Antimicrobial Susceptibility of <i>Salmonella typhi</i> and <i>paratyphi</i> among Pediatric Population at Tertiary Care Center of North Delhi: A Retrospective Study
Background: Enteric fever continues to impact millions of children who lack adequate access to clean water and sanitation. Enteric fever remains a major concern in India with an estimated incidence from hospital surveillance ranging from 12 to 1,622 cases per 100,000 child-years among children betwe...
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| Format: | Article |
| Language: | English |
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Jaypee Brothers Medical Publisher
2024-07-01
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| Series: | Pediatric Infectious Disease |
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| Online Access: | https://www.pidjournal.com/doi/PID/pdf/10.5005/jp-journals-10081-1428 |
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| author | Shekhar Biswas Sulagna Tripathy Arvind Kumar Sanjay Chattree |
| author_facet | Shekhar Biswas Sulagna Tripathy Arvind Kumar Sanjay Chattree |
| author_sort | Shekhar Biswas |
| collection | DOAJ |
| description | Background: Enteric fever continues to impact millions of children who lack adequate access to clean water and sanitation. Enteric fever remains a major concern in India with an estimated incidence from hospital surveillance ranging from 12 to 1,622 cases per 100,000 child-years among children between the ages of 6 months and 14 years, and from 108 to 970 cases per 100,000 person-years among those who are 15 years of age or older. With the inappropriate use of antibiotics and rising trends of multidrug-resistant (MDR) and extensively drug-resistant (XDR) typhoid, it is becoming a public health emergency. This study evaluated the current trends in antibiotic susceptibilities to <i>Salmonella typhi</i> and <i>paratyphi</i> A and B in North Delhi.
Materials and methods: We undertook a retrospective, cross-sectional multicentric study by reviewing hospital-based laboratory records of pediatric patients (up to age 18 years) whose blood culture samples were submitted from the outpatient and inpatient departments to the laboratories of Jaipur Golden Hospital in Rohini and Fortis Hospital in Shalimar Bagh, Delhi, India from September 2022 to September 2023.
Results: There were 121 (75.15%) children with <i>S. typhi</i> and 40 (24.84%) with <i>S. paratyphi</i> isolates. The median age of patients was 8 years with male and female patients constituting 61.4 and 38.5%, respectively. The disease was prevalent throughout the year with high prevalence between March and May. There were four cases of MDR typhoid (2.4%) and two cases of XDR typhoid (1.2%).
Conclusion: <i>S. typhi</i> was the predominant serotype. The study also shows that infection with <i>S. paratyphi</i> is not distant second as it contributes for significant 25% of total enteric fever infection. Alarming multiple drug resistance patterns were not observed. Third-generation cephalosporins as monotherapy are quite effective, and there is no need of adding azithromycin in combination form. Effective mass vaccination strategy against typhoid and water and safe hygiene (WASH) practices can decrease the burden of this disease. Broad-spectrum vaccine to cover both <i>S. typhi</i> and <i>S. paratyphi</i> is need of the hour. |
| format | Article |
| id | doaj-art-3bb9c103f9d247afb6df6a62fecd1b6f |
| institution | Kabale University |
| issn | 2582-4988 |
| language | English |
| publishDate | 2024-07-01 |
| publisher | Jaypee Brothers Medical Publisher |
| record_format | Article |
| series | Pediatric Infectious Disease |
