Preventive role of Pastinaca sativa in mitigating metabolic dysfunction-associated steatotic liver disease via modulation of metabolic endotoxemia
Abstract Metabolic dysfunction-associated steatotic liver disease (MASLD) is a leading global liver disorder. Parsnip (Pastinaca sativa), rich in dietary fiber and medicinal properties, has shown health benefits, but its effects on MASLD are largely unexplored. This study evaluated the prebiotic and...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-02-01
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| Series: | npj Science of Food |
| Online Access: | https://doi.org/10.1038/s41538-024-00366-8 |
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| author | Ji-Eun Park Hye-Bin Lee Yu Ra Lee Guijae Yoo Hee-Kyoung Son Sang Yoon Choi Miri Park Ho-Young Park |
| author_facet | Ji-Eun Park Hye-Bin Lee Yu Ra Lee Guijae Yoo Hee-Kyoung Son Sang Yoon Choi Miri Park Ho-Young Park |
| author_sort | Ji-Eun Park |
| collection | DOAJ |
| description | Abstract Metabolic dysfunction-associated steatotic liver disease (MASLD) is a leading global liver disorder. Parsnip (Pastinaca sativa), rich in dietary fiber and medicinal properties, has shown health benefits, but its effects on MASLD are largely unexplored. This study evaluated the prebiotic and anti-MASLD effects of parsnip root water-soluble extract (PRE) in a mouse model. Mice fed a high-fat diet with 50 or 100 mg/kg PRE for eight weeks showed reduced fat accumulation, improved serum metabolic profiles, and decreased liver injury markers. PRE also lowered hepatic lipogenic protein levels induced by the high-fat diet. Additionally, PRE enhanced gut health by reducing endotoxins, improving intestinal permeability, and upregulating tight junction proteins. These results indicate that PRE can improve gut health, prevent MASLD, and support its potential as a dietary supplement to enhance metabolic health. |
| format | Article |
| id | doaj-art-39fac8896d3e4a80a88fc9d2b7353865 |
| institution | Kabale University |
| issn | 2396-8370 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Science of Food |
| spelling | doaj-art-39fac8896d3e4a80a88fc9d2b73538652025-02-09T12:56:07ZengNature Portfolionpj Science of Food2396-83702025-02-019111210.1038/s41538-024-00366-8Preventive role of Pastinaca sativa in mitigating metabolic dysfunction-associated steatotic liver disease via modulation of metabolic endotoxemiaJi-Eun Park0Hye-Bin Lee1Yu Ra Lee2Guijae Yoo3Hee-Kyoung Son4Sang Yoon Choi5Miri Park6Ho-Young Park7Food Functionality Research Division, Korea Food Research InstituteFood Functionality Research Division, Korea Food Research InstituteFood Functionality Research Division, Korea Food Research InstituteFood Functionality Research Division, Korea Food Research InstituteFood Functionality Research Division, Korea Food Research InstituteFood Functionality Research Division, Korea Food Research InstituteFood Functionality Research Division, Korea Food Research InstituteFood Functionality Research Division, Korea Food Research InstituteAbstract Metabolic dysfunction-associated steatotic liver disease (MASLD) is a leading global liver disorder. Parsnip (Pastinaca sativa), rich in dietary fiber and medicinal properties, has shown health benefits, but its effects on MASLD are largely unexplored. This study evaluated the prebiotic and anti-MASLD effects of parsnip root water-soluble extract (PRE) in a mouse model. Mice fed a high-fat diet with 50 or 100 mg/kg PRE for eight weeks showed reduced fat accumulation, improved serum metabolic profiles, and decreased liver injury markers. PRE also lowered hepatic lipogenic protein levels induced by the high-fat diet. Additionally, PRE enhanced gut health by reducing endotoxins, improving intestinal permeability, and upregulating tight junction proteins. These results indicate that PRE can improve gut health, prevent MASLD, and support its potential as a dietary supplement to enhance metabolic health.https://doi.org/10.1038/s41538-024-00366-8 |
| spellingShingle | Ji-Eun Park Hye-Bin Lee Yu Ra Lee Guijae Yoo Hee-Kyoung Son Sang Yoon Choi Miri Park Ho-Young Park Preventive role of Pastinaca sativa in mitigating metabolic dysfunction-associated steatotic liver disease via modulation of metabolic endotoxemia npj Science of Food |
| title | Preventive role of Pastinaca sativa in mitigating metabolic dysfunction-associated steatotic liver disease via modulation of metabolic endotoxemia |
| title_full | Preventive role of Pastinaca sativa in mitigating metabolic dysfunction-associated steatotic liver disease via modulation of metabolic endotoxemia |
| title_fullStr | Preventive role of Pastinaca sativa in mitigating metabolic dysfunction-associated steatotic liver disease via modulation of metabolic endotoxemia |
| title_full_unstemmed | Preventive role of Pastinaca sativa in mitigating metabolic dysfunction-associated steatotic liver disease via modulation of metabolic endotoxemia |
| title_short | Preventive role of Pastinaca sativa in mitigating metabolic dysfunction-associated steatotic liver disease via modulation of metabolic endotoxemia |
| title_sort | preventive role of pastinaca sativa in mitigating metabolic dysfunction associated steatotic liver disease via modulation of metabolic endotoxemia |
| url | https://doi.org/10.1038/s41538-024-00366-8 |
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