Synthesis of trehalose-based chemical tools for the study of the mycobacterial membrane
Corynebacteriales including the causative agent of many diseases such as tuberculosis are known to be extremely resistant against external stress as well as to antibiotic treatments which is believed to be related to the singular architecture of their mycomembrane. Over the last decades, both bioort...
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| Format: | Article |
| Language: | English |
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Académie des sciences
2023-10-01
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| Series: | Comptes Rendus. Chimie |
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| Online Access: | https://comptes-rendus.academie-sciences.fr/chimie/articles/10.5802/crchim.246/ |
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| author | Lesur, Emilie Rollando, Paulin Guianvarc’h, Dominique Bourdreux, Yann |
| author_facet | Lesur, Emilie Rollando, Paulin Guianvarc’h, Dominique Bourdreux, Yann |
| author_sort | Lesur, Emilie |
| collection | DOAJ |
| description | Corynebacteriales including the causative agent of many diseases such as tuberculosis are known to be extremely resistant against external stress as well as to antibiotic treatments which is believed to be related to the singular architecture of their mycomembrane. Over the last decades, both bioorthogonal chemical reporters and fluorescent probes for the metabolic labeling of bacterial cell glycans were developed including several trehalose-based probes to study the dynamics of mycomembrane components. This review presents an exhaustive view on the reported syntheses of trehalose-based probes enabling the study of the mycomembrane biogenesis. |
| format | Article |
| id | doaj-art-3d39a0cc69af4ced8771da85b70edb3c |
| institution | Kabale University |
| issn | 1878-1543 |
| language | English |
| publishDate | 2023-10-01 |
| publisher | Académie des sciences |
| record_format | Article |
| series | Comptes Rendus. Chimie |
| spelling | doaj-art-3d39a0cc69af4ced8771da85b70edb3c2025-02-07T13:38:53ZengAcadémie des sciencesComptes Rendus. Chimie1878-15432023-10-0126S3173810.5802/crchim.24610.5802/crchim.246Synthesis of trehalose-based chemical tools for the study of the mycobacterial membraneLesur, Emilie0https://orcid.org/0009-0000-6729-1701Rollando, Paulin1Guianvarc’h, Dominique2https://orcid.org/0000-0002-7722-370XBourdreux, Yann3https://orcid.org/0000-0001-6653-7685Université Paris-Saclay, CNRS, Institut de Chimie Moléculaire et des Matériaux d’Orsay, UMR 8182, 91405, Orsay, FranceUniversité Paris-Saclay, CNRS, Institut de Chimie Moléculaire et des Matériaux d’Orsay, UMR 8182, 91405, Orsay, FranceUniversité Paris-Saclay, CNRS, Institut de Chimie Moléculaire et des Matériaux d’Orsay, UMR 8182, 91405, Orsay, FranceUniversité Paris-Saclay, CNRS, Institut de Chimie Moléculaire et des Matériaux d’Orsay, UMR 8182, 91405, Orsay, FranceCorynebacteriales including the causative agent of many diseases such as tuberculosis are known to be extremely resistant against external stress as well as to antibiotic treatments which is believed to be related to the singular architecture of their mycomembrane. Over the last decades, both bioorthogonal chemical reporters and fluorescent probes for the metabolic labeling of bacterial cell glycans were developed including several trehalose-based probes to study the dynamics of mycomembrane components. This review presents an exhaustive view on the reported syntheses of trehalose-based probes enabling the study of the mycomembrane biogenesis.https://comptes-rendus.academie-sciences.fr/chimie/articles/10.5802/crchim.246/Chemical reporterMetabolic labelingBioorthogonal probeTrehaloseMycomembraneCorynebacteriales |
| spellingShingle | Lesur, Emilie Rollando, Paulin Guianvarc’h, Dominique Bourdreux, Yann Synthesis of trehalose-based chemical tools for the study of the mycobacterial membrane Comptes Rendus. Chimie Chemical reporter Metabolic labeling Bioorthogonal probe Trehalose Mycomembrane Corynebacteriales |
| title | Synthesis of trehalose-based chemical tools for the study of the mycobacterial membrane |
| title_full | Synthesis of trehalose-based chemical tools for the study of the mycobacterial membrane |
| title_fullStr | Synthesis of trehalose-based chemical tools for the study of the mycobacterial membrane |
| title_full_unstemmed | Synthesis of trehalose-based chemical tools for the study of the mycobacterial membrane |
| title_short | Synthesis of trehalose-based chemical tools for the study of the mycobacterial membrane |
| title_sort | synthesis of trehalose based chemical tools for the study of the mycobacterial membrane |
| topic | Chemical reporter Metabolic labeling Bioorthogonal probe Trehalose Mycomembrane Corynebacteriales |
| url | https://comptes-rendus.academie-sciences.fr/chimie/articles/10.5802/crchim.246/ |
| work_keys_str_mv | AT lesuremilie synthesisoftrehalosebasedchemicaltoolsforthestudyofthemycobacterialmembrane AT rollandopaulin synthesisoftrehalosebasedchemicaltoolsforthestudyofthemycobacterialmembrane AT guianvarchdominique synthesisoftrehalosebasedchemicaltoolsforthestudyofthemycobacterialmembrane AT bourdreuxyann synthesisoftrehalosebasedchemicaltoolsforthestudyofthemycobacterialmembrane |