Pharmacokinetic/pharmacodynamic analysis of tedizolid phosphate against Staphylococcus aureus and Streptococcus pneumoniae in children, adolescents, and adults by Monte Carlo simulation
Objective: The objective of this study was to investigate the cumulative fraction of response of various dosage regimens of tedizolid phosphate against Staphylococcus aureus and Streptococcus pneumoniae in children, adolescents, and adults. Methods: Monte Carlo simulations were performed using previ...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-01-01
|
| Series: | Journal of Global Antimicrobial Resistance |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213716524004521 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1825199405202931712 |
|---|---|
| author | Xiao-Chen Wei Ming-Feng Zhao Hai-Rong Lv Xia Xiao |
| author_facet | Xiao-Chen Wei Ming-Feng Zhao Hai-Rong Lv Xia Xiao |
| author_sort | Xiao-Chen Wei |
| collection | DOAJ |
| description | Objective: The objective of this study was to investigate the cumulative fraction of response of various dosage regimens of tedizolid phosphate against Staphylococcus aureus and Streptococcus pneumoniae in children, adolescents, and adults. Methods: Monte Carlo simulations were performed using previously published pharmacokinetic parameters and pharmacodynamic data to evaluate the efficacy of the simulated dosage strategies in terms of area under the concentration-time curve/minimum inhibitory concentration targets of tedizolid. Results: According to the results of the Monte Carlo simulations, currently approved dosage regimens of tedizolid phosphate were effective in the treatment of acute bacterial skin and skin structure infections (ABSSSIs) caused by methicillin-susceptible S. aureus and methicillin-resistant S. aureus (MRSA) including vancomycin-intermediate, heterogeneous vancomycin-intermediate, and daptomycin-non-susceptible MRSA in adult and paediatric patients aged 12 y and older. High-dose regimens of tedizolid phosphate should be the preferred option to optimize efficacy against ABSSSIs caused by linezolid-resistant MRSA, particularly chloramphenicol-florfenicol resistance-mediated isolates. The dosage regimens of 3 and 4 mg/kg/d of tedizolid phosphate were appropriate to treat ABSSSIs caused by methicillin-susceptible S. aureus and MRSA in children aged 2–6 and 6–12 y, respectively. Approved dosage regimens of tedizolid phosphate for patients older than 12 y may be sufficient against S. pneumoniae pneumonia but insufficient for S. aureus pneumonia. For neutropenic patients, almost all the simulated regimens of tedizolid phosphate were ineffective against S. aureus and S. pneumoniae. Conclusions: These pharmacokinetics/pharmacodynamics-based simulations rationalize and optimize the dosage regimens of tedizolid phosphate against S. aureus and S. pneumoniae in children, adolescents, and adults. |
| format | Article |
| id | doaj-art-3cb774ced5384e4c9f54903d1fdf46bd |
| institution | Kabale University |
| issn | 2213-7165 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Global Antimicrobial Resistance |
| spelling | doaj-art-3cb774ced5384e4c9f54903d1fdf46bd2025-02-08T05:00:26ZengElsevierJournal of Global Antimicrobial Resistance2213-71652025-01-01401525Pharmacokinetic/pharmacodynamic analysis of tedizolid phosphate against Staphylococcus aureus and Streptococcus pneumoniae in children, adolescents, and adults by Monte Carlo simulationXiao-Chen Wei0Ming-Feng Zhao1Hai-Rong Lv2Xia Xiao3Department of Pharmacy, Tianjin First Central Hospital, Tianjin, PR China; Corresponding author. Mailing address: Department of Pharmacy, Tianjin First Central Hospital, No.24, Fukang Road, Nankai District, Tianjin 300192, PR China.Department of Hematology, Tianjin First Central Hospital, Tianjin, PR ChinaDepartment of Hematology, Tianjin First Central Hospital, Tianjin, PR ChinaDepartment of Hematology, Tianjin First Central Hospital, Tianjin, PR ChinaObjective: The objective of this study was to investigate the cumulative fraction of response of various dosage regimens of tedizolid phosphate against Staphylococcus aureus and Streptococcus pneumoniae in children, adolescents, and adults. Methods: Monte Carlo simulations were performed using previously published pharmacokinetic parameters and pharmacodynamic data to evaluate