Effects of fine particulate matter and its chemical constituents on influenza-like illness in Guangzhou, China
Background: Although the link between fine particulate matter (PM2.5) and influenza-like illness (ILI) is well established, the effect of the chemical constituents of PM2.5 on ILI remains unclear. This study aims to explore this effect in Guangzhou, China. Methods: Daily data on ILI cases, PM2.5 lev...
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Elsevier
2025-01-01
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| Series: | Ecotoxicology and Environmental Safety |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651324016166 |
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| author | Keyi Wu Weidong Fan Jing Wei Jianyun Lu Xiaowei Ma Zelin Yuan Zhiwei Huang Qi Zhong Yining Huang Fei Zou Xianbo Wu |
| author_facet | Keyi Wu Weidong Fan Jing Wei Jianyun Lu Xiaowei Ma Zelin Yuan Zhiwei Huang Qi Zhong Yining Huang Fei Zou Xianbo Wu |
| author_sort | Keyi Wu |
| collection | DOAJ |
| description | Background: Although the link between fine particulate matter (PM2.5) and influenza-like illness (ILI) is well established, the effect of the chemical constituents of PM2.5 on ILI remains unclear. This study aims to explore this effect in Guangzhou, China. Methods: Daily data on ILI cases, PM2.5 levels, and specific PM2.5 constituents (black carbon [BC], chlorine [Cl−], ammonia [NH4+], nitrate [NO3−], and sulfate [SO42−]) in Guangzhou, China, were collected for the period of 2014–2019. Additionally, data on gaseous pollutants and meteorological conditions were obtained. By using quasi-Poisson regression models, the association between exposure to PM2.5 and its constituents and ILI risk was estimated. Stratified subgroup analyses were performed by gender, age, and season to explore in depth the effects of these factors on disease risk. Results: Single-pollutant modeling results showed that an increase of one interquartile range (IQR) in Cl−, SO42−, PM2.5, NH4+, BC, and NO3− corresponded to relative risks of ILI of 1.046 (95 % CI: 1.004, 1.090) (lag03), 1.098 (95 % CI: 1.058, 1.139) (lag01), 1.091 (95 % CI: 1.054, 1.130) (lag02), 1.093 (95 % CI: 1.049, 1.138) (lag02), 1.111 (95 % CI: 1.074, 1.150) (lag03), and 1.103 (95 % CI: 1.061, 1.146) (lag03), respectively. Notably, the association between ILI and BC remained significant even after adjusting for PM2.5 mass. Subgroup analyses indicated that individuals aged 5–14 and 15–24 years may exhibit higher sensitivity to BC and Cl− exposure than other individuals. Furthermore, stronger associations were observed during the cold season than during the warm season. Conclusions: Results showed that the mass and constituents of PM2.5 were significantly correlated with ILI. Specifically, the carbonaceous fractions of PM2.5 were found to have a pronounced effect on ILI. These findings underscore the importance of implementing effective measures to reduce the emission of specific sources of PM2.5 constituents to mitigate the risk of ILI. Nevertheless, limitations such as potential exposure misclassification and regional constraints should be considered. |
| format | Article |
| id | doaj-art-40d26e10c2534426b324a09b65443e46 |
| institution | Kabale University |
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| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
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| series | Ecotoxicology and Environmental Safety |
| spelling | doaj-art-40d26e10c2534426b324a09b65443e462025-02-12T05:29:35ZengElsevierEcotoxicology and Environmental Safety0147-65132025-01-01290117540Effects of fine particulate matter and its chemical constituents on influenza-like illness in Guangzhou, ChinaKeyi Wu0Weidong Fan1Jing Wei2Jianyun Lu3Xiaowei Ma4Zelin Yuan5Zhiwei Huang6Qi Zhong7Yining Huang8Fei Zou9Xianbo Wu10Department of Epidemiology, School of Public Health, Southern Medical University (Guangdong Provincial Key Laboratory of Tropical Disease Research), No.1023–1063, Shatai South Road, Baiyun District, Guangzhou 510515, ChinaDepartment of Epidemiology, School of Public Health, Southern Medical University (Guangdong Provincial Key Laboratory of Tropical Disease Research), No.1023–1063, Shatai South Road, Baiyun District, Guangzhou 510515, ChinaDepartment of Atmospheric and Oceanic Science, Earth System Science Interdisciplinary Center, University of Maryland, College Park, MD 20740, USAGuangzhou Baiyun Center for Disease Control and Prevention, Guangzhou City, Guangdong 510440, ChinaGuangzhou Center for Disease Control and Prevention, Guangzhou City, Guangdong 510440, ChinaDepartment of Epidemiology, School of Public Health, Southern Medical University (Guangdong Provincial Key Laboratory of Tropical Disease