l-Tyrosine and l-DOPA: Promising scaffolds for the synthesis of biologically active compounds
This review reports the synthetic strategies as well as the physicochemical and biological properties of l-tyrosine and 3,4-dihydroxyphenyl-l-alanine (l-DOPA) esters, amides, and imine derivatives including dopamines and tyrosol derivatives from 2010 to 2024. The variations in head group and hydroph...
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| Format: | Article |
| Language: | English |
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Académie des sciences
2024-11-01
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| Series: | Comptes Rendus. Chimie |
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| Online Access: | https://comptes-rendus.academie-sciences.fr/chimie/articles/10.5802/crchim.342/ |
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| author | Ndayiragije, Euphrem Caumul, Prakashanand Joondan, Nausheen Bhowon, Minu Gupta Jhaumeer Laulloo, Sabina |
| author_facet | Ndayiragije, Euphrem Caumul, Prakashanand Joondan, Nausheen Bhowon, Minu Gupta Jhaumeer Laulloo, Sabina |
| author_sort | Ndayiragije, Euphrem |
| collection | DOAJ |
| description | This review reports the synthetic strategies as well as the physicochemical and biological properties of l-tyrosine and 3,4-dihydroxyphenyl-l-alanine (l-DOPA) esters, amides, and imine derivatives including dopamines and tyrosol derivatives from 2010 to 2024. The variations in head group and hydrophilic chain were found to influence the physicochemical properties such as critical micelle concentration (CMC), lipophilicity, and surface tension. The biological properties of the previously reported l-tyrosine and l-DOPA derivatives such as radical scavenging, antibacterial, antiproliferative, and anti-Parkinson activities are also reported. |
| format | Article |
| id | doaj-art-3d1ed4dc2e484cb39f84cbccdc2d9153 |
| institution | Kabale University |
| issn | 1878-1543 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Académie des sciences |
| record_format | Article |
| series | Comptes Rendus. Chimie |
| spelling | doaj-art-3d1ed4dc2e484cb39f84cbccdc2d91532025-02-07T13:39:46ZengAcadémie des sciencesComptes Rendus. Chimie1878-15432024-11-0127G129931710.5802/crchim.34210.5802/crchim.342l-Tyrosine and l-DOPA: Promising scaffolds for the synthesis of biologically active compoundsNdayiragije, Euphrem0https://orcid.org/0000-0003-4604-8053Caumul, Prakashanand1https://orcid.org/0000-0002-1819-2595Joondan, Nausheen2https://orcid.org/0000-0002-1981-0332 Bhowon, Minu Gupta3https://orcid.org/0000-0003-1942-6098Jhaumeer Laulloo, Sabina4https://orcid.org/0000-0001-8841-9276Department of Chemistry, Faculty of Science, University of Burundi, Bujumbura, Burundi; Department of Chemistry, Faculty of Science, University of Mauritius, Réduit, MauritiusDepartment of Chemistry, Faculty of Science, University of Mauritius, Réduit, MauritiusDepartment of Chemistry, Faculty of Science, University of Mauritius, Réduit, MauritiusDepartment of Chemistry, Faculty of Science, University of Mauritius, Réduit, MauritiusDepartment of Chemistry, Faculty of Science, University of Mauritius, Réduit, MauritiusThis review reports the synthetic strategies as well as the physicochemical and biological properties of l-tyrosine and 3,4-dihydroxyphenyl-l-alanine (l-DOPA) esters, amides, and imine derivatives including dopamines and tyrosol derivatives from 2010 to 2024. The variations in head group and hydrophilic chain were found to influence the physicochemical properties such as critical micelle concentration (CMC), lipophilicity, and surface tension. The biological properties of the previously reported l-tyrosine and l-DOPA derivatives such as radical scavenging, antibacterial, antiproliferative, and anti-Parkinson activities are also reported.https://comptes-rendus.academie-sciences.fr/chimie/articles/10.5802/crchim.342/<span class="smallcaps">l</span>-Tyrosine<span class="smallcaps">l</span>-DOPAPhysicochemical propertiesBiological activities |
| spellingShingle | Ndayiragije, Euphrem Caumul, Prakashanand Joondan, Nausheen Bhowon, Minu Gupta Jhaumeer Laulloo, Sabina l-Tyrosine and l-DOPA: Promising scaffolds for the synthesis of biologically active compounds Comptes Rendus. Chimie <span class="smallcaps">l</span>-Tyrosine <span class="smallcaps">l</span>-DOPA Physicochemical properties Biological activities |
| title | l-Tyrosine and l-DOPA: Promising scaffolds for the synthesis of biologically active compounds |
| title_full | l-Tyrosine and l-DOPA: Promising scaffolds for the synthesis of biologically active compounds |
| title_fullStr | l-Tyrosine and l-DOPA: Promising scaffolds for the synthesis of biologically active compounds |
| title_full_unstemmed | l-Tyrosine and l-DOPA: Promising scaffolds for the synthesis of biologically active compounds |
| title_short | l-Tyrosine and l-DOPA: Promising scaffolds for the synthesis of biologically active compounds |
| title_sort | l tyrosine and l dopa promising scaffolds for the synthesis of biologically active compounds |
| topic | <span class="smallcaps">l</span>-Tyrosine <span class="smallcaps">l</span>-DOPA Physicochemical properties Biological activities |
| url | https://comptes-rendus.academie-sciences.fr/chimie/articles/10.5802/crchim.342/ |
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