenceofanhedoniainwomenwithdeependometriosis AT meritxellgracia prevalenceofanhedoniainwomenwithdeependometriosis AT elenaanguloantunez prevalenceofanhedoniainwomenwithdeependometriosis AT franciscocarmona prevalenceofanhedoniainwomenwithdeependometriosis AT mariaangelesmartinezzamora prevalenceofanhedoniainwomenwithdeependometriosis |