Spontaneous splenic rupture associated with Q fever and portal hypertension: A case report
Spontaneous splenic rupture (SSR) is an exceptionally rare and life-threatening condition, with its pathophysiology remaining poorly understood. This report describes the first documented case of SSR in a patient with Q fever infection and underlying liver cirrhosis with portal hypertension. The pat...
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2025.1527701/full |
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| author | Cecil Mustafiz Cecil Mustafiz Deloshaan Subhaharan Deloshaan Subhaharan Daniel Chorley Tariq Masood |
| author_facet | Cecil Mustafiz Cecil Mustafiz Deloshaan Subhaharan Deloshaan Subhaharan Daniel Chorley Tariq Masood |
| author_sort | Cecil Mustafiz |
| collection | DOAJ |
| description | Spontaneous splenic rupture (SSR) is an exceptionally rare and life-threatening condition, with its pathophysiology remaining poorly understood. This report describes the first documented case of SSR in a patient with Q fever infection and underlying liver cirrhosis with portal hypertension. The patient was a man in his late 30 s who presented with severe abdominal pain, vomiting and hypovolemic shock who required emergency splenectomy due to unstable splenic hemorrhage. Post-operatively, a diagnosis of Q fever was confirmed through serological testing. To date, there has only been six cases describing splenic rupture precipitated by Q fever, and none in the context of concurrent portal hypertension. Conversely, portal hypertension is an independent risk factor for splenic complications including splenomegaly and hypersplenism. This case underlines the critical need to consider rare etiologies, offers valuable insights into the pathogenesis of SSR, and emphasizes the importance of early recognition and multidisciplinary management. Moreover, a proposed algorithm for the diagnosis and management of SSR has been included for clinicians who face similar complex presentations. |
| format | Article |
| id | doaj-art-40e5d42ba106490484956d7f113a23e8 |
| institution | Kabale University |
| issn | 2296-858X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj-art-40e5d42ba106490484956d7f113a23e82025-02-11T06:59:27ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2025-02-011210.3389/fmed.2025.15277011527701Spontaneous splenic rupture associated with Q fever and portal hypertension: A case reportCecil Mustafiz0Cecil Mustafiz1Deloshaan Subhaharan2Deloshaan Subhaharan3Daniel Chorley4Tariq Masood5Department of Digestive Health, Gold Coast University Hospital, Gold Coast, QLD, AustraliaSchool of Medicine and Dentistry, Griffith University, Gold Coast, QLD, AustraliaDepartment of Digestive Health, Gold Coast University Hospital, Gold Coast, QLD, AustraliaSchool of Medicine and Dentistry, Griffith University, Gold Coast, QLD, AustraliaDepartment of Digestive Health, Gold Coast University Hospital, Gold Coast, QLD, AustraliaDepartment of Digestive Health, Gold Coast University Hospital, Gold Coast, QLD, AustraliaSpontaneous splenic rupture (SSR) is an exceptionally rare and life-threatening condition, with its pathophysiology remaining poorly understood. This report describes the first documented case of SSR in a patient with Q fever infection and underlying liver cirrhosis with portal hypertension. The patient was a man in his late 30 s who presented with severe abdominal pain, vomiting and hypovolemic shock who required emergency splenectomy due to unstable splenic hemorrhage. Post-operatively, a diagnosis of Q fever was confirmed through serological testing. To date, there has only been six cases describing splenic rupture precipitated by Q fever, and none in the context of concurrent portal hypertension. Conversely, portal hypertension is an independent risk factor for splenic complications including splenomegaly and hypersplenism. This case underlines the critical need to consider rare etiologies, offers valuable insights into the pathogenesis of SSR, and emphasizes the importance of early recognition and multidisciplinary management. Moreover, a proposed algorithm for the diagnosis and management of SSR has been included for clinicians who face similar complex presentations.https://www.frontiersin.org/articles/10.3389/fmed.2025.1527701/fullsplenic ruptureportal hypertensioncirrhosisQ feverhepatitis Chepatology |
| spellingShingle | Cecil Mustafiz Cecil Mustafiz Deloshaan Subhaharan Deloshaan Subhaharan Daniel Chorley Tariq Masood Spontaneous splenic rupture associated with Q fever and portal hypertension: A case report Frontiers in Medicine splenic rupture portal hypertension cirrhosis Q fever hepatitis C hepatology |
| title | Spontaneous splenic rupture associated with Q fever and portal hypertension: A case report |
| title_full | Spontaneous splenic rupture associated with Q fever and portal hypertension: A case report |
| title_fullStr | Spontaneous splenic rupture associated with Q fever and portal hypertension: A case report |
| title_full_unstemmed | Spontaneous splenic rupture associated with Q fever and portal hypertension: A case report |
| title_short | Spontaneous splenic rupture associated with Q fever and portal hypertension: A case report |
| title_sort | spontaneous splenic rupture associated with q fever and portal hypertension a case report |
| topic | splenic rupture portal hypertension cirrhosis Q fever hepatitis C hepatology |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2025.1527701/full |
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