| spelling | doaj-art-3bb9c103f9d247afb6df6a62fecd1b6f2025-02-07T11:21:56ZengJaypee Brothers Medical PublisherPediatric Infectious Disease2582-49882024-07-0163889110.5005/jp-journals-10081-14283Antimicrobial Susceptibility of <i>Salmonella typhi</i> and <i>paratyphi</i> among Pediatric Population at Tertiary Care Center of North Delhi: A Retrospective StudyShekhar Biswas0Sulagna Tripathy1Arvind Kumar2Sanjay Chattree3Shekhar Biswas, Department of Paediatrics, Jaipur Golden Hospital, Delhi, India, Phone: +91 9650746689Department of Paediatrics, Jaipur Golden Hospital, Delhi, IndiaDepartment of Paediatrics, Fortis Hospital, Shalimar Bagh, Delhi, IndiaDepartment of Paediatrics, Jaipur Golden Hospital, Delhi, IndiaBackground: Enteric fever continues to impact millions of children who lack adequate access to clean water and sanitation. Enteric fever remains a major concern in India with an estimated incidence from hospital surveillance ranging from 12 to 1,622 cases per 100,000 child-years among children between the ages of 6 months and 14 years, and from 108 to 970 cases per 100,000 person-years among those who are 15 years of age or older. With the inappropriate use of antibiotics and rising trends of multidrug-resistant (MDR) and extensively drug-resistant (XDR) typhoid, it is becoming a public health emergency. This study evaluated the current trends in antibiotic susceptibilities to <i>Salmonella typhi</i> and <i>paratyphi</i> A and B in North Delhi. Materials and methods: We undertook a retrospective, cross-sectional multicentric study by reviewing hospital-based laboratory records of pediatric patients (up to age 18 years) whose blood culture samples were submitted from the outpatient and inpatient departments to the laboratories of Jaipur Golden Hospital in Rohini and Fortis Hospital in Shalimar Bagh, Delhi, India from September 2022 to September 2023. Results: There were 121 (75.15%) children with <i>S. typhi</i> and 40 (24.84%) with <i>S. paratyphi</i> isolates. The median age of patients was 8 years with male and female patients constituting 61.4 and 38.5%, respectively. The disease was prevalent throughout the year with high prevalence between March and May. There were four cases of MDR typhoid (2.4%) and two cases of XDR typhoid (1.2%). Conclusion: <i>S. typhi</i> was the predominant serotype. The study also shows that infection with <i>S. paratyphi</i> is not distant second as it contributes for significant 25% of total enteric fever infection. Alarming multiple drug resistance patterns were not observed. Third-generation cephalosporins as monotherapy are quite effective, and there is no need of adding azithromycin in combination form. Effective mass vaccination strategy against typhoid and water and safe hygiene (WASH) practices can decrease the burden of this disease. Broad-spectrum vaccine to cover both <i>S. typhi</i> and <i>S. paratyphi</i> is need of the hour.https://www.pidjournal.com/doi/PID/pdf/10.5005/jp-journals-10081-1428antimicrobial sensitivityblood<i>salmonella typhi</i> and <i>paratyphi</i> in indian childrentyphoid conjugate vaccinetyphoid fevertyphoid |
| spellingShingle | Shekhar Biswas Sulagna Tripathy Arvind Kumar Sanjay Chattree Antimicrobial Susceptibility of <i>Salmonella typhi</i> and <i>paratyphi</i> among Pediatric Population at Tertiary Care Center of North Delhi: A Retrospective Study Pediatric Infectious Disease antimicrobial sensitivity blood <i>salmonella typhi</i> and <i>paratyphi</i> in indian children typhoid conjugate vaccine typhoid fever typhoid |
| title | Antimicrobial Susceptibility of <i>Salmonella typhi</i> and <i>paratyphi</i> among Pediatric Population at Tertiary Care Center of North Delhi: A Retrospective Study |
| title_full | Antimicrobial Susceptibility of <i>Salmonella typhi</i> and <i>paratyphi</i> among Pediatric Population at Tertiary Care Center of North Delhi: A Retrospective Study |
| title_fullStr | Antimicrobial Susceptibility of <i>Salmonella typhi</i> and <i>paratyphi</i> among Pediatric Population at Tertiary Care Center of North Delhi: A Retrospective Study |
| title_full_unstemmed | Antimicrobial Susceptibility of <i>Salmonella typhi</i> and <i>paratyphi</i> among Pediatric Population at Tertiary Care Center of North Delhi: A Retrospective Study |
| title_short | Antimicrobial Susceptibility of <i>Salmonella typhi</i> and <i>paratyphi</i> among Pediatric Population at Tertiary Care Center of North Delhi: A Retrospective Study |
| title_sort | antimicrobial susceptibility of i salmonella typhi i and i paratyphi i among pediatric population at tertiary care center of north delhi a retrospective study |
| topic | antimicrobial sensitivity blood <i>salmonella typhi</i> and <i>paratyphi</i> in indian children typhoid conjugate vaccine typhoid fever typhoid |
| url | https://www.pidjournal.com/doi/PID/pdf/10.5005/jp-journals-10081-1428 |
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