Principles of management of patient with asymptomatic elevation of serum aminotransferases
The aim of publication. Absence of clear practical guidelines on management of patients with asymptomatic elevation of serum aminotransferases can cause difficulties for general practitioners. Presented clinical case illustrates management approach in such cases.The basic contents. Patient D. has ad...
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Gastro LLC
2011-02-01
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| Series: | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
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| Online Access: | https://www.gastro-j.ru/jour/article/view/1375 |
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| author | Ye. N. German M. V. Mayevskaya Ye. O. Lyusina V. T. Ivashkin |
| author_facet | Ye. N. German M. V. Mayevskaya Ye. O. Lyusina V. T. Ivashkin |
| author_sort | Ye. N. German |
| collection | DOAJ |
| description | The aim of publication. Absence of clear practical guidelines on management of patients with asymptomatic elevation of serum aminotransferases can cause difficulties for general practitioners. Presented clinical case illustrates management approach in such cases.The basic contents. Patient D. has admitted to the clinic in July, 2010 for changes blood biochemistry at absence of any symptoms or clinical signs. According to past history it was known: the patient is non-smoker, absolutely denies use of pharmaceuticals and alcohol abuse. At physical examination excessive body weight (BMI of 31 kg/m2) drew attention. The aim of investigation was definition of the cause of elevation of serum aminotransferases activity, and assessment of approach to further management. According to the data of carried out investigation the non-alcoholic steatohepatitis has been diagnosed, that was successfully treated by combination of metformin and ursodeoxycholic acid.Conclusion. Estimating the submitted clinical case it is possible to conclude, that there is no strict association between accumulation of subcutaneous fat and severity of liver steatosis. Hence, non-alcoholic steatohepatitis always should be included in differential diagnostic range of search in patients with asymptomatic elevation of serum aminotransferases. For treatment of nonalcoholic steatohepatitis it is rational to use as drugs of choice metformin (treatment of insulin resistance) and ursodeoxycholic acid (anti-oxidative properties). |
| format | Article |
| id | doaj-art-3de791ccbdb546e09cbf15c1604f003a |
| institution | Kabale University |
| issn | 1382-4376 2658-6673 |
| language | Russian |
| publishDate | 2011-02-01 |
| publisher | Gastro LLC |
| record_format | Article |
| series | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
| spelling | doaj-art-3de791ccbdb546e09cbf15c1604f003a2025-02-10T16:14:31ZrusGastro LLCРоссийский журнал гастроэнтерологии, гепатологии, колопроктологии1382-43762658-66732011-02-012116368930Principles of management of patient with asymptomatic elevation of serum aminotransferasesYe. N. German0M. V. Mayevskaya1Ye. O. Lyusina2V. T. Ivashkin3ГОУ ВПО«1-й Московский государственный медицинский университет им. И.М. Сеченова Росздрава»ГОУ ВПО«1-й Московский государственный медицинский университет им. И.М. Сеченова Росздрава»ГОУ ВПО«1-й Московский государственный медицинский университет им. И.М. Сеченова Росздрава»ГОУ ВПО«1-й Московский государственный медицинский университет им. И.М. Сеченова Росздрава»The aim of publication. Absence of clear practical guidelines on management of patients with asymptomatic elevation of serum aminotransferases can cause difficulties for general practitioners. Presented clinical case illustrates management approach in such cases.The basic contents. Patient D. has admitted to the clinic in July, 2010 for changes blood biochemistry at absence of any symptoms or clinical signs. According to past history it was known: the patient is non-smoker, absolutely denies use of pharmaceuticals and alcohol abuse. At physical examination excessive body weight (BMI of 31 kg/m2) drew attention. The aim of investigation was definition of the cause of elevation of serum aminotransferases activity, and assessment of approach to further management. According to the data of carried out investigation the non-alcoholic steatohepatitis has been diagnosed, that was successfully treated by combination of metformin and ursodeoxycholic acid.Conclusion. Estimating the submitted clinical case it is possible to conclude, that there is no strict association between accumulation of subcutaneous fat and severity of liver steatosis. Hence, non-alcoholic steatohepatitis always should be included in differential diagnostic range of search in patients with asymptomatic elevation of serum aminotransferases. For treatment of nonalcoholic steatohepatitis it is rational to use as drugs of choice metformin (treatment of insulin resistance) and ursodeoxycholic acid (anti-oxidative properties).https://www.gastro-j.ru/jour/article/view/1375serum aminotransferasesasymptomatic courseinvestigation plannon-alcoholic steatohepatitis |
| spellingShingle | Ye. N. German M. V. Mayevskaya Ye. O. Lyusina V. T. Ivashkin Principles of management of patient with asymptomatic elevation of serum aminotransferases Российский журнал гастроэнтерологии, гепатологии, колопроктологии serum aminotransferases asymptomatic course investigation plan non-alcoholic steatohepatitis |
| title | Principles of management of patient with asymptomatic elevation of serum aminotransferases |
| title_full | Principles of management of patient with asymptomatic elevation of serum aminotransferases |
| title_fullStr | Principles of management of patient with asymptomatic elevation of serum aminotransferases |
| title_full_unstemmed | Principles of management of patient with asymptomatic elevation of serum aminotransferases |
| title_short | Principles of management of patient with asymptomatic elevation of serum aminotransferases |
| title_sort | principles of management of patient with asymptomatic elevation of serum aminotransferases |
| topic | serum aminotransferases asymptomatic course investigation plan non-alcoholic steatohepatitis |
| url | https://www.gastro-j.ru/jour/article/view/1375 |
| work_keys_str_mv | AT yengerman principlesofmanagementofpatientwithasymptomaticelevationofserumaminotransferases AT mvmayevskaya principlesofmanagementofpatientwithasymptomaticelevationofserumaminotransferases AT yeolyusina principlesofmanagementofpatientwithasymptomaticelevationofserumaminotransferases AT vtivashkin principlesofmanagementofpatientwithasymptomaticelevationofserumaminotransferases |