Personalised transcranial magnetic stimulation for treatment-resistant depression, depression with comorbid anxiety and negative symptoms of schizophrenia: a narrative review
Transcranial magnetic stimulation (TMS) is a promising intervention for treatment-resistant psychiatric disorders. However, conventional TMS typically utilises a one-size-fits-all approach when determining stimulation targets. Recent retrospective brain circuit-based analyses using lesion network ma...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer – Medknow Publications
2024-10-01
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| Series: | Singapore Medical Journal |
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| Online Access: | https://journals.lww.com/10.4103/singaporemedj.SMJ-2024-133 |
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| _version_ | 1823863754761175040 |
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| author | Xiao Wei Tan Hasvinjit Kaur Gulwant Singh Jovi Zheng Jie Koh Rachel Si Yun Tan Phern Chern Tor |
| author_facet | Xiao Wei Tan Hasvinjit Kaur Gulwant Singh Jovi Zheng Jie Koh Rachel Si Yun Tan Phern Chern Tor |
| author_sort | Xiao Wei Tan |
| collection | DOAJ |
| description | Transcranial magnetic stimulation (TMS) is a promising intervention for treatment-resistant psychiatric disorders. However, conventional TMS typically utilises a one-size-fits-all approach when determining stimulation targets. Recent retrospective brain circuit-based analyses using lesion network mapping have suggested that a left dorsal lateral prefrontal cortex target has a higher efficacy for alleviating depression symptoms, a dorsomedial prefrontal cortex target is more effective for anxiety symptoms, and a rostromedial prefrontal cortex target is effective for schizophrenia-associated psychiatric symptoms. Nonetheless, symptom-specific brain circuit targeting has not been tested prospectively. We conducted a narrative review of selected literature to investigate individualised targeting for TMS and discuss potential future directions to elucidate the efficacy of this approach. |
| format | Article |
| id | doaj-art-403e081303d4486b9b5dcb1225a5ac7a |
| institution | Kabale University |
| issn | 0037-5675 2737-5935 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Wolters Kluwer – Medknow Publications |
| record_format | Article |
| series | Singapore Medical Journal |
| spelling | doaj-art-403e081303d4486b9b5dcb1225a5ac7a2025-02-09T10:25:26ZengWolters Kluwer – Medknow PublicationsSingapore Medical Journal0037-56752737-59352024-10-01651054455110.4103/singaporemedj.SMJ-2024-133Personalised transcranial magnetic stimulation for treatment-resistant depression, depression with comorbid anxiety and negative symptoms of schizophrenia: a narrative reviewXiao Wei TanHasvinjit Kaur Gulwant SinghJovi Zheng Jie KohRachel Si Yun TanPhern Chern TorTranscranial magnetic stimulation (TMS) is a promising intervention for treatment-resistant psychiatric disorders. However, conventional TMS typically utilises a one-size-fits-all approach when determining stimulation targets. Recent retrospective brain circuit-based analyses using lesion network mapping have suggested that a left dorsal lateral prefrontal cortex target has a higher efficacy for alleviating depression symptoms, a dorsomedial prefrontal cortex target is more effective for anxiety symptoms, and a rostromedial prefrontal cortex target is effective for schizophrenia-associated psychiatric symptoms. Nonetheless, symptom-specific brain circuit targeting has not been tested prospectively. We conducted a narrative review of selected literature to investigate individualised targeting for TMS and discuss potential future directions to elucidate the efficacy of this approach.https://journals.lww.com/10.4103/singaporemedj.SMJ-2024-133interventionneurostimulationpersonalised medicinetranscranial magnetic stimulationtreatment-resistant mental illness |
| spellingShingle | Xiao Wei Tan Hasvinjit Kaur Gulwant Singh Jovi Zheng Jie Koh Rachel Si Yun Tan Phern Chern Tor Personalised transcranial magnetic stimulation for treatment-resistant depression, depression with comorbid anxiety and negative symptoms of schizophrenia: a narrative review Singapore Medical Journal intervention neurostimulation personalised medicine transcranial magnetic stimulation treatment-resistant mental illness |
| title | Personalised transcranial magnetic stimulation for treatment-resistant depression, depression with comorbid anxiety and negative symptoms of schizophrenia: a narrative review |
| title_full | Personalised transcranial magnetic stimulation for treatment-resistant depression, depression with comorbid anxiety and negative symptoms of schizophrenia: a narrative review |
| title_fullStr | Personalised transcranial magnetic stimulation for treatment-resistant depression, depression with comorbid anxiety and negative symptoms of schizophrenia: a narrative review |
| title_full_unstemmed | Personalised transcranial magnetic stimulation for treatment-resistant depression, depression with comorbid anxiety and negative symptoms of schizophrenia: a narrative review |
| title_short | Personalised transcranial magnetic stimulation for treatment-resistant depression, depression with comorbid anxiety and negative symptoms of schizophrenia: a narrative review |
| title_sort | personalised transcranial magnetic stimulation for treatment resistant depression depression with comorbid anxiety and negative symptoms of schizophrenia a narrative review |
| topic | intervention neurostimulation personalised medicine transcranial magnetic stimulation treatment-resistant mental illness |
| url | https://journals.lww.com/10.4103/singaporemedj.SMJ-2024-133 |
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