Advanced sensing strategies for detecting zinc levels and zinc-related biomarkers in cancer pathogenesis
Zinc and zinc-containing proteins are highlighted for their significant contributions to various physiological functions, with abnormal levels of these elements being associated with a wide range of diseases, including cancer, despite zinc itself not being considered a biomarker. Combining the detec...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-02-01
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| Series: | Sensing and Bio-Sensing Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214180425000200 |
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| author | Daniela Vieira Graziele Cruzado Edward Harvey Geraldine Merle |
| author_facet | Daniela Vieira Graziele Cruzado Edward Harvey Geraldine Merle |
| author_sort | Daniela Vieira |
| collection | DOAJ |
| description | Zinc and zinc-containing proteins are highlighted for their significant contributions to various physiological functions, with abnormal levels of these elements being associated with a wide range of diseases, including cancer, despite zinc itself not being considered a biomarker. Combining the detection of zinc and zinc-related biomarkers is an avenue to reliable and cost-effective monitoring. In this context, electrochemical sensing methods offer considerable advantages due to their rapid, simple, and cost-effective detection compared to standard methods. Recent advancements in electrochemical sensors have enhanced sensitivity for detecting low concentrations of zinc-related biomarkers present in early-stage cancer. Furthermore, incorporating carbon, gold, and bismuth nanostructures into sensor recognition elements enhances the capability for rapid, precise, and specific quantification of these biomarkers. This review discusses key zinc-related biomarkers, zinc levels and their roles in cancer development and progression, along with a comprehensive analysis of recent strategies to enhance the sensitivity and specificity of electrochemical sensors for zinc and zinc-related biomarkers. |
| format | Article |
| id | doaj-art-3ed67ed87a8a4fe2b9fd961436478fb8 |
| institution | Kabale University |
| issn | 2214-1804 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Sensing and Bio-Sensing Research |
| spelling | doaj-art-3ed67ed87a8a4fe2b9fd961436478fb82025-02-07T04:47:32ZengElsevierSensing and Bio-Sensing Research2214-18042025-02-0147100754Advanced sensing strategies for detecting zinc levels and zinc-related biomarkers in cancer pathogenesisDaniela Vieira0Graziele Cruzado1Edward Harvey2Geraldine Merle3McGill University, Faculty of Medicine, Department of Experimental Surgery, CanadaPolytechnique Montreal, Department of Chemical Engineering, CanadaMcGill University, Faculty of Medicine, Department of Experimental Surgery, Canada; Department of Surgery, McGill University, Montreal, CanadaMcGill University, Faculty of Medicine, Department of Experimental Surgery, Canada; Polytechnique Montreal, Department of Chemical Engineering, Canada; Corresponding author at: McGill University, Faculty of Medicine, Department of Experimental Surgery, Canada.Zinc and zinc-containing proteins are highlighted for their significant contributions to various physiological functions, with abnormal levels of these elements being associated with a wide range of diseases, including cancer, despite zinc itself not being considered a biomarker. Combining the detection of zinc and zinc-related biomarkers is an avenue to reliable and cost-effective monitoring. In this context, electrochemical sensing methods offer considerable advantages due to their rapid, simple, and cost-effective detection compared to standard methods. Recent advancements in electrochemical sensors have enhanced sensitivity for detecting low concentrations of zinc-related biomarkers present in early-stage cancer. Furthermore, incorporating carbon, gold, and bismuth nanostructures into sensor recognition elements enhances the capability for rapid, precise, and specific quantification of these biomarkers. This review discusses key zinc-related biomarkers, zinc levels and their roles in cancer development and progression, along with a comprehensive analysis of recent strategies to enhance the sensitivity and specificity of electrochemical sensors for zinc and zinc-related biomarkers.http://www.sciencedirect.com/science/article/pii/S2214180425000200ZincZinc-containing proteinsElectrochemical detectionNanostructuresBiosensorsCancer |
| spellingShingle | Daniela Vieira Graziele Cruzado Edward Harvey Geraldine Merle Advanced sensing strategies for detecting zinc levels and zinc-related biomarkers in cancer pathogenesis Sensing and Bio-Sensing Research Zinc Zinc-containing proteins Electrochemical detection Nanostructures Biosensors Cancer |
| title | Advanced sensing strategies for detecting zinc levels and zinc-related biomarkers in cancer pathogenesis |
| title_full | Advanced sensing strategies for detecting zinc levels and zinc-related biomarkers in cancer pathogenesis |
| title_fullStr | Advanced sensing strategies for detecting zinc levels and zinc-related biomarkers in cancer pathogenesis |
| title_full_unstemmed | Advanced sensing strategies for detecting zinc levels and zinc-related biomarkers in cancer pathogenesis |
| title_short | Advanced sensing strategies for detecting zinc levels and zinc-related biomarkers in cancer pathogenesis |
| title_sort | advanced sensing strategies for detecting zinc levels and zinc related biomarkers in cancer pathogenesis |
| topic | Zinc Zinc-containing proteins Electrochemical detection Nanostructures Biosensors Cancer |
| url | http://www.sciencedirect.com/science/article/pii/S2214180425000200 |
| work_keys_str_mv | AT danielavieira advancedsensingstrategiesfordetectingzinclevelsandzincrelatedbiomarkersincancerpathogenesis AT grazielecruzado advancedsensingstrategiesfordetectingzinclevelsandzincrelatedbiomarkersincancerpathogenesis AT edwardharvey advancedsensingstrategiesfordetectingzinclevelsandzincrelatedbiomarkersincancerpathogenesis AT geraldinemerle advancedsensingstrategiesfordetectingzinclevelsandzincrelatedbiomarkersincancerpathogenesis |