Vitamin D deficiency and intracranial aneurysms: Systematic Review
Background: Low vitamin D levels have been associated with an increased risk in patients with cerebrovascular diseases. However, solid evidence linking intracranial aneurysm (IA) to hypovitaminosis D is still lacking. This review aims to evaluate if there is a relationship between vitamin D deficien...
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Elsevier
2025-01-01
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| Series: | World Neurosurgery: X |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590139724001443 |
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| author | Lívio Pereira de Macêdo Glaudir Donato Maria Eduarda d’Almeida Lins Regis Isabela Fernandes de Melo Pereira Gustavo Rodrigues Paulo Kamilla Azevedo Bringel Gabriel Carvalho Andrade Gadelha Fábio Antônio Serra de Lima Júnior Yally Dayanne Oliveira Ferreira Renata de Castro Tavares Arlindo Ugulino Netto Kauê Franke Pierre Vansant Oliveira Eugênio Auricélio Batista Cezar-Junior Igor Vilela Faquini Eduardo Vieira de Carvalho Júnior Nivaldo Sena de Almeida Francisco Alfredo Bandeira e Farias Marcelo Moraes Valença Hildo Rocha Cirne Azevedo-Filho |
| author_facet | Lívio Pereira de Macêdo Glaudir Donato Maria Eduarda d’Almeida Lins Regis Isabela Fernandes de Melo Pereira Gustavo Rodrigues Paulo Kamilla Azevedo Bringel Gabriel Carvalho Andrade Gadelha Fábio Antônio Serra de Lima Júnior Yally Dayanne Oliveira Ferreira Renata de Castro Tavares Arlindo Ugulino Netto Kauê Franke Pierre Vansant Oliveira Eugênio Auricélio Batista Cezar-Junior Igor Vilela Faquini Eduardo Vieira de Carvalho Júnior Nivaldo Sena de Almeida Francisco Alfredo Bandeira e Farias Marcelo Moraes Valença Hildo Rocha Cirne Azevedo-Filho |
| author_sort | Lívio Pereira de Macêdo |
| collection | DOAJ |
| description | Background: Low vitamin D levels have been associated with an increased risk in patients with cerebrovascular diseases. However, solid evidence linking intracranial aneurysm (IA) to hypovitaminosis D is still lacking. This review aims to evaluate if there is a relationship between vitamin D deficiency and the incidence and rupture of IA. Methods: A systematic search of papers was performed in the following databases: MEDLINE, EMBASE, LILACS, and Web of Science. The selected papers covered data on vitamin D levels and the occurrence or rupture of IA and/or other complications of this condition. The risk of bias analysis was performed with tools developed by the National Heart, Lung, and Blood Institute. Tables were developed to synthesize the qualitative analysis of the data. Results: Six studies from five different countries were included covering a total of 14,184 participants. A relationship between low vitamin D levels and IA incidence was detected in all studies. In terms of rupture and complications, there was a tendency of association with hypovitaminosis. Discussion: Among the limitations of the papers, the following are noteworthy: sample size and selection, recording flaws inherent to retrospective designs, failure to consider confounding variables, and heterogeneity of data produced among the researches, making a quantitative analysis of the evidence unfeasible. From the results obtained, we can identify a higher incidence of hypovitaminosis D in patients with IA. Yet, further studies need to be conducted in investigating the relationships between low vitamin D levels and rupture or other complications (CRD42022363369). |
| format | Article |
| id | doaj-art-415bf0e81ec44bd289ce1ce403add5a9 |
| institution | Kabale University |
| issn | 2590-1397 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
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| series | World Neurosurgery: X |
| spelling | doaj-art-415bf0e81ec44bd289ce1ce403add5a92025-02-10T04:34:50ZengElsevierWorld Neurosurgery: X2590-13972025-01-0125100413Vitamin D deficiency and intracranial aneurysms: Systematic ReviewLívio Pereira de Macêdo0Glaudir Donato1Maria Eduarda d’Almeida Lins Regis2Isabela Fernandes de Melo Pereira3Gustavo Rodrigues Paulo4Kamilla Azevedo Bringel5Gabriel Carvalho Andrade Gadelha6Fábio Antônio Serra de Lima Júnior7Yally Dayanne Oliveira Ferreira8Renata de Castro Tavares9Arlindo Ugulino Netto10Kauê Franke11Pierre Vansant Oliveira Eugênio12Auricélio Batista Cezar-Junior13Igor Vilela Faquini14Eduardo Vieira de Carvalho Júnior15Nivaldo Sena de Almeida16Francisco Alfredo Bandeira e Farias17Marcelo Moraes Valença18Hildo Rocha Cirne Azevedo-Filho19Department of Neurosurgery, Hospital da Restauração, Recife, Pernambuco, Brazil; Universidade Federal de Pernambuco, Recife, Pernambuco, Brazil; Corresponding author. Rua Nogueira de