The role of natural products targeting macrophage polarization in sepsis-induced lung injury
Abstract Sepsis-induced acute lung injury (SALI) is characterized by a dysregulated inflammatory and immune response. As a key component of the innate immune system, macrophages play a vital role in SALI, in which a macrophage phenotype imbalance caused by an increase in M1 macrophages or a decrease...
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| Format: | Article |
| Language: | English |
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BMC
2025-02-01
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| Series: | Chinese Medicine |
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| Online Access: | https://doi.org/10.1186/s13020-025-01067-4 |
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| author | Yake Li Sinan Ai Yuan Li Wangyu Ye Rui Li Xiaolong Xu Qingquan Liu |
| author_facet | Yake Li Sinan Ai Yuan Li Wangyu Ye Rui Li Xiaolong Xu Qingquan Liu |
| author_sort | Yake Li |
| collection | DOAJ |
| description | Abstract Sepsis-induced acute lung injury (SALI) is characterized by a dysregulated inflammatory and immune response. As a key component of the innate immune system, macrophages play a vital role in SALI, in which a macrophage phenotype imbalance caused by an increase in M1 macrophages or a decrease in M2 macrophages is common. Despite significant advances in SALI research, effective drug therapies are still lacking. Therefore, the development of new treatments for SALI is urgently needed. An increasing number of studies suggest that natural products (NPs) can alleviate SALI by modulating macrophage polarization through various targets and pathways. This review examines the regulatory mechanisms of macrophage polarization and their involvement in the progression of SALI. It highlights how NPs mitigate macrophage imbalances to alleviate SALI, focusing on key signaling pathways such as PI3K/AKT, TLR4/NF-κB, JAK/STAT, IRF, HIF, NRF2, HMGB1, TREM2, PKM2, and exosome-mediated signaling. NPs influencing macrophage polarization are classified into five groups: terpenoids, polyphenols, alkaloids, flavonoids, and others. This work provides valuable insights into the therapeutic potential of NPs in targeting macrophage polarization to treat SALI. Graphical Abstract |
| format | Article |
| id | doaj-art-3dd95c5f6d3243a5a477466e2a712ee0 |
| institution | Kabale University |
| issn | 1749-8546 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Chinese Medicine |
| spelling | doaj-art-3dd95c5f6d3243a5a477466e2a712ee02025-02-09T12:54:16ZengBMCChinese Medicine1749-85462025-02-0120113010.1186/s13020-025-01067-4The role of natural products targeting macrophage polarization in sepsis-induced lung injuryYake Li0Sinan Ai1Yuan Li2Wangyu Ye3Rui Li4Xiaolong Xu5Qingquan Liu6Beijing Hospital of Traditional Chinese Medicine, Capital Medical UniversityChina-Japan Friendship HospitalHenan University of Chinese MedicineGuang’anmen Hospital, China Academy of Chinese Medical SciencesBeijing Hospital of Traditional Chinese Medicine, Capital Medical UniversityBeijing Hospital of Traditional Chinese Medicine, Capital Medical UniversityBeijing Hospital of Traditional Chinese Medicine, Capital Medical UniversityAbstract Sepsis-induced acute lung injury (SALI) is characterized by a dysregulated inflammatory and immune response. As a key component of the innate immune system, macrophages play a vital role in SALI, in which a macrophage phenotype imbalance caused by an increase in M1 macrophages or a decrease in M2 macrophages is common. Despite significant advances in SALI research, effective drug therapies are still lacking. Therefore, the development of new treatments for SALI is urgently needed. An increasing number of studies suggest that natural products (NPs) can alleviate SALI by modulating macrophage polarization through various targets and pathways. This review examines the regulatory mechanisms of macrophage polarization and their involvement in the progression of SALI. It highlights how NPs mitigate macrophage imbalances to alleviate SALI, focusing on key signaling pathways such as PI3K/AKT, TLR4/NF-κB, JAK/STAT, IRF, HIF, NRF2, HMGB1, TREM2, PKM2, and exosome-mediated signaling. NPs influencing macrophage polarization are classified into five groups: terpenoids, polyphenols, alkaloids, flavonoids, and others. This work provides valuable insights into the therapeutic potential of NPs in targeting macrophage polarization to treat SALI. Graphical Abstracthttps://doi.org/10.1186/s13020-025-01067-4Traditional Chinese herbsNatural productsSepsis-induced acute lung injurySALIMacrophage polarizationM1 |
| spellingShingle | Yake Li Sinan Ai Yuan Li Wangyu Ye Rui Li Xiaolong Xu Qingquan Liu The role of natural products targeting macrophage polarization in sepsis-induced lung injury Chinese Medicine Traditional Chinese herbs Natural products Sepsis-induced acute lung injury SALI Macrophage polarization M1 |
| title | The role of natural products targeting macrophage polarization in sepsis-induced lung injury |
| title_full | The role of natural products targeting macrophage polarization in sepsis-induced lung injury |
| title_fullStr | The role of natural products targeting macrophage polarization in sepsis-induced lung injury |
| title_full_unstemmed | The role of natural products targeting macrophage polarization in sepsis-induced lung injury |
| title_short | The role of natural products targeting macrophage polarization in sepsis-induced lung injury |
| title_sort | role of natural products targeting macrophage polarization in sepsis induced lung injury |
| topic | Traditional Chinese herbs Natural products Sepsis-induced acute lung injury SALI Macrophage polarization M1 |
| url | https://doi.org/10.1186/s13020-025-01067-4 |
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