Research), No.1023–1063, Shatai South Road, Baiyun District, Guangzhou 510515, ChinaDepartment of Epidemiology, School of Public Health, Southern Medical University (Guangdong Provincial Key Laboratory of Tropical Disease Research), No.1023–1063, Shatai South Road, Baiyun District, Guangzhou 510515, ChinaDepartment of Epidemiology, School of Public Health, Southern Medical University (Guangdong Provincial Key Laboratory of Tropical Disease Research), No.1023–1063, Shatai South Road, Baiyun District, Guangzhou 510515, ChinaDepartment of Epidemiology, School of Public Health, Southern Medical University (Guangdong Provincial Key Laboratory of Tropical Disease Research), No.1023–1063, Shatai South Road, Baiyun District, Guangzhou 510515, ChinaDepartment of Occupational Health and Medicine, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, No.1023–1063, Shatai South Road, Baiyun District, Guangzhou 510515, China; Corresponding authors.Department of Epidemiology, School of Public Health, Southern Medical University (Guangdong Provincial Key Laboratory of Tropical Disease Research), No.1023–1063, Shatai South Road, Baiyun District, Guangzhou 510515, China; Corresponding authors.Background: Although the link between fine particulate matter (PM2.5) and influenza-like illness (ILI) is well established, the effect of the chemical constituents of PM2.5 on ILI remains unclear. This study aims to explore this effect in Guangzhou, China. Methods: Daily data on ILI cases, PM2.5 levels, and specific PM2.5 constituents (black carbon [BC], chlorine [Cl−], ammonia [NH4+], nitrate [NO3−], and sulfate [SO42−]) in Guangzhou, China, were collected for the period of 2014–2019. Additionally, data on gaseous pollutants and meteorological conditions were obtained. By using quasi-Poisson regression models, the association between exposure to PM2.5 and its constituents and ILI risk was estimated. Stratified subgroup analyses were performed by gender, age, and season to explore in depth the effects of these factors on disease risk. Results: Single-pollutant modeling results showed that an increase of one interquartile range (IQR) in Cl−, SO42−, PM2.5, NH4+, BC, and NO3− corresponded to relative risks of ILI of 1.046 (95 % CI: 1.004, 1.090) (lag03), 1.098 (95 % CI: 1.058, 1.139) (lag01), 1.091 (95 % CI: 1.054, 1.130) (lag02), 1.093 (95 % CI: 1.049, 1.138) (lag02), 1.111 (95 % CI: 1.074, 1.150) (lag03), and 1.103 (95 % CI: 1.061, 1.146) (lag03), respectively. Notably, the association between ILI and BC remained significant even after adjusting for PM2.5 mass. Subgroup analyses indicated that individuals aged 5–14 and 15–24 years may exhibit higher sensitivity to BC and Cl− exposure than other individuals. Furthermore, stronger associations were observed during the cold season than during the warm season. Conclusions: Results showed that the mass and constituents of PM2.5 were significantly correlated with ILI. Specifically, the carbonaceous fractions of PM2.5 were found to have a pronounced effect on ILI. These findings underscore the importance of implementing effective measures to reduce the emission of specific sources of PM2.5 constituents to mitigate the risk of ILI. Nevertheless, limitations such as potential exposure misclassification and regional constraints should be considered.http://www.sciencedirect.com/science/article/pii/S0147651324016166PM2.5 constituentsInfluenza-like illnessAir pollutionShort-term effects |
| spellingShingle | Keyi Wu Weidong Fan Jing Wei Jianyun Lu Xiaowei Ma Zelin Yuan Zhiwei Huang Qi Zhong Yining Huang Fei Zou Xianbo Wu Effects of fine particulate matter and its chemical constituents on influenza-like illness in Guangzhou, China Ecotoxicology and Environmental Safety PM2.5 constituents Influenza-like illness Air pollution Short-term effects |
| title | Effects of fine particulate matter and its chemical constituents on influenza-like illness in Guangzhou, China |
| title_full | Effects of fine particulate matter and its chemical constituents on influenza-like illness in Guangzhou, China |
| title_fullStr | Effects of fine particulate matter and its chemical constituents on influenza-like illness in Guangzhou, China |
| title_full_unstemmed | Effects of fine particulate matter and its chemical constituents on influenza-like illness in Guangzhou, China |
| title_short | Effects of fine particulate matter and its chemical constituents on influenza-like illness in Guangzhou, China |
| title_sort | effects of fine particulate matter and its chemical constituents on influenza like illness in guangzhou china |
| topic | PM2.5 constituents Influenza-like illness Air pollution Short-term effects |
| url | http://www.sciencedirect.com/science/article/pii/S0147651324016166 |
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