Souza, 326, Pina, Recife, PE, 51110-110 , Brazil.Centro de Ciências Médicas, Universidade Federal da Paraíba, Joã Pessoa, Paraíba, BrazilCentro de Ciências Médicas, Universidade Federal da Paraíba, Joã Pessoa, Paraíba, BrazilFaculdade de Ciências Médicas da Paraíba, João Pessoa, Paraíba, BrazilUniversidade Federal de Campina Grande, Campina Grande, Paraíba, BrazilCentro de Ciências Médicas, Universidade Federal da Paraíba, Joã Pessoa, Paraíba, BrazilCentro de Ciências Médicas, Universidade Federal da Paraíba, Joã Pessoa, Paraíba, BrazilCentro de Ciências Médicas, Universidade Federal da Paraíba, Joã Pessoa, Paraíba, BrazilHospital Agamenon Magalhães, Recife, PE, BrazilHospital Agamenon Magalhães, Recife, PE, BrazilDepartment of Neurosurgery, Hospital da Restauração, Recife, Pernambuco, BrazilDepartment of Neurosurgery, Hospital da Restauração, Recife, Pernambuco, BrazilDepartment of Neurosurgery, Hospital da Restauração, Recife, Pernambuco, BrazilDepartment of Neurosurgery, Hospital da Restauração, Recife, Pernambuco, BrazilDepartment of Neurosurgery, Hospital da Restauração, Recife, Pernambuco, BrazilDepartment of Neurosurgery, Hospital da Restauração, Recife, Pernambuco, BrazilDepartment of Neurosurgery, Hospital da Restauração, Recife, Pernambuco, BrazilHospital Agamenon Magalhães, Recife, PE, BrazilUniversidade Federal de Pernambuco, Recife, Pernambuco, BrazilDepartment of Neurosurgery, Hospital da Restauração, Recife, Pernambuco, Brazil; Universidade Federal de Pernambuco, Recife, Pernambuco, BrazilBackground: Low vitamin D levels have been associated with an increased risk in patients with cerebrovascular diseases. However, solid evidence linking intracranial aneurysm (IA) to hypovitaminosis D is still lacking. This review aims to evaluate if there is a relationship between vitamin D deficiency and the incidence and rupture of IA. Methods: A systematic search of papers was performed in the following databases: MEDLINE, EMBASE, LILACS, and Web of Science. The selected papers covered data on vitamin D levels and the occurrence or rupture of IA and/or other complications of this condition. The risk of bias analysis was performed with tools developed by the National Heart, Lung, and Blood Institute. Tables were developed to synthesize the qualitative analysis of the data. Results: Six studies from five different countries were included covering a total of 14,184 participants. A relationship between low vitamin D levels and IA incidence was detected in all studies. In terms of rupture and complications, there was a tendency of association with hypovitaminosis. Discussion: Among the limitations of the papers, the following are noteworthy: sample size and selection, recording flaws inherent to retrospective designs, failure to consider confounding variables, and heterogeneity of data produced among the researches, making a quantitative analysis of the evidence unfeasible. From the results obtained, we can identify a higher incidence of hypovitaminosis D in patients with IA. Yet, further studies need to be conducted in investigating the relationships between low vitamin D levels and rupture or other complications (CRD42022363369).http://www.sciencedirect.com/science/article/pii/S2590139724001443Vitamin DIntracranial aneurysmsSubarachnoid hemorrhage |
| spellingShingle | Lívio Pereira de Macêdo Glaudir Donato Maria Eduarda d’Almeida Lins Regis Isabela Fernandes de Melo Pereira Gustavo Rodrigues Paulo Kamilla Azevedo Bringel Gabriel Carvalho Andrade Gadelha Fábio Antônio Serra de Lima Júnior Yally Dayanne Oliveira Ferreira Renata de Castro Tavares Arlindo Ugulino Netto Kauê Franke Pierre Vansant Oliveira Eugênio Auricélio Batista Cezar-Junior Igor Vilela Faquini Eduardo Vieira de Carvalho Júnior Nivaldo Sena de Almeida Francisco Alfredo Bandeira e Farias Marcelo Moraes Valença Hildo Rocha Cirne Azevedo-Filho Vitamin D deficiency and intracranial aneurysms: Systematic Review World Neurosurgery: X Vitamin D Intracranial aneurysms Subarachnoid hemorrhage |
| title | Vitamin D deficiency and intracranial aneurysms: Systematic Review |
| title_full | Vitamin D deficiency and intracranial aneurysms: Systematic Review |
| title_fullStr | Vitamin D deficiency and intracranial aneurysms: Systematic Review |
| title_full_unstemmed | Vitamin D deficiency and intracranial aneurysms: Systematic Review |
| title_short | Vitamin D deficiency and intracranial aneurysms: Systematic Review |
| title_sort | vitamin d deficiency and intracranial aneurysms systematic review |
| topic | Vitamin D Intracranial aneurysms Subarachnoid hemorrhage |
| url | http://www.sciencedirect.com/science/article/pii/S2590139724001443 |
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