the efficacy of the simulated dosage strategies in terms of area under the concentration-time curve/minimum inhibitory concentration targets of tedizolid. Results: According to the results of the Monte Carlo simulations, currently approved dosage regimens of tedizolid phosphate were effective in the treatment of acute bacterial skin and skin structure infections (ABSSSIs) caused by methicillin-susceptible S. aureus and methicillin-resistant S. aureus (MRSA) including vancomycin-intermediate, heterogeneous vancomycin-intermediate, and daptomycin-non-susceptible MRSA in adult and paediatric patients aged 12 y and older. High-dose regimens of tedizolid phosphate should be the preferred option to optimize efficacy against ABSSSIs caused by linezolid-resistant MRSA, particularly chloramphenicol-florfenicol resistance-mediated isolates. The dosage regimens of 3 and 4 mg/kg/d of tedizolid phosphate were appropriate to treat ABSSSIs caused by methicillin-susceptible S. aureus and MRSA in children aged 2–6 and 6–12 y, respectively. Approved dosage regimens of tedizolid phosphate for patients older than 12 y may be sufficient against S. pneumoniae pneumonia but insufficient for S. aureus pneumonia. For neutropenic patients, almost all the simulated regimens of tedizolid phosphate were ineffective against S. aureus and S. pneumoniae. Conclusions: These pharmacokinetics/pharmacodynamics-based simulations rationalize and optimize the dosage regimens of tedizolid phosphate against S. aureus and S. pneumoniae in children, adolescents, and adults.http://www.sciencedirect.com/science/article/pii/S2213716524004521Tedizolid phosphateStaphylococcus aureusStreptococcus pneumoniaePharmacokinetics/pharmacodynamicsMonte Carlo simulation |
| spellingShingle | Xiao-Chen Wei Ming-Feng Zhao Hai-Rong Lv Xia Xiao Pharmacokinetic/pharmacodynamic analysis of tedizolid phosphate against Staphylococcus aureus and Streptococcus pneumoniae in children, adolescents, and adults by Monte Carlo simulation Journal of Global Antimicrobial Resistance Tedizolid phosphate Staphylococcus aureus Streptococcus pneumoniae Pharmacokinetics/pharmacodynamics Monte Carlo simulation |
| title | Pharmacokinetic/pharmacodynamic analysis of tedizolid phosphate against Staphylococcus aureus and Streptococcus pneumoniae in children, adolescents, and adults by Monte Carlo simulation |
| title_full | Pharmacokinetic/pharmacodynamic analysis of tedizolid phosphate against Staphylococcus aureus and Streptococcus pneumoniae in children, adolescents, and adults by Monte Carlo simulation |
| title_fullStr | Pharmacokinetic/pharmacodynamic analysis of tedizolid phosphate against Staphylococcus aureus and Streptococcus pneumoniae in children, adolescents, and adults by Monte Carlo simulation |
| title_full_unstemmed | Pharmacokinetic/pharmacodynamic analysis of tedizolid phosphate against Staphylococcus aureus and Streptococcus pneumoniae in children, adolescents, and adults by Monte Carlo simulation |
| title_short | Pharmacokinetic/pharmacodynamic analysis of tedizolid phosphate against Staphylococcus aureus and Streptococcus pneumoniae in children, adolescents, and adults by Monte Carlo simulation |
| title_sort | pharmacokinetic pharmacodynamic analysis of tedizolid phosphate against staphylococcus aureus and streptococcus pneumoniae in children adolescents and adults by monte carlo simulation |
| topic | Tedizolid phosphate Staphylococcus aureus Streptococcus pneumoniae Pharmacokinetics/pharmacodynamics Monte Carlo simulation |
| url | http://www.sciencedirect.com/science/article/pii/S2213716524004521 |
| work_keys_str_mv | AT xiaochenwei pharmacokineticpharmacodynamicanalysisoftedizolidphosphateagainststaphylococcusaureusandstreptococcuspneumoniaeinchildrenadolescentsandadultsbymontecarlosimulation AT mingfengzhao pharmacokineticpharmacodynamicanalysisoftedizolidphosphateagainststaphylococcusaureusandstreptococcuspneumoniaeinchildrenadolescentsandadultsbymontecarlosimulation AT haironglv pharmacokineticpharmacodynamicanalysisoftedizolidphosphateagainststaphylococcusaureusandstreptococcuspneumoniaeinchildrenadolescentsandadultsbymontecarlosimulation AT xiaxiao pharmacokineticpharmacodynamicanalysisoftedizolidphosphateagainststaphylococcusaureusandstreptococcuspneumoniaeinchildrenadolescentsandadultsbymontecarlosimulation |