Maternal environmental enrichment affects the corpora lutea and progesterone levels in pregnant mice
IntroductionMaternal lifestyle impacts reproductive performance. Previously, we demonstrated that maternal environmental enrichment promotes pregnancy success in BALB/c mice. As progesterone regulates gestation, we decided to study the effect of maternal environmental enrichment on ovarian physiolog...
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2025.1483893/full |
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| author | Fernanda Luz De la Cruz Borthiry Jimena Soledad Beltrame Julieta Aylen Schander Aime Florencia Silva Fernanda Parborell Ana María Franchi María Laura Ribeiro |
| author_facet | Fernanda Luz De la Cruz Borthiry Jimena Soledad Beltrame Julieta Aylen Schander Aime Florencia Silva Fernanda Parborell Ana María Franchi María Laura Ribeiro |
| author_sort | Fernanda Luz De la Cruz Borthiry |
| collection | DOAJ |
| description | IntroductionMaternal lifestyle impacts reproductive performance. Previously, we demonstrated that maternal environmental enrichment promotes pregnancy success in BALB/c mice. As progesterone regulates gestation, we decided to study the effect of maternal environmental enrichment on ovarian physiology during early gestation.MethodsFor this, six-week-old female mice were housed in enriched or control cages for six weeks and then mated with control fertile males. Females with a mucus plug were returned to their respective control or enriched cages. Pregnant mice were euthanized on day 7 of pregnancy, and ovaries and progesterone levels were investigated.ResultsHematoxylin and eosin slices showed no differences in the area (μm2) of the ovaries between control and enriched females. Also, the number of primordial, primary, preantral, antral, and atretic follicles was similar for both treatments. However, the number and area (μm2) of corpora lutea were increased in the ovaries from the enriched group. Moreover, enriched females presented higher progesterone serum levels and increased 3β-HSD expression.DiscussionTherefore, maternal environmental enrichment regulates ovarian physiology, and this could promote the benefits previously reported. |
| format | Article |
| id | doaj-art-3e3ca0cd2e0744c391c15e1417b00673 |
| institution | Kabale University |
| issn | 1664-2392 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj-art-3e3ca0cd2e0744c391c15e1417b006732025-02-10T05:16:06ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922025-02-011610.3389/fendo.2025.14838931483893Maternal environmental enrichment affects the corpora lutea and progesterone levels in pregnant miceFernanda Luz De la Cruz Borthiry0Jimena Soledad Beltrame1Julieta Aylen Schander2Aime Florencia Silva3Fernanda Parborell4Ana María Franchi5María Laura Ribeiro6Laboratorio de Fisiología y Farmacología de la Reproducción, Centro de Estudios Farmacológicos y Botánicos, Universidad de Buenos Aires (UBA)-Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Ciudad Autónoma de Buenos Aires, ArgentinaLaboratorio de Fisiología y Farmacología de la Reproducción, Centro de Estudios Farmacológicos y Botánicos, Universidad de Buenos Aires (UBA)-Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Ciudad Autónoma de Buenos Aires, ArgentinaLaboratorio de Fisiopatología de la Preñez y el Parto, Centro de Estudios Farmacológicos y Botánicos, Universidad de Buenos Aires (UBA)-Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Ciudad Autónoma de Buenos Aires, ArgentinaLaboratorio de Fisiopatología Ovárica, Centro de Estudios Farmacológicos y Botánicos, Universidad de Buenos Aires (UBA)-Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Ciudad Autónoma de Buenos Aires, ArgentinaLaboratorio de Estudios de la Fisiopatología del Ovario, Instituto de Biología y Medicina Experimental, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET)-Fundación Instituto de Biología y Medicina Experimental (IBYME), Ciudad Autónoma de Buenos Aires, ArgentinaLaboratorio de Fisiopatología de la Preñez y el Parto, Centro de Estudios Farmacológicos y Botánicos, Universidad de Buenos Aires (UBA)-Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Ciudad Autónoma de Buenos Aires, ArgentinaLaboratorio de Fisiología y Farmacología de la Reproducción, Centro de Estudios Farmacológicos y Botánicos, Universidad de Buenos Aires (UBA)-Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Ciudad Autónoma de Buenos Aires, ArgentinaIntroductionMaternal lifestyle impacts reproductive performance. Previously, we demonstrated that maternal environmental enrichment promotes pregnancy success in BALB/c mice. As progesterone regulates gestation, we decided to study the effect of maternal environmental enrichment on ovarian physiology during early gestation.MethodsFor this, six-week-old female mice were housed in enriched or control cages for six weeks and then mated with control fertile males. Females with a mucus plug were returned to their respective control or enriched cages. Pregnant mice were euthanized on day 7 of pregnancy, and ovaries and progesterone levels were investigated.ResultsHematoxylin and eosin slices showed no differences in the area (μm2) of the ovaries between control and enriched females. Also, the number of primordial, primary, preantral, antral, and atretic follicles was similar for both treatments. However, the number and area (μm2) of corpora lutea were increased in the ovaries from the enriched group. Moreover, enriched females presented higher progesterone serum levels and increased 3β-HSD expression.DiscussionTherefore, maternal environmental enrichment regulates ovarian physiology, and this could promote the benefits previously reported.https://www.frontiersin.org/articles/10.3389/fendo.2025.1483893/fullmaternal enriched environmentgestationovaryprogesteronecorpora lutea |
| spellingShingle | Fernanda Luz De la Cruz Borthiry Jimena Soledad Beltrame Julieta Aylen Schander Aime Florencia Silva Fernanda Parborell Ana María Franchi María Laura Ribeiro Maternal environmental enrichment affects the corpora lutea and progesterone levels in pregnant mice Frontiers in Endocrinology maternal enriched environment gestation ovary progesterone corpora lutea |
| title | Maternal environmental enrichment affects the corpora lutea and progesterone levels in pregnant mice |
| title_full | Maternal environmental enrichment affects the corpora lutea and progesterone levels in pregnant mice |
| title_fullStr | Maternal environmental enrichment affects the corpora lutea and progesterone levels in pregnant mice |
| title_full_unstemmed | Maternal environmental enrichment affects the corpora lutea and progesterone levels in pregnant mice |
| title_short | Maternal environmental enrichment affects the corpora lutea and progesterone levels in pregnant mice |
| title_sort | maternal environmental enrichment affects the corpora lutea and progesterone levels in pregnant mice |
| topic | maternal enriched environment gestation ovary progesterone corpora lutea |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2025.1483893/